3-(Trimethoxysilyl)propyl methacrylate

2.1 Classification of the substance or mixture

Note This chemical does not meet GHS hazard criteria for 83.6% (534 of 639) of all reports. scheme(5), an estimated BCF of 3.2(SRC), from an estimated log Kow of 0.75(6) and a regression- derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC). The hydrolysis of 3-methacryloxypropyl-trimethodxysilane proceeds within a few minutes in a low pH environment as a result of the catalytic action of H+ ions(8). Biodegradation data were not available(SRC, 2009). (1) Swann RL et al; Res Rev 85: 17-28 (1983) (2) Meylan WM et al; Environ Sci Technol 26: 1560-67 (1992) (3) Lyman WJ et al; Handbook of Chemical Property Estimation Methods. Washington, DC: Amer Chem Soc pp. 15-1 to 15-29 (1990) (4) Meylan WM, Howard PH; Environ Toxicol Chem 10: 1283-93 (1991) (5) Franke C et al; Chemosphere 29: 1501-14 (1994) (6) Meylan WM, Howard PH; J Pharm Sci 84: 83-92 (1995) (7) Meylan WM et al; Environ Toxicol Chem 18: 664-72 (1999) (8) Xanthos M; Functional Fillers for Plastics. Weinheim, Germany: Wiley-VCH p. 63 (2005) (UNECE) 17.4 EPA CPDat Classification EPA Chemical and Products Database (CPDat) 17.5 NORMAN Suspect List Exchange Classification NORMAN Suspect List Exchange 17.6 EPA DSSTox Classification EPA DSSTox 17.7 EPA TSCA and CDR Classification EPA Chemicals under the TSCA 17.8 EPA Substance Registry Services Tree EPA Substance Registry Services 17.9 MolGenie Organic Chemistry Ontology MolGenie 17.10 Chemicals in PubChem from Regulatory Sources PubChem 18 Information Sources FILTER BY SOURCE ALL SOURCES 1. Australian Industrial Chemicals Introduction Scheme (AICIS) LICENSE https://www.industrialchemicals.gov.au/copyright 2-Propenoic acid, 2-methyl-, 3-(trimethoxysilyl)propyl ester https://services.industrialchemicals.gov.au/search-assessments/ 2-Propenoic acid, 2-methyl-, 3-(trimethoxysilyl)propyl ester https://services.industrialchemicals.gov.au/search-inventory/ 2. CAS Common Chemistry LICENSE The data from CAS Common Chemistry is provided under a CC-BY-NC 4.0 license, unless otherwise stated. https://creativecommons.org/licenses/by-nc/4.0/ 3-(Trimethoxysilyl)propyl methacrylate https://commonchemistry.cas.org/detail?cas_rn=2530-85-0 3-(Trimethoxysilyl)propyl methacrylate homopolymer https://commonchemistry.cas.org/detail?cas_rn=52004-97-4 3. ChemIDplus LICENSE https://www.nlm.nih.gov/copyright.html Trimethoxysilylpropyl methacrylate https://pubchem.ncbi.nlm.nih.gov/substance/?source=chemidplus&sourceid=0002530850 ChemIDplus Chemical Information Classification https://pubchem.ncbi.nlm.nih.gov/source/chemidplus 4. DTP/NCI LICENSE Unless otherwise indicated, all text within NCI products is free of copyright and may be reused without our permission. Credit the National Cancer Institute as the source. https://www.cancer.gov/policies/copyright-reuse 3-(Trimethoxysilyl)propyl methacrylate https://dtp.cancer.gov/dtpstandard/servlet/dwindex?searchtype=NSC&outputformat=html&searchlist=93591 5. EFSA OpenFoodTox LICENSE https://www.efsa.europa.eu/en/legalnotice [3-(Methacryloxy)propyl]trimethoxysilane 6. EPA Chemical Data Reporting (CDR) LICENSE The U.S. Government retains a nonexclusive, royalty-free license to publish or reproduce these documents, or allow others to do so, for U.S. Government purposes. These documents may be freely distributed and used for non-commercial, scientific and educational purposes. https://www.epa.gov/web-policies-and-procedures/epa-disclaimers#copyright 2-Propenoic acid, 2-methyl-, 3-(trimethoxysilyl)propyl ester https://www.epa.gov/chemical-data-reporting 7. EPA Chemicals under the TSCA LICENSE https://www.epa.gov/privacy/privacy-act-laws-policies-and-resources 2-Propenoic acid, 2-methyl-, 3-(trimethoxysilyl)propyl ester https://www.epa.gov/chemicals-under-tsca EPA TSCA Classification https://www.epa.gov/tsca-inventory 8. EPA DSSTox LICENSE https://www.epa.gov/privacy/privacy-act-laws-policies-and-resources 3-(Trimethoxysilyl)propyl methacrylate https://comptox.epa.gov/dashboard/DTXSID3029237 CompTox Chemicals Dashboard Chemical Lists https://comptox.epa.gov/dashboard/chemical-lists/ 9. European Chemicals Agency (ECHA) LICENSE Use of the information, documents and data from the ECHA website is subject to the terms and conditions of this Legal Notice, and subject to other binding limitations provided for under applicable law, the information, documents and data made available on the ECHA website may be reproduced, distributed and/or used, totally or in part, for non-commercial purposes provided that ECHA is acknowledged as the source: "Source: European Chemicals Agency, http://echa.europa.eu/". Such acknowledgement must be included in each copy of the material. ECHA permits and encourages organisations and individuals to create links to the ECHA website under the following cumulative conditions: Links can only be made to webpages that provide a link to the Legal Notice page. https://echa.europa.eu/web/guest/legal-notice 3-trimethoxysilylpropyl methacrylate https://chem.echa.europa.eu/100.017.987 3-trimethoxysilylpropyl methacrylate (EC: 219-785-8) https://echa.europa.eu/information-on-chemicals/cl-inventory-database/-/discli/details/10222 10. FDA Global Substance Registration System (GSRS) LICENSE Unless otherwise noted, the contents of the FDA website (www.fda.gov), both text and graphics, are not copyrighted. They are in the public domain and may be republished, reprinted and otherwise used freely by anyone without the need to obtain permission from FDA. Credit to the U.S. Food and Drug Administration as the source is appreciated but not required. https://www.fda.gov/about-fda/about-website/website-policies#linking .GAMMA.-METHACRYLOXYPROPYLTRIMETHOXYSILANE https://gsrs.ncats.nih.gov/ginas/app/beta/substances/JV48X1M2EQ http://www.unece.org/trans/danger/publi/ghs/ghs_welcome_e.html 30. NORMAN Suspect List Exchange LICENSE Data CC-BY 4.0; Code (hosted by ECI, LCSB) Artistic-2.0 https://creativecommons.org/licenses/by/4.0/ NORMAN Suspect List Exchange Classification https://www.norman-network.com/nds/SLE/ 31. EPA Substance Registry Services LICENSE https://www.epa.gov/privacy/privacy-act-laws-policies-and-resources EPA SRS List Classification https://maldi.nist.gov 32. MolGenie LICENSE CC-BY 4.0 https://creativecommons.org/licenses/by/4.0/ MolGenie Organic Chemistry Ontology https://github.com/MolGenie/ontology/ 33. PATENTSCOPE (WIPO) SID 402572719 https://pubchem.ncbi.nlm.nih.gov/substance/402572719 SID 403034460 https://pubchem.ncbi.nlm.nih.gov/substance/403034460 Cite Download

