3.1.1 Chemical characterization (substance) Polydimethylsiloxane

Further information

Thermal decomposition...........................................: Decomposition begins at > 250 °C 10.1 – 10.3 Reactivity; Chemical stability; Possibility of hazardous reactions If stored and handled in accordance with standard industrial practices no hazardous reactions are known. Relevant information can possibly be found in other parts of thissection. 10.4 Conditions to avoid none known 10.5 Incompatible materials none known 10.6 Hazardous decomposition products If stored and handled properly: none known . Measurements have shown the formation of small amounts of formaldehyde at temperatures above about 150 °C (302 °F) through oxidation. 11.1 Information on toxicological effects 11.1.1 Acute toxicity Assessment: Based on the available data acute toxic effects are not expected after single oral exposure. Based on the available data acute toxic effects are not expected after single dermal exposure. Product details: Route of exposure Result/Effect Species/Test system Source oral LD50: > 5000 mg/kg rat Conclusion by analogy dermal LD50: > 2008 mg/kg rat Conclusion by analogy 11.1.2 Skin corrosion/irritation Assessment: Based on the available data a clinically relevant skin irritation hazard is not expected. Product details: 11.1.3 Serious eye damage / eye irritation Assessment: Based on the available data a clinically relevant eye irritation hazard is not expected. Product details: 11.1.4 Respiratory or skin sensitization Assessment: Based on the available data a sensitization reaction is not expected from this product. Product details: Route of exposure Result/Effect Species/Test system Source dermal not sensitizing guinea-pig; Magnusson-Kligmann Conclusion by analogy OECD 406 11.1.5 Germ cell mutagenicity Assessment: Based on known data a significant mutagenic potential may be excluded. Product details: Result/Effect Species/Test system Source negative mutation assay (in vitro) Conclusion by bacterial cells analogy OECD 471 11.1.6 Carcinogenicity Assessment: For this endpoint no toxicological test data is available for the whole product. 11.1.7 Reproductive toxicity Assessment: For this endpoint no toxicological test data is available for the whole product. 11.1.8 Specific target organ toxicity (single exposure) Assessment: For this endpoint no toxicological test data is available for the whole product. 11.1.9 Specific target organ toxicity (repeated exposure) Assessment: For this endpoint no toxicological test data is available for the whole product. 11.1.10 Aspiration hazard Assessment: For this endpoint no toxicological test data is available for the whole product. 11.1.11 Further toxicological information Human patch test: Product displays good compatibility with the skin. 12.1 Toxicity Assessment: Evaluation on basis of physical-chemical properties: No expected damaging effects to aquatic organisms. According to current knowledge adverse effects on water purification plants are not expected. 12.2