General Information
Revision date
2000-02-01
Product name
Doxorubicin hydrochloride
Product Synonyms
Hydroxydaunorubicin hydrochloride; Adriamycin hydrochloride; cytotoxic drug; immunosuppressive agent; anthracycline
CAS No.
25316-40-9
Icons in SDS
Company Information
company name
Fisher Scientific
GHS Information
Signal word
Warning!
Section 2
SECTION 2: Hazards identification
EMERGENCY OVERVIEW Appearance: reddish powder. Warning! Suspect cancer hazard. May cause cancer. Causes severe eye and skin irritation. May cause allergic skin reaction. May be harmful if swallowed, inhaled, or absorbed through the skin. Causes severe respiratory tract irritation. Possible risk of harm to the unborn child. Possible risk of impaired fertility. Target Organs: Blood, kidneys, heart, respiratory system, eyes, bone marrow, immune system, skin, nerves.
Potential health effects
Eye: Causes severe eye irritation. Skin: Causes skin irritation. This material is a vesicant, that is, it will induce blistering. May cause an allergic reaction in certain individuals. Ingestion: May cause gastrointestinal irritation with nausea, vomiting and diarrhea. Human fatalities have been reported from acute poisoning. Inhalation: Causes respiratory tract irritation. Can produce delayed pulmonary edema. Chronic: Prolonged or repeated exposure may cause adverse reproductive effects. Cancer suspect agent. Prolonged and/or repeated skin exposure may cause allergic dermatitis. Intermittent intravenous injections in man of 12 mg/kg over 26 week period caused cardiomyopathy including infarction and acute pulmonary edema. Intravenous injections in man have also caused acute renal failure.