Hazard pictograms

Irritant Signal Warning

Hazard statements

H315 (15%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (15%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335 (11.6%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary statements

Codes P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 ECHA C&L Notifications Summary Aggregated GHS information provided per 639 reports by companies from 16 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. Reported as not meeting GHS hazard criteria per 534 of 639 reports by companies. There are 14 notifications provided by 105 of 639 reports by companies with hazard statement code(s). Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. European Chemicals Agency (ECHA)

Hazard categories

and Categories Skin Irrit. 2 (15%) Eye Irrit. 2 (15%) STOT SE 3 (11.6%) European Chemicals Agency (ECHA) Summary A skin and eye irritant; [eChemPortal: ERMA] An irritant; [MSDSonline] See ACRYLIC RESINS (MONOMERS). Haz-Map, Information on Hazardous Chemicals and Occupational Diseases 11.1.4 Fire Potential Combustible; moderate fire risk Sax, N.I. and R.J. Lewis, Sr. (eds.). Hawley's Condensed Chemical Dictionary. 11th ed. New York: Van Nostrand Reinhold Co., 1987., p. 751

Hazardous Ingredients

Data Bank (HSDB) Will burn if involved in a fire ... Combustible liquid and vapor. Material Safety Data Sheet, rev #9 (June 19, 2008): 3-(Trimethoxysilyl)propyl methacrylate, ACC# 59817. Available from, as of October 25, 2009: https://fscimage.fishersci.com/msds/59817.htm Data Bank (HSDB) 11.1.5 Skin, Eye, and Respiratory Irritations A skin and eye irritant. Lewis, R.J. Sr. (ed) Sax's Dangerous Properties of Industrial Materials. 11th Edition. Wiley-Interscience, Wiley & Sons, Inc. Hoboken, NJ. 2004., p. 3576 Data Bank (HSDB) Causes respiratory tract irritation. May be harmful if inhaled. Material Safety Data Sheet, rev #9 (June 19, 2008): 3-(Trimethoxysilyl)propyl methacrylate, ACC# 59817. Available from, as of October 25, 2009: https://fscimage.fishersci.com/msds/59817.htm Data Bank (HSDB) May be harmful if inhaled. Causes respiratory tract irritation. May be harmful if absorbed through skin. Causes skin irritation. Causes eye irritation. Sigma-Aldrich; Safety Data Sheet for 3-(Trimethoxysilyl)propyl methacrylate (Product Number: M6514) Version 3.0 (August 22, 2009). Available from, as of November 25, 2009: https://www.sigmaaldrich.com Data Bank (HSDB) 11.2 Safety and Hazard Properties 11.2.1 Explosive Limits and Potential Lower 0.9 vol%; upper 5.4 vol% Material Safety Data Sheet, rev #9 (June 19, 2008): 3-(Trimethoxysilyl)propyl methacrylate, ACC# 59817. Available from, as of October 25, 2009: https://fscimage.fishersci.com/msds/59817.htm Data Bank (HSDB) Containers may explode in the heat of a fire. Material Safety Data Sheet, rev #9 (June 19, 2008): 3-(Trimethoxysilyl)propyl methacrylate, ACC# 59817. Available from, as of October 25, 2009: https://fscimage.fishersci.com/msds/59817.htm Data Bank (HSDB) 11.3 Fire Fighting 11.3.1 Fire Fighting Procedures Use water spray to cool fire-exposed containers. Use water spray, dry chemical, carbon dioxide, or appropriate foam. Material Safety Data Sheet, rev #9 (June 19, 2008): 3-(Trimethoxysilyl)propyl methacrylate, ACC# 59817. Available from, as of October 25, 2009: https://fscimage.fishersci.com/msds/59817.htm Data Bank (HSDB) As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Material Safety Data Sheet, rev #9 (June 19, 2008): 3-(Trimethoxysilyl)propyl methacrylate, ACC# 59817. Available from, as of October 25, 2009: https://fscimage.fishersci.com/msds/59817.htm Data Bank (HSDB) Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Sigma-Aldrich; Safety Data Sheet for 3-(Trimethoxysilyl)propyl methacrylate (Product Number: M6514) Version 3.0 (August 22, 2009). Available from, as of November 25, 2009: https://www.sigmaaldrich.com Data Bank (HSDB) Special protective equipment for fire-fighters: Wear self contained breathing apparatus for fire fighting if necessary. Sigma-Aldrich; Safety Data Sheet for 3-(Trimethoxysilyl)propyl methacrylate (Product Number: M6514) Version 3.0 (August 22, 2009). Available from, as of November 25, 2009: https://www.sigmaaldrich.com Data Bank (HSDB) 11.4 Accidental Release Measures 11.4.1 Cleanup Methods SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal. Data Bank (HSDB) Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Remove all sources of ignition. Use a spark-proof tool. Do not let this chemical enter the environment. Material Safety Data Sheet, rev #9 (June 19, 2008): 3-(Trimethoxysilyl)propyl methacrylate, ACC# 59817. Available from, as of October 25, 2009: https://fscimage.fishersci.com/msds/59817.htm Data Bank (HSDB) Methods for cleaning up: Soak up with inert absorbent material and dispose of as hazardous waste. Keep in suitable, closed containers for disposal. Personal precautions: Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Sigma-Aldrich; Safety Data Sheet for 3-(Trimethoxysilyl)propyl methacrylate (Product Number: M6514) Version 3.0 (August 22, 2009). Available from, as of November 25, 2009: https://www.sigmaaldrich.com Data Bank (HSDB) Environmental precautions: Do not let product enter drains. Sigma-Aldrich; Safety Data Sheet for 3-(Trimethoxysilyl)propyl methacrylate (Product Number: M6514) Version 3.0 (August 22, 2009). Available from, as of November 25, 2009: https://www.sigmaaldrich.com Data Bank (HSDB) Data Bank (HSDB) SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations. Data Bank (HSDB) 11.4.3 Preventive Measures ... Hazard is the generation of considerable exothermic heat in some of the reactions, so that high pressures & temp may develop. This danger ... should be borne in mind when designing plant. Awareness of the dangers and of good engineering design are essential to safety. Employees should be instructed about the necessity of cleansing the skin if it is contaminated by materials which are irritants or skin-absorbed. With careful design, however, and complete enclosure of those processes where toxic chemicals or intermediates occur, dangerous exposures can be avoided. / Acrylic acid & derivatives/ International Labour Office. Encyclopedia of Occupational Health and Safety. Vols. I&II. Geneva, Switzerland: International Labour Office, 1983., p. 53 Data Bank (HSDB) In case of skin contact: Wash off with soap and plenty of water. Consult a physician. Sigma-Aldrich; Safety Data Sheet for 3-(Trimethoxysilyl)propyl methacrylate (Product Number: M6514) Version 3.0 (August 22, 2009). Available from, as of November 25, 2009: https://www.sigmaaldrich.com Data Bank (HSDB) In case of eye contact: Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. Sigma-Aldrich; Safety Data Sheet for 3-(Trimethoxysilyl)propyl methacrylate (Product Number: M6514) Version 3.0 (August 22, 2009). Available from, as of November 25, 2009: https://www.sigmaaldrich.com Data Bank (HSDB) Hygiene measures: Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Sigma-Aldrich; Safety Data Sheet for 3-(Trimethoxysilyl)propyl methacrylate (Product Number: M6514) Version 3.0 (August 22, 2009). Available from, as of November 25, 2009: https://www.sigmaaldrich.com Data Bank (HSDB) For more Preventive Measures (Complete) data for Trimethoxysilylpropyl methacrylate (6 total), please visit the HSDB record page. Data Bank (HSDB) 11.5 Handling and Storage Data Bank (HSDB) Use explosion-proof ventilation equipment. Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Material Safety Data Sheet, rev #9 (June 19, 2008): 3-(Trimethoxysilyl)propyl methacrylate, ACC# 59817. Available from, as of October 25, 2009: https://fscimage.fishersci.com/msds/59817.htm Data Bank (HSDB) Temp during storage must be kept low to minimize formation of peroxides and other oxidation products. ... Storage temp below 30 °C are recommended for the polyfunctional methacrylates. ... The methacrylate monomers should not be stored for longer than one year. Shorter storage times are recommended for the aminomethacrylates, ie, three months, and the polyfunctional methacrylates, ie, six months. Many of these cmpd are sensitive to UV light and should, therefore, be stored in the dark. The methacrylic esters may be stored in mild steel, stainless steel, or aluminum. /Methacrylic acid & derivatives/ Kirk-Othmer Encyclopedia of Chemical Technology. 3rd ed., Volumes 1-26. New York, NY: John Wiley and Sons, 1978-1984., p. 15(81) 370 Data Bank (HSDB) Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8 °C Moisture sensitive. Handle and store under inert gas. Heat sensitive. Sigma-Aldrich; Safety Data Sheet for 3-(Trimethoxysilyl)propyl methacrylate (Product Number: M6514) Version 3.0 (August 22, 2009). Available from, as of November 25, 2009: https://www.sigmaaldrich.com Data Bank (HSDB) 11.6 Exposure Control and Personal Protection 11.6.1 Personal Protective Equipment (PPE) Personal Protective Equipment. Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Material Safety Data Sheet, rev #9 (June 19, 2008): 3-(Trimethoxysilyl)propyl methacrylate, ACC# 59817. Available from, as of October 25, 2009: https://fscimage.fishersci.com/msds/59817.htm Data Bank (HSDB) A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use. Material Safety Data Sheet, rev #9 (June 19, 2008): 3-(Trimethoxysilyl)propyl methacrylate, ACC# 59817. Available from, as of October 25, 2009: https://fscimage.fishersci.com/msds/59817.htm Data Bank (HSDB) Respiratory protection: Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multipurpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Sigma-Aldrich; Safety Data Sheet for 3-(Trimethoxysilyl)propyl methacrylate (Product Number: M6514) Version 3.0 (August 22, 2009). Available from, as of November 25, 2009: https://www.sigmaaldrich.com Data Bank (HSDB) Hand protection: The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Handle with gloves. Sigma-Aldrich; Safety Data Sheet for 3-(Trimethoxysilyl)propyl methacrylate (Product Number: M6514) Version 3.0 (August 22, 2009). Available from, as of November 25, 2009: https://www.sigmaaldrich.com Data Bank (HSDB) For more Personal Protective Equipment (PPE) (Complete) data for Trimethoxysilylpropyl methacrylate (6 total), please visit the HSDB record page. Data Bank (HSDB) 11.7 Stability and Reactivity 11.7.1 Hazardous Reactivities and Incompatibilities Incompatibilities with other materials: Strong oxidizing agents, strong acids, strong bases. Material Safety Data Sheet, rev #9 (June 19, 2008): 3-(Trimethoxysilyl)propyl methacrylate, ACC# 59817. Available from, as of October 25, 2009: https://fscimage.fishersci.com/msds/59817.htm Data Bank (HSDB) Materials to avoid: Strong oxidizing agents, strong acids, strong bases. Sigma-Aldrich; Safety Data Sheet for 3-(Trimethoxysilyl)propyl methacrylate (Product Number: M6514) Version 3.0 (August 22, 2009). Available from, as of November 25, 2009: https://www.sigmaaldrich.com