824-1803 CHROMA-CHEM RAW SIENNA

SECTION 2: Hazards identification

EMERGENCY OVERVIEW *** Form-paste Color-brown Odor-Petroleum distillate odor. Combustible liquid and vapor. May cause eye, skin and respiratory tract irritation.

Potential health effects

Eye contact According to test results on similar colorant base mixtures, this product is classified as a moderate eye irritant. May cause tearing, reddening and/or swelling. Skin Contact Prolonged or repeated contact may result in defatting and drying of the skin causing skin irritation and dermatitis (rash). Moderate irritant according to test results on similar base mixtures. Inhalation Possibly irritating. Excessive inhalation of solvent vapors may cause nasal and respiratory irritation and central nervous system effects including dizziness, weakness, fatigue, nausea, headache, possible unconsciousness and even death. Ingestion May cause gastrointestinal irritation, nausea, vomiting, and diarrhea.

Health hazards

Health studies have shown that many petroleum hydrocarbons pose potential human health risks which may vary from person to person.As a precaution, exposure to liquids, vapours, mists or fumes shoud be minimized. Short term exposures to talc may cause lung irritation. Long term excessive exposure to talc dust may cause talcosis, a pulmonary fibrosis which in turn may lead to severe and permanent damage to the lungs. NTP Toxicology and Carcinogenesis Studies of Talc revealed that there is some evidence of carcinogenic activity in male rats and clear evidence of carcinogenic activity in female rats. There was no evidence of carcinogenic activity in male or female mice. Prolonged inhalation of iron oxide dust is known to produce a condition known as siderosis. On X- rays it appears to be a benign pneumoconiosis and is not associated with pulmonary fibrosis or disability unless there is concurrent exposure to other fibrosis producing materials such as silica. Overexposure to crystalline silica dust causes lung effects. There is sufficient evidence in humans for the carcinogenicity of inhaled crystalline silica (IARC 1,OSHA). Chronic inhalation of crystalline silica dust may cause kidney disease, auto-immune disease, and lymph node effects in humans. On the basis of extensive animal testing, C.I. Pigment Orange 5 should be considered an animal carcinogen by ingestion. It has also been determined to cause mutagenic effects in tests with bacteria both with and without activation. Liver effects have also been observed with animals. In general, uncorroborated case reports and in vitro studies, such as Ames tests, are useful pieces of information but are not definitive findings of hazard. C.I. Pigment 5 has been reported to show a positive Ames test and thereby may be characterized as an in vitro mutagen. Because this product is a free-flowing liquid or paste, dust inhalation is not an expected route of exposure.