CAS REGISTRY NO

Principle Routes of Exposure

Inhalation; skin; eyes; ingestion. IRRITATION DATA: Contact may be irritating to the skin and eyes. Inhalation of dusts may be irritating to the upper respiratory tract. INHALATION: ACUTE: May cause irritation to the eyes, nose, and lungs. May increase the incidence of upper respiratory infections. Breathing large amounts of dust or fume can result in “metal fume fever”, characterized by fever, chills, nausea and vomiting, muscular aches, and weakness. Inhalation of fumes from overheating of polytetrafluoroethylene may cause polymer fume fever. Symptoms of this flu-like illness include fever, chills, and cough and last approximately 24 hours. CHRONIC: Prolonged inhalation of manganese may cause primary inflammatory reaction in the lung, similar to pneumonia, without the presence of pathogenic bacteria. Prolonged overexposure to manganese may impair the central nervous system. Early symptoms include sluggishness, sleepiness, and weakness in the legs. Advanced cases have shown fixed facial expression, emotional disturbance, spastic gait, and falling. SKIN CONTACT: ACUTE: May cause irritation with redness and itching. CHRONIC: Prolonged exposure may cause dermatitis. EYE CONTACT: ACUTE: May cause severe irritation or corrosion to eye tissue. CHRONIC: May cause conjunctivitis. Components may cause poor pupil reaction to light, retinal damage, and blindness. INGESTION: ACUTE: May cause irritation, abdominal pain, and nausea. Inorganic manganese salts may produce hypoglycemia and decreased blood calcium levels. Ingested material is slowly and incompletely absorbed into body tissue. CHRONIC: Repeated ingestion may cause lethargy and edema.

Medical Conditions Generally Aggravated by Exposure

Breathing dusts or fumes may aggravate asthma and inflammatory or fibrotic pulmonary disease. Persons with a history of skin, eye, respiratory, or central nervous system disease may be at increased risk from exposure. Iron deficiency may increase susceptibility to manganese poisoning.