Data Bank (HSDB) 11.8 Regulatory Information The Australian Inventory of Industrial Chemicals Chemical: 2-Propenoic acid, 2-methyl-, 3-(trimethoxysilyl)propyl ester Australian Industrial Chemicals Introduction Scheme (AICIS) EFSA Legal Basis Regulation (EC) No 1935/2004 (amended) EFSA OpenFoodTox REACH Registered Substance Status Active Update 16-02-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/15277 European Chemicals Agency (ECHA) New Zealand EPA Inventory of Chemical Status 3-(Trimethoxysilyl)propyl methacrylate: Does not have an individual approval but may be used under an appropriate group standard New Zealand Environmental Protection Authority (EPA) 11.8.1 TSCA Requirements Section 8(a) of TSCA requires manufacturers of this chemical substance to report preliminary assessment information concerned with production, use, and exposure to EPA as cited in the preamble of 51 FR 41329. 40 CFR 712.30 (7/1/88) Data Bank (HSDB) 11.9 Other Safety Information Chemical Assessment Evaluation - Chemicals that are unlikely to require further regulation to manage risks to environment Australian Industrial Chemicals Introduction Scheme (AICIS) 11.9.1 Toxic Combustion Products Hazardous decomposition products formed under fire conditions: Carbon oxides, silicon oxides. Sigma-Aldrich; Safety Data Sheet for 3-(Trimethoxysilyl)propyl methacrylate (Product Number: M6514) Version 3.0 (August 22, 2009). Available from, as of November 25, 2009: https://www.sigmaaldrich.com Data Bank (HSDB) 12 Toxicity Data Bank (HSDB) /SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Anticipate seizures and treat if necessary ... . Monitor for shock and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal (refer to ingestion protocol in Section Three ... . Cover skin burns with sterile dressings after decontamination ... . /Silane, Chlorosilane, and Related Compounds/ Currance, P.L. Clements, B., Bronstein, A.C. (Eds).; Emergency Care For Hazardous Materials Exposure. 3Rd edition, Elsevier Mosby, St. Louis, MO 2005, p. 486-7 Data Bank (HSDB) /SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Early intubation at the first sign of upper airway obstruction may be necessary. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Silane, Chlorosilane, and related compounds/ Currance, P.L. Clements, B., Bronstein, A.C. (Eds).; Emergency Care For Hazardous Materials Exposure. 3Rd edition, Elsevier Mosby, St. Louis, MO 2005, p. 487 Data Bank (HSDB) /SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Esters and related compounds/ Currance, P.L. Clements, B., Bronstein, A.C. (Eds).; Emergency Care For Hazardous Materials Exposure. 3Rd edition, Elsevier Mosby, St. Louis, MO 2005, p. 253 Data Bank (HSDB) For more Antidote and Emergency Treatment (Complete) data for Trimethoxysilylpropyl methacrylate (6 total), please visit the HSDB record page. Data Bank (HSDB) 12.1.4 Human Toxicity Excerpts /OTHER TOXICITY INFORMATION/ Biologically, methacrylates resemble acrylates, except for lower reactivity and thus decr toxicity. This is probably due to steric hindrance by its methyl group and in turn decr rates of membrane transport and systemic translocation. /Methacrylic esters/ Clayton, G. D. and F. E. Clayton (eds.). Patty's Industrial Hygiene and Toxicology Volume 2A, 2B, 2C Toxicology. 3rd ed. New York John Wiley Sons, 1981-1982., p. 2298 Data Bank (HSDB) 12.1.5 Non-Human Toxicity Excerpts /LABORATORY ANIMALS: Acute Exposure/ Applied to the skin and mouth mucosa of rats, gamma- methacryloxypropyl trimethoxysilane had no effect. Takagi M et al; Nippon Kokuka Gakkai Zasshi 22 (4): 533-49 (1973) Data Bank (HSDB) 12.1.6 Non-Human Toxicity Values LD50 Rat oral 23.5 g/kg Material Safety Data Sheet, rev #9 (June 19, 2008): 3-(Trimethoxysilyl)propyl methacrylate, ACC# 59817. Available from, as of October 25, 2009: https://fscimage.fishersci.com/msds/59817.htm Data Bank (HSDB) 12.1.7 TSCA Test Submissions 2-Propionic acid, 2-methyl, 3-(trimethoxysilyl)propyl ester (silane A-174) was evaluated for the ability to increase the incidence of micronucleated polychromatic erythrocytes in peripheral blood samples of male and female Swiss- Webster mice treated by I.P. injection. Groups of 10 mice (5 male and 5 female) received a single dose of 2500, 4000, 5000 mg/kg body weight of test article in corn oil; blood samples were drawn 30, 48 and 72 hours after injection. A statistically significant increase in the incidence of micronucleated polychromatic erythrocytes was not observed (Fischer exact test, p > 0.001) at any dose level or time of sampling. A statistically significant (linear regression analysis, r = -0.97) dose related decrease in the PCE/NCE ratio was observed at the 72 hour sampling time (all doses), reflecting the toxic effect of the test article. Additionally, in a preliminary toxicity test, administration of 5000 mg/kg test article (maximum testable dose) induced a 25% decrease in the polychromatic to normochromatic erythrocyte (PCE/NCE) ratio, while mortality was not observed at doses up to and including this level. Bushy Run Research Center; Silane A-174: In Vivo Mouse Micronucleus Study (1986), EPA Document No. FYI-OTS-0386-0469, Fiche No. OTS0000469-0 Data Bank (HSDB) The frequency of chromosomal aberrations was determined in Chinese Hamster Ovary (CHO) cells exposed to 2- propionic acid, 2-methyl, 3-(trimethoxysilyl)propyl ester (silane A-174) with and without metabolic activation provided by Aroclor-induced