(continued) ~----------- Containg no hazardous components (one percent or greater)

Health hazards

INFORMATION -~--------------- Human - Occupational Serr SS SS SSS eee Se eee Effects, Including Signs and Symptoms, of Exposure: Capsules and tablets are intended for human consumption under guidance of a physician. Capsules and tablets are not considered hazardous under normal handling procedures. Allergic reactions to cephalexin monohydrate have been reported. Allergic reactions to contents of capsules or to the powder used to make the tablets may include rash, nasal congestion, cough, dry throat, gastrointestinal upset, eye irritation, or anaphylactic shock.

Medical Conditions Generally Aggravated by Exposure

Penicillin or cephalosporin hypersensitivity. Primary Route(s) of Entry: Inhalation and skin contact. Exposure Guidelines: Cephalexin Capsules and Tablets - PEL and TLV not established. Cephalexin monohydrate - LEG 5.0 mg/m3 TWA for 12 hours 09 DP 9617 MAY 91 ELI LILLY AND COMPANY * LILLY CORPORATE CENTER * INDIANAPOLIS, INDIANA 46285 MSDS MATERIAL SAFETY DATA SHEET Page 4 COMMON NAME: Cephalexin Capsules and Tablets (Lilly Nos.: PU0402, PU0403, TA1872, TA1894, TA1895, TAL896, TA4053, TA4090, TASO91, TA4202, TA4203, UC5010, - UC5011, UC5346, UC5347, UC5348, UC5349, UEO001, UEO0O2, VFOO77, VFOO90, VFO092, VFQ122, VFO155, VFO254, VFO255, VF0256, VFO257, VF0264, VF0O265, VFO273, VFO291, VF0292) Date: July 1, 1993 ---+------+- SECTION 5 - HEALTH HAZARD INFORMATION (continued) ----------- Animal Toxicity Data Single Exposure Data for the active ingredient, cephalexin, are reported. Oral: Cephalexin - Rat, 5000 mg/kg, no deaths, increased urine output, weight loss. Monkey, 1000 mg/kg, no deaths, diarrhea. | Skin: Cephalexin - Rabbit, 153 mg/kg, no deaths or toxicity. Inhalation: Cephalexin - NAIF Intravenous: Cephalexin - Rat, 700 mg/kg, no deaths or toxicity. Dog, 100 mg/kg, no deaths, vomiting, tarry stools. Skin Contact: Cephalexin - Rabbit, nonirritant Eye Contact: Cephalexin - Rabbit, slight irritant Animal Toxicity Data Repeat Exposure CE en Ni inl i Eh i Nr i el Data for the active ingredient, cephalexin, are reported. Target Organ Effects: Cephalexin - None identified. Other Effects: Cephalexin - Salivation and vomiting. Reproduction: Cephalexin - No reproductive or developmental effects. Sensitization: Cephalexin - NAIF Mutagenicity: Cephalexin - Not mutagenic in bacterial cells. Carcinogenicity: No carcinogenicity data found. Not listed as carcinogenic by IARC, NCI/NTP, ACGIH,