Cabozantinib (S)-malate

Hazard statements (CLP)

H373

Code

Statements

H373

May cause damage to organs through prolonged or repeated exposure

SECTION 2: Hazards identification

Classification WHMIS 2015 Classification This product is hazardous in accordance with the Canada Hazardous Products Act (HPA) and Hazardous Products Regulation (HPR), as amended (SOR/2022-272) Acute oral toxicity Category 4 Skin Corrosion/Irritation Category 2 Serious Eye Damage/Eye Irritation Category 2 Reproductive Toxicity Category 1B Specific target organ toxicity (single exposure) Category 3 Target Organs - Respiratory system Specific target organ toxicity - (repeated exposure) Category 2 Label Elements

Signal word

Danger Hazard Statements Harmful if swallowed Causes skin irritation Causes serious eye irritation May cause respiratory irritation May damage fertility. May damage the unborn child May cause damage to organs through prolonged or repeated exposure

Prevention

Obtain special instructions before use Do not handle until all safety precautions have been read and understood Do not breathe dust/fumes/gas/mist/vapours/spray Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product Use only outdoors or in a well-ventilated area Wear protective gloves/protective clothing/eye protection/face protection

Response

IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell IF ON SKIN: Wash with plenty of soap and water IF INHALED: Remove person to fresh air and keep comfortable for breathing IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing IF exposed or concerned: Get medical advice/attention Rinse mouth If skin irritation occurs: Get medical advice/attention Take off contaminated clothing and wash it before reuse

Storage

Store locked up Store in a well-ventilated place. Keep container tightly closed

Disposal

Dispose of contents/container to an approved waste disposal plant

2.1 Classification of the substance or mixture

and Hazardous Products Regulation (HPR), as amended (SOR/2022-272) Acute oral toxicity Category 4 Skin Corrosion/Irritation Category 2 Serious Eye Damage/Eye Irritation Category 2 Reproductive Toxicity Category 1B Specific target organ toxicity (single exposure) Category 3 Target Organs - Respiratory system. Specific target organ toxicity - (repeated exposure) Category 2 Label Elements