General Information
Version
1.2.0
Revision date
2016-10-14
Product name
Lenvima ; Kisplyx
Product Synonyms
4-[3-(Chloro-4-(N"-cyclopropylureido)phenoxy]-7-methoxyquinoline-6- carboxamide methanesulfonate; ER-203492-13; E7080; HOPE
Chemical name
Mesylate salt
1.2.1 Relevant identified uses
Active pharmaceutical ingredient for research and development purposes; under of the substance or investigation to treat cancer mixture and uses
Emergency telephone
+1 (800) 424-9300, +1 (703) 527-3887
Icons in SDS
Company Information
company name
Eisai, Inc. (HQ)
e-mail address of the competent person responsible for the Safety Data Sheet
eisai_ehs@eisai.com
GHS Information
Signal word
Danger
Hazard Codes
Hazard statements (CLP)
H360D, H372
Hazard statements
Code
Statements
H360D
May damage the unborn child
Section 2
SECTION 2: Hazards identification
2.1 Classification of the substance or mixture
substance or mixture Globally Harmonized Specific Target Organ Toxicity (repeated exposure) - Category 1. Reproductive System [GHS] Toxicity - Category 1B. SECTION 2 - HAZARDS IDENTIFICATION …continued
Signal word
Danger
Hazard statements
H372 - Causes damage to kidney, bone, reproductive organs, gastrointestinal system, and adrenal system through prolonged or repeated exposure. H360D - May damage the unborn child. precautions have been read and understood. P260 - Do not breathe dust. P264 - Wash hands thoroughly after handling. P270 - Do not eat, drink or smoke when using this product. P308 + P313 - If exposed or concerned: get medical advice/ attention. P501 - Dispose of contents/container to location in accordance with local/ regional/national/international regulations. P280 - Wear protective gloves/eye protection/face protection.
Precautionary statements
P201 - Obtain special instructions before use. P202 - Do not handle until all safety
2.3 Other hazards
Lenvatinib is a potent kinase inhibitor that specifically blocks the activity of growth factors involved in blood vessel formation. In human clinical studies, adverse events reported have included fatigue, hypertension, proteinuria, and a range of gastrointestinal complaints. Note This substance is classified as hazardous under GHS as implemented by