rat liver S9 fraction. CHO-K1-BH4 cells were exposed to test article at concentrations ranging from 0.1 to 0.6 mg/ml in the presence and absence of activation, and samples were withdrawn at 8 and 12 hours for evaluation. In activated tests, statistically significant (Fischer's exact test, p < 0.05) increases in the incidences of aberrations were observed in samples withdrawn at 8 hours from cultures exposed to 0.3, 0.4, and 0.6 mg/ml, and in samples withdrawn at 12 hours from cultures exposed to 0.2 and 0.3 mg/ml. Additionally, it was reported that the frequency of sister chromatid exchange was increased in the 12 hour samples . A statistically significant (p < 0.01) increase in the incidence of aberrations was observed in samples withdrawn at 8 hours from nonactivated cultures exposed to 0.4 mg/ml. In preliminary range finding tests, exposure of cells to test article at a concentration of 0.5 mg/ml with activation reduced the percentage of mitotic cells by 62.1%, while exposure to 0.6 mg/ml without activation resulted in a 44.4% decrease. Bushy Run Research Center; Silane A-174: In Vitro Cytogenetic Testing with Chinese Hamster Ovary Cells (1985), EPA Document No. FYI-OTS-0386-0469, Fiche No. OTS0000469-0 Data Bank (HSDB) The ability of methacryloxypropyltrimethoxysilane (MPTS) to induce mutations at the HGPRT gene locus in Chinese Hamster Ovary (CHO) cells in vitro was evaluated in the presence and absence of Aroclor-induced rat liver S9 metabolic activation. Based on preliminary toxicity determinations, MPTS was tested for mutagenicity at concentrations of 0.2, 0.4, 0.6, 0.7 or 0.8 mg/ml without activation and at concentrations of 0.1, 0.2, 0.4, 0.6, 0.7 or 0.8 mg/ml with activation. Cell survival ranged from 108 - 156% without activation and from 42 - 105% with activation. There were no significant differences between treated and control (methanol solvent vehicle) cultures with respect to mutation frequencies at any of the concentrations tested, either with or without activation. Bushy Run Research Center, Union Carbide Corp.; Methacryloxypropyltrimethoxysilane In Vitro Studies: CHO/HGPRT Gene Mutation Test, Sister Chromatid Exchange Assay. (1985), EPA Document No. FYI-OTS-0386-0469 Data Bank (HSDB) View More... Data Bank (HSDB) 12.2.2 Artificial Pollution Sources Trimethoxysilylpropyl methacrylate's production and use as an adhesion(1) or coupling agent to dental porcelain, ceramic, or glass(2) surfaces may result in its release to the environment through various waste streams(SRC). (1) Lewis RJ Sr; Hawley's Condensed Chemical Dictionary 15th ed. John Wiley & Sons, Inc., New York, NY, p 809 (2007) (2) Tesk JA et al; Kirk-Othmer Encyclopedia of Chemical Technology. (2001). New York, NY: John Wiley & Sons; Dental Materials. Online Posting Date: Oct. 18, 2002. Data Bank (HSDB) 12.2.3 Environmental Fate TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 1,700(SRC), determined from a structure estimation method(2), indicates that trimethoxysilylpropyl methacrylate is expected to have low mobility in soil(SRC). Volatilization of trimethoxysilylpropyl methacrylate from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 3.0X10-7 atm-cu m/mole(SRC), by using a fragment constant estimation method(3). Trimethoxysilylpropyl methacrylate is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 0.44 mm Hg at 25 °C(SRC), determined from a fragment constant method(4). Biodegradation data were not available(SRC, 2009). (1) Swann RL et al; Res Rev 85: 17-28 (1983) (2) Meylan WM et al; Environ Sci Technol 26: 1560-67 (1992) (3) Meylan WM, Howard PH; Environ Toxicol Chem 10: 1283-93 (1991) (4) Lyman WJ; p. 31 in Environmental Exposure From Chemicals Vol I, Neely WB, Blau GE, eds, Boca Raton, FL: CRC Press (1985) Data Bank (HSDB) AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 1,700(SRC), determined from a structure estimation method(2), indicates that trimethoxysilylpropyl methacrylate is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 3.0X10-7 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). According to Data Bank (HSDB) ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), trimethoxysilylpropyl methacrylate, which has an estimated vapor pressure of 0.44 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist solely in the vapor phase in the ambient atmosphere. Vapor-phase trimethoxysilylpropyl methacrylate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 15 hours(SRC), calculated from its rate constant of 2.5X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). The atmospheric half-life for the vapor-phase reaction of trimethoxysilylpropyl methacrylate with ozone has been estimated as 24 hours at an atmospheric concentration of 7X10+11 ozone molecules per cu cm(4). Trimethoxysilylpropyl methacrylate does not contain chromophores that absorb at wavelengths >290 nm(5) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC). (1) Bidleman TF; Environ Sci Technol 22: 361-367 (1988) (2) Lyman WJ; p. 31 in Environmental Exposure From Chemicals Vol I, Neely WB, Blau GE, eds, Boca Raton, FL: CRC Press (1985) (3) Meylan WM, Howard PH; Chemosphere 26: 2293-99 (1993) (4) Atkinson R, Carter WPL; Chem Rev 84: 437-70 (1984) (5) Lyman WJ et al; Handbook of Chemical Property Estimation Methods. Washington, DC: Amer Chem Soc pp. 8-12 (1990) Data Bank (HSDB) 12.2.4 Environmental Abiotic Degradation The rate constant for the vapor-phase reaction of trimethoxysilylpropyl methacrylate