Levofloxacin Hemihydrate, USP

Hazard statements (CLP)

H302

Code

Statements

H302

Harmful if swallowed

Physical hazards

Not classified.

Health hazards

Acute toxicity, oral Category 4

Environmental hazards

Not classified.

Hazard pictograms

GHS07.

Signal word

Warning

Hazard statements

H302 Harmful if swallowed; P301+P312 If swallowed: Call a poison center/doctor if you feel unwell;P330 Rinse mouth; P501 Dispose of contents/container in accordance with local/regional/national/international regulations.

2.3 Other hazards

Not classified

Other hazards which do not result in classification

None known (Continued) Eye Contact: If applied to the eyes, this material causes severe eye damage. Phototoxic agents such as sulfonamides can cause inflammation of the conjunctiva and cornea, and clouding. Inhalation: The material is not thought to produce respiratory irritation (as classified using animal models). Nevertheless, inhalation of dusts, or fume, especially for prolonged periods, may produce respiratory discomfort and occasionally, distress. Inhalation of dusts, generated by the material during the course of normal handling, may be damaging to the health of the individual. Persons with impaired respiratory function, airway diseases and conditions such as emphysema or chronic bronchitis, may incur further disability if excessive concentrations of particulate are inhaled. Clinical signs of quinoline intoxication include lethargy, respiratory distress and prostration leading to coma. Ingestion: Accidental ingestion of the material may be damaging to the health of the individual. Fluoroquinolones have been associated with kidney damage, effects after exposure to UV light, seizures, changes in blood sugar levels (especially in diabetics), and crystal formation in the urine. They can also cause disease in the joints. After skin contact: Skin contact is not thought to have harmful health effects, however the material may still produce health damage following entry through wounds, lesions or abrasions. There is some evidence to suggest that this material can cause inflammation of the skin on contact in some persons. Open cuts, abraded or irritated skin should not be exposed to this material. Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably protected. Exposure to this product can cause sensitization of skin under sunlight. The product can reach the skin via the bloodstream either if swallowed or ingested.

Potential chronic health

Limited evidence suggests that repeated or long-term occupational exposure may produce cumulative health effects involving organs or biochemical systems. Prolonged or repeated use of antibiotics, at therapeutic doses, may produce bacterial resistance for some types of bacteria. Prolonged use may result in the overgrowth of non-susceptible organisms (i.e. Long term exposure to high dust concentrations may cause changes in lung function i.e. pneumoconiosis; caused by particles less than 0.5 micron penetrating and remaining in the lung.