PX-866 (Sonolisib)

Hazard statements (CLP)

H302, H312, H315, H319, H332, H335

Code

Statements

H302

Harmful if swallowed

SECTION 2: Hazards identification

US OSHA 1910.1200 Classification of the Substance To our judgement, the hazards of this substance have not been thoroughly investigated

Signal word

Hazard Statements H302 Harmful if swallowed P301+P317, P330 H312 Harmful in contact with skin P302+P352, P317, P321, P362+P364 H332 Harmful if inhaled P304+P340, P317 H315 Causes skin irritation P302+P352, P321, P332+P317, P362+P364 H319 Causes serious eye irritation P305+P351+P338, P337+P317 H335 May cause respiratory irritation P304+P340, P319

Precautionary statements

P203 Obtain, read and follow all safety instructions before use. P261 Avoid breathing dust or mist. P264 Wash {hands} thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P272 Contaminated work clothing should not be allowed out of the workplace. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection

Response

Acute oral P301+P317,P330 (IV) IF SWALLOWED Get medical help. Rinse mouth Acute inhal: P304+P340, (IV) IF INHALED: Remove person to fresh air and keep comfortable for P317 breathing. Get emergency medical help. Acute skin P302+P352, P302+P352 IF ON SKIN wash with plenty of water P317, P317: Get emergency medical help. P362+P364 P362+P364:Take off contaminated clothing and wash it before reuse. Irrit. Skin P302+P352, P302+P352 IF ON SKIN wash with plenty of water P332+P317, P362+P364 P332+P317 If skin irritation occurs Get medical help P362+P364 P362+P364:Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES Rinse cautiously with water for several Eye irrit. P305+P351+P338, minutes. Remove contact lenses if present and easy to do - continue P337+P317 rinsing P337+P317 If eye irritation persists Get medical help Stot/re respirat. H319 P319: Get medical help if you feel unwell.

2.1 Classification of the substance or mixture

To our judgement, the hazards of this substance have not been thoroughly investigated 2.1.1. GHS Classification: According to EU Reg. 1272/2008 and US OSHA 1910.1200) No toxicologicaldata relevant for the classification of PX-866 (Sonolisib). We used the classification fron PUBCHEM instead.. Data source:<RTECS>RTECS. <Fer>Manufacturer’s estimation; <SF>Sci finder;<SDS>other authors;<J>Scient.publication; <PC>PubChem Accute toxicity: Oral Cat.4 H302 Harmful if swallowed Accute toxicity: Dermal Cat.4 H312 Harmful in contact with skin Accute toxicity: Inhalation Cat.4 H332 Harmful if inhaled Skin corrosion/irritation Cat.2 H315 Causes skin irritation Serious eye damage/eye irritation Cat.2A H319 Causes serious eye irritation STOT/SE Respiratory tract irritation Cat.3 H335