with photochemically-produced hydroxyl radicals has been estimated as 2.5X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 15 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). The rate constant for the vapor-phase reaction of trimethoxysilylpropyl methacrylate with ozone has been estimated as 1.1X10-17 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(1). This corresponds to an atmospheric half-life of about 24 hours at an atmospheric concentration of 7X10+11 ozone molecules per cu cm(2). A base-catalyzed second-order hydrolysis rate constant of 2.7X10-3 L/mole-sec(SRC) was estimated using a structure estimation method(3); this corresponds to half-lives of 81 and 8.1 years at pH values of 7 and 8, respectively(3). Trimethoxysilylpropyl methacrylate does not contain chromophores that absorb at wavelengths >290 nm(4) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC). (1) Meylan WM, Howard PH; Chemosphere 26: 2293-99 (1993) (2) Atkinson R, Carter WPL; Chem Rev 84: 437-70 (1984) (3) Mill T et al; Environmental Fate and Exposure Studies Development of a PC-SAR for Hydrolysis: Esters, Alkyl Halides and Epoxides. EPA Contract No. 68-02-4254. Menlo Park, CA: SRI International (1987) (4) Lyman WJ et al; Handbook of Chemical Property Estimation Methods. Washington, DC: Amer Chem Soc pp. 8-12 (1990) Data Bank (HSDB) The hydrolysis of 3-methacryloxypropyl trimethoxy silane was carried out in an ethanol/water 80/20 (w/w) solution under acidic, alkaline and neutral conditions, and it was found that the kinetic rate of the hydrolysis under neutral conditions was very low; the addition of triethylamine catalyzed both silane hydrolysis and self condensation reactions(1). Acidic conditions enhanced the hydrolysis and the ensuing silanol entities were quite stable; in fact, these conditions slowed down the rate of the self condensation reactions(1). At high and very low pH values, the rate of hydrolysis is higher than at the neutral pH, at which silanes are most stable; the hydrolysis of 3- methacryloxypropyl-trimethoxysilane proceeds within a few minutes in a low pH environment as a result of the catalytic action of H+ ions(2). (1) Salon MCB et al; Colloids Surf A 312: 83-91 (2007) (2) Xanthos M; Functional Fillers for Plastics. Weinheim, Germany: Wiley-VCH p. 63 (2005) Data Bank (HSDB) 12.2.5 Environmental Bioconcentration An estimated BCF of 3.2 was calculated for trimethoxysilylpropyl methacrylate(SRC), using an estimated log Kow of 0.75(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). (1) Meylan WM, Howard PH; J Pharm Sci 84: 83-92 (1995) (2) Meylan WM et al; Environ Toxicol Chem 18: 664-72 (1999) (3) Franke C et al; Chemosphere 29: 1501-14 (1994) Data Bank (HSDB) 12.2.6 Soil Adsorption / Mobility Using a structure estimation method based on molecular connectivity indices(1), the Koc of trimethoxysilylpropyl methacrylate can be estimated to be 1,700(SRC). According to a classification scheme(2), this estimated Koc value suggests that trimethoxysilylpropyl methacrylate is expected to have low mobility in soil. (1) Meylan WM et al; Environ Sci Technol 26: 1560-67 (1992) (2) Swann RL et al; Res Rev 85: 17-28 (1983) Data Bank (HSDB) 12.2.7 Volatilization from Water / Soil The Henry's Law constant for trimethoxysilylpropyl methacrylate is estimated as 3.0X10-7 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that trimethoxysilylpropyl methacrylate is expected to be essentially nonvolatile from water surfaces(2). The Henry's Law constant for trimethoxysilylpropyl methacrylate indicates that volatilization from moist soil surfaces will not occur(SRC). Trimethoxysilylpropyl methacrylate is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 0.44 mm Hg(SRC), determined from a fragment constant method(3). (1) Meylan WM, Howard PH; Environ Toxicol Chem 10: 1283-93 (1991) (2) Lyman WJ et al; Handbook of Chemical Property Estimation Methods. Washington, DC: Amer Chem Soc pp. 15-1 to 15-29 (1990) (3) Lyman WJ; p. 31 in Environmental Exposure From Chemicals Vol I, Neely WB, Blau GE, eds, Boca Raton, FL: CRC Press (1985) Data Bank (HSDB) 12.2.8 Other Environmental Concentrations Occupational exposure to trimethoxysilylpropyl methacrylate may occur through inhalation and dermal contact with this compound at workplaces where trimethoxysilylpropyl methacrylate is produced or used. The most likely pathway by which the general public is exposed to trimethoxysilylpropyl methacrylate is by ingestion or dermal contact during porcelain dental repair work. (SRC) Data Bank (HSDB) 12.3 EFSA OpenFoodTox 12.3.1 EFSA Outputs EFSA OpenFoodTox 12.3.2 EFSA Hazard Characterization: Reference Values EFSA OpenFoodTox 12.3.3 EFSA Genotoxicity EFSA OpenFoodTox 13 Associated Disorders and Diseases Associated Occupational Diseases with Exposure to the Compound Contact dermatitis, allergic [Category: Skin Disease] Haz-Map, Information on Hazardous Chemicals and Occupational Diseases 14 Literature 14.1 Consolidated References PubChem 14.2 NLM Curated PubMed Citations Medical Subject Headings (MeSH) 14.3 Springer Nature References Springer Nature 14.4 Thieme References Thieme Chemistry 14.5 Wiley References Wiley 14.6 Chemical Co-Occurrences in Literature PubChem 14.7 Chemical-Gene Co-Occurrences in Literature PubChem 14.8 Chemical-Disease Co-Occurrences in Literature PubChem 14.9 Chemical-Organism Co-Occurrences in Literature PubChem 15 Patents 15.1 Depositor-Supplied Patent Identifiers PubChem Link to