Verapamil Hydrochloride Injection, USP

SECTION 2: Hazards identification

OSHA Primary Physical and Health Hazards: This material should be considered potentially irritating to the eyes and respiratory tract. Based on clinical use, possible target organs include the cardiovascular system. Routes of Entry: Inhalation, eye/skin contact, or ingestion. This product is intended for therapeutic use only when prescribed by a physician. Potential adverse reactions from prescribed doses and overdoses are described in the package insert. The following signs and symptoms have occurred in individuals: severe hypotension, cardiogenic shock, second- degree AV block, third-degree AV block, sick sinus syndrome, severe congestive heart failure. Treatment of overdosage should be supportive and individualized. Beta-adrenergic stimulation and/or Signs and Symptoms of Exposure: parenteral administration of calcium injections may increase calcium ion flux across the slow channel, and have been effectively used in treatment of deliberate overdosage with oral verapamil hydrochloride. Verapamil Hydrochloride cannot be removed by hemodialysis. Clinically significant hypotensive reactions or high-degree AV block should be treated with vasopressor agents and/or cardiac pacing. Asystole should be handled by the usual measures including isoproterenol hydrochloride, other vasopressor agents, or cardiopulmonary resuscitation to treat acute overdosage with Verapamil Hydrochloride Injection. Chemical Listed as Carcinogen

Medical Conditions Generally Aggravated by Exposure

Hypersensitivity to any of the product’s components.