Cyclohexanone

SECTION 2: Hazards identification

EMERGENCY OVERVIEW Appearance clear, colorless to pale yellow liquid. Flash Point 44 deg C Warning! Harmful if absorbed through the skin. May cause severe eye irritation and possible injury. Flammable liquid and vapor. Harmful if inhaled. Causes skin and respiratory tract irritation. May be harmful if swallowed. May cause central nervous system depression. May cause liver and kidney damage. Target Organs: Kidneys, central nervous system, liver, respiratory system, eyes, skin.

Potential health effects

Eye: May result in corneal injury. Vapors may cause eye irritation. Contact produces irritation, tearing, and burning pain. Undiluted cyclohexanone placed in the eyes of rabbits caused marked irritation and some corneal injury. Skin: Causes skin irritation. Harmful if absorbed through the skin. Not expected to cause an allergic skin reaction. Cyclohexanone was not a sensitizer in the guinea pig maximization test and the mouse ear swelling test. There has been one case report of sensitization to cyclohexanone itself in a patient using a PVC adhesive composed of 100% cyclohexanone; patch testing confirmed the sensitization. Ingestion: Causes gastrointestinal irritation with nausea, vomiting and diarrhea. May cause liver and kidney damage. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure. May be harmful if swallowed. Inhalation: Causes respiratory tract irritation. May cause liver and kidney damage. Inhalation overexposure may lead to central nervous system depression, producing effects such as dizziness, headache, confusion, incoordination, nausea, weakness, and loss of consciousness. Extreme exposures may cause other CNS effects including death. Cyclohexanone has caused damage to the liver and kidneys in rabbits exposed by inhalation to an airborne concentration of 190 ppm. Chronic: Prolonged or repeated skin contact may cause defatting and dermatitis. Prolonged exposure may cause non-specific nervous system effects. Animal studies indicate that the product may affect the liver and kidneys.