all deposited patent identifiers PubChem 15.2 WIPO PATENTSCOPE Patents are available for this chemical structure: https://patentscope.wipo.int/search/en/result.jsf?inchikey=OXNKFSFOKCIWJK-UHFFFAOYSA-N PATENTSCOPE (WIPO) Patents are available for this chemical structure: https://patentscope.wipo.int/search/en/result.jsf?inchikey=XDLMVUHYZWKMMD-UHFFFAOYSA-N PATENTSCOPE (WIPO) 15.3 Chemical Co-Occurrences in Patents PubChem 15.4 Chemical-Disease Co-Occurrences in Patents PubChem 15.5 Chemical-Gene Co-Occurrences in Patents PubChem 15.6 Chemical-Organism Co-Occurrences in Patents PubChem 16 Biological Test Results 16.1 BioAssay Results PubChem 17.1 MeSH Tree Medical Subject Headings (MeSH) 17.2 ChemIDplus ChemIDplus Data Bank (HSDB) LICENSE https://www.nlm.nih.gov/web_policies.html Trimethoxysilylpropyl methacrylate https://pubchem.ncbi.nlm.nih.gov/source/hsdb/5468 12. New Zealand Environmental Protection Authority (EPA) LICENSE This work is licensed under the Creative Commons Attribution-ShareAlike 4.0 International licence. https://www.epa.govt.nz/about-this-site/general-copyright-statement/ 3-(Trimethoxysilyl)propyl methacrylate https://www.epa.govt.nz/industry-areas/hazardous-substances/guidance-for-importers-and-manufacturers/hazardous-substances-databases/ 13. ChEMBL LICENSE Access to the web interface of ChEMBL is made under the EBI's Terms of Use (http://www.ebi.ac.uk/Information/termsofuse.html). The ChEMBL data is made available on a Creative Commons Attribution-Share Alike 3.0 Unported License (http://creativecommons.org/licenses/by-sa/3.0/). http://www.ebi.ac.uk/Information/termsofuse.html https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1887024 14. EPA Chemical and Products Database (CPDat) LICENSE https://www.epa.gov/privacy/privacy-act-laws-policies-and-resources 3-(Trimethoxysilyl)propyl methacrylate https://comptox.epa.gov/dashboard/DTXSID3029237#exposure EPA CPDat Classification https://www.epa.gov/chemical-research/chemical-and-products-database-cpdat 15. Haz-Map, Information on Hazardous Chemicals and Occupational Diseases LICENSE Copyright (c) 2022 Haz-Map(R). All rights reserved. Unless otherwise indicated, all materials from Haz-Map are copyrighted by Haz-Map(R). No part of these materials, either text or image may be used for any purpose other than for personal use. Therefore, reproduction, modification, storage in a retrieval system or retransmission, in any form or by any means, electronic, mechanical or otherwise, for reasons other than personal use, is strictly prohibited without prior written permission. https://haz-map.com/About Trimethoxysilylpropyl methacrylate https://haz-map.com/Agents/7605 16. FDA Packaging & Food Contact Substances (FCS) LICENSE https://www.fda.gov/about-fda/about-website/website-policies#linking TRIMETHOXYSILYLPROPYLMETHACRYLATE https://www.hfpappexternal.fda.gov/scripts/fdcc/index.cfm?set=IndirectAdditives 17. Japan Chemical Substance Dictionary (Nikkaji) http://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J7.602C 18. MassBank Europe LICENSE https://github.com/MassBank/MassBank-web/blob/main/MassBank-Project/LICENSE.txt 3-(Trimethoxysilyl)propyl methacrylate https://massbank.eu/MassBank/search?inchi_key=XDLMVUHYZWKMMD-UHFFFAOYSA-N 19. NIST Mass Spectrometry Data Center LICENSE Data covered by the Standard Reference Data Act of 1968 as amended. https://www.nist.gov/srd/public-law 2-Propenoic acid, 2-methyl-, 3-(trimethoxysilyl)propyl ester http://www.nist.gov/srd/nist1a.cfm 20. SpectraBase 1-Propanol, 3-(trimethoxysilyl)-, methacrylate https://spectrabase.com/spectrum/7efh7IPJGNn DYNASYLAN MEMO https://spectrabase.com/spectrum/LdRhFmV12A2 Methacryloxypropyl trimethoxysilane https://spectrabase.com/spectrum/IA8a4LoST9J 3-(TRIMETHOXYSILYL)-1-PROPANOL, METHACRYLATE https://spectrabase.com/spectrum/4huX8uTuKSk methacrylic acid, 3-(trimethoxysilyl)propyl ester https://spectrabase.com/spectrum/21mZtUTyuIj 3-METHACRYLOXYPROPYLTRIMETHOXYSILANE https://spectrabase.com/spectrum/7yJlnDfcJvv [3-(METHACRYLOYLOXY)-PROPYL]-TRIMETHOXYSILANE https://spectrabase.com/spectrum/LCPRIO0BF67 METHACRYLIC ACID, 3-/TRIMETHOXY- SILYL/PROPYL ESTER https://spectrabase.com/spectrum/EGgJViH8bxs 21. NMRShiftDB https://pubchem.ncbi.nlm.nih.gov/substance/87692239 22. Springer Nature https://pubchem.ncbi.nlm.nih.gov/substance/341149212 23. SpringerMaterials 3-(trimethoxy-silyl)-propyl methacrylate https://materials.springer.com/substanceprofile/docs/smsid_jzbkakptbxhhmxyr 24. Thieme Chemistry LICENSE The Thieme Chemistry contribution within PubChem is provided under a CC-BY-NC-ND 4.0 license, unless otherwise stated. https://creativecommons.org/licenses/by-nc-nd/4.0/ https://pubchem.ncbi.nlm.nih.gov/substance/517348036 25. Wikidata LICENSE CCZero https://creativecommons.org/publicdomain/zero/1.0/ γ-methacryloxypropyltrimethoxysilane https://www.wikidata.org/wiki/Q27281709 26. Wiley https://pubchem.ncbi.nlm.nih.gov/substance/386266421 27. Medical Subject Headings (MeSH) LICENSE Works produced by the U.S. government are not subject to copyright protection in the United States. Any such works found on National Library of Medicine (NLM) Web sites may be freely used or reproduced without permission in the U.S. https://www.nlm.nih.gov/copyright.html 3-(trimethoxysilyl)propyl methacrylate https://id.nlm.nih.gov/mesh/M0491883.html MeSH Tree https://www.nlm.nih.gov/mesh/meshhome.html 28. PubChem https://pubchem.ncbi.nlm.nih.gov 29. GHS Classification (UNECE)

