4553 THINNER

Health hazards

INFORMATION OVERVIEW: The most likely routes of worker exposure to the components of a vehicle or thinner product are skin contact and inhalation. Skin irritation and/or other effects of skin contact are easily avoided by: using proper gloves (See "Protection In-~- formation" section below); not touching exposed skin (like face, neck) or clothing with contaminated gloves; using pro- per techniques for removing gloves; washing affected areas immediately if skin contact securs; washing hands before leaving the work area. evaporate at room temperature when the product container is opened. Evaporation continues as the worker mixes this pro- duct by itself with a spatula, or uses it as a vehicle/thin- ner by mixing it into another DuPont paste product. Because (CONTINUED) 4553 PAGE 2 INFORMATION(continvuED) of the relatively low vapor pressure materials used in this product, rate of evaporation is expected to be very slow. However, concentration of volatile components may increase under other conditions. For example, printing very large substrate surfaces, or processing higher volumes of parts per unit time may increase the availability of volatile substances. Alse, during drying (90-150 deg C) most volatile solvents and organics will evaporate. Elevated temperatures cause more rapid generation of volatile components from the print- ed substrates. Consideration should also be given to over- exposure to other chemicals used in the operation, for exam- ple, solvents used to clean equipment is an another source of volatile substances. Local ventilation, "plumbed in" equipment ventilation and well designed enclosures around process equipment (like mix- ers, drying ovens, screen printers, etc) are effective ways to limit worker inhalation overexposure here necessary. Al- so, hand-mixing should be done with local ventilation or in a fume hood where fugitive vapors and volatile components would be kept out of the worker’s breathing zone. Personal protective equipment (e.g. cartridge respirator) also may be effective in reducing exposure if necessary. Well-designed area and personal air sampling and analysis can show if ex- posures are within required or recommended limits. Discharge from the ventilation systems should comply with all local, state and federal laws, regulations and permits. In addition to meeting exposure limits, significant differ ences in overall exposure can be made by practical steps: * Inhalation - minimize by keeping closed containers of products, solvents, cleaners, and solvent-dampened clean wipes; * Skin - avoid contact by wearing protective coverings, including gloves, and us- ing them properly; * Eyes ~ wear chemical safety glasses when handling the product, solvents, and waste materials, and where there is potential for splashing, wear chemi- cal goggles or face shield; * Ingestion - avoid by washing hands before eating, drinking or smoking and restricting PRINCIPAL HEALTH EFFECTS: >>>Terpineol (Mixed Isomers} ****Toxic effects described in animals include: BY SKIN OR EYE CONTACT: Skin irritation; Eye irritation; No skin sensitization. ****Additional animal tests have shown: BY INHALATION OF VAPORS OR FUMES FROM HEATED MATERIALS: No genetic damage in bacterial cell cultures; BY INGESTION: Developmental toxicity at dosage levels showing maternal toxicity.

Potential health effects

of overexposure may include: BY SKIN OR EYE CONTACT: Infrequently associated with skin sensitization in humans; Skin irritation with discomfort or rash; Eye irritation with discomfort, tearing, or blurring of vision; Allergic skin rashes; BY INHALATION: Irritation of the upper respiratory passages; BY INGESTION: (CONTINUED) 4553 PAGE 3 HEALTH HAZARD INFORMATION (continuep) Gastrointestinal tract irritation with upper abdominal pain (heartburn), nausea, vomiting and diarrhea; possibly "coffee grounds" vomitus and black, tarry stools from gastrointestinal bleeding; BY INHALATION OR INGESTION: Nonspecific discomfort, e.g., nausea, headache or weakness; Diarrhea. ****Human effects of higher level acute, repeated or chronic overexposure may include: BY INGESTION: Temporary nervous system depression with anaesthetic effects such as dizziness, headache, confusion, incoordination, loss of consciousness and possibly respiratory failure. ***In addition: BY INHALATION: One manufacturer of this low vapor pressure substance has recommended an EXPOSURE LIMIT of 100 parts per million (ppm) as a Time-Weighted Average (TWA) to protect workers against negative health effects that might be caused by this substance; BY INGESTION: Small amounts of this ingredient aspirated into the lungs during ingestion or vomiting may cause chemical pneumonia. Symptoms include coughing, gasping, choking, shortness of breath, bluish skin coloration, fever, rapid heart rate and breathing. Symptoms may be delayed up to 24 hours. >asDiethylene Glycol Dibutyl Ether ****Toxic effects described in animals include: BY SKIN CONTACT: Slight skin irritation; BY EYE CONTACT: Slight eye irritation. ****Additional animal tests have shown: No animal test reports are available to define carcinogenic, mutagenic, embrytoxic or reproductive hazards. of overexposure may include: BY SKIN CONTACT: May irritate skin; May be absorbed through skin; BY EYE CONTACT: May cause irritation; Burning sensation; BY INHALATION: Irritation of 4553/A01 Page 4 "glycol diethers" with similar chemical structure, in studies involving laboratory animals, have shown to cause reversible testicular and sperm damage as well as birth defects. Individuals may have increased susceptibility to

SECTION 2: Hazards identification

of overexposure to ingredient(s) of this product if they have pre- existing diseases of the: Central nervous system; Lungs. ANIMAL DATA: >>>Terpineol (Mixed Isomers) Inhalation (Aerosol) 4 hrs [Rats]: 3.70 mg/L Skin LDSO [Rabbits] >2.0 g/kg Oral LDSO [