Disposal

Methods This combustible material may be burned in a chemical incinerator equipped with an afterburner and scrubber. Observe all federal, state, and local environmental regulations. Contact a licensed professional waste disposal service to dispose of this material. Sigma-Aldrich; Safety Data Sheet for 3-(Trimethoxysilyl)propyl methacrylate (Product Number: M6514) Version 3.0 (August 22, 2009). Available from, as of November 25, 2009: https://www.sigmaaldrich.com

Storage

Conditions Keep away from sources of ignition. Store in a cool, dry place. Store in a tightly closed container. Store protected from moisture. Store under nitrogen. Material Safety Data Sheet, rev #9 (June 19, 2008): 3-(Trimethoxysilyl)propyl methacrylate, ACC# 59817. Available from, as of October 25, 2009: https://fscimage.fishersci.com/msds/59817.htm

TOXICOLOGICAL INFORMATION

12.1.1 Adverse Effects Skin Sensitizer - An agent that can induce an allergic reaction in the skin. Haz-Map, Information on Hazardous Chemicals and Occupational Diseases 12.1.2 Acute Effects ChemIDplus 12.1.3 Antidote and Emergency Treatment /SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Silane, Chlorosilane, and Related Compounds/ Currance, P.L. Clements, B., Bronstein, A.C. (Eds).; Emergency Care For Hazardous Materials Exposure. 3Rd edition, Elsevier Mosby, St. Louis, MO 2005, p. 486

ECOLOGICAL INFORMATION

12.2.1 Environmental Fate / Exposure Summary Trimethoxysilylpropyl methacrylate's production and use as an adhesion or coupling agent to dental porcelain, ceramic, or glass surfaces may result in its release to the environment through various waste streams. If released to air, an estimated vapor pressure of 0.44 mm Hg at 25 °C indicates trimethoxysilylpropyl methacrylate will exist solely as a vapor in the atmosphere. Vapor-phase trimethoxysilylpropyl methacrylate will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 15 hours. The atmospheric half-life for the vapor-phase reaction of trimethoxysilylpropyl methacrylate with ozone has been estimated as 24 hours. Trimethoxysilylpropyl methacrylate does not contain chromophores that absorb at wavelengths >290 nm and therefore is not expected to be susceptible to direct photolysis by sunlight. If released to soil, trimethoxysilylpropyl methacrylate is expected to have low mobility based upon an estimated Koc of 1,700. Volatilization from moist soil surfaces is not expected to be an important fate process based upon an estimated Henry's Law constant of 3.0X10-7 atm-cu m/mole. Trimethoxysilylpropyl methacrylate is not expected to volatilize from dry soil surfaces based upon its vapor pressure. Biodegradation data were not available. If released into water, trimethoxysilylpropyl methacrylate is expected to adsorb to suspended solids and sediment based upon the estimated Koc. Volatilization from water surfaces is not expected to be an important fate process based upon this compound's estimated Henry's Law constant. An estimated BCF of 3.2 suggests the potential for bioconcentration in aquatic organisms is low. The hydrolysis of 3-methacryloxypropyl-trimethodxysilane proceeds within a few minutes in a low pH environment as a result of the catalytic action of H+ ions. A base-catalyzed second-order hydrolysis rate constant of 2.7X10-3 L/mole-sec was estimated using a structure estimation method; this corresponds to half-lives of 81 and 8.1 years at pH values of 7 and 8, respectively. Occupational exposure to trimethoxysilylpropyl methacrylate may occur through inhalation and dermal contact with this compound at workplaces where trimethoxysilylpropyl methacrylate is produced or used. Monitoring data indicate that the general population may be exposed to trimethoxysilylpropyl methacrylate by ingestion or dermal contact during porcelain dental repair work. (SRC)

Contains

Title and Summary 1 Structures 2 Names and Identifiers 3 Chemical and Physical Properties 4 Spectral Information 5 Related Records 6 Chemical Vendors 7 Food Additives and Ingredients 8 Pharmacology and Biochemistry 9 Use and Manufacturing 10 Identification 11 Safety and Hazards 12 Toxicity 13 Associated Disorders and Diseases 14 Literature 15 Patents 16 Biological Test Results 17 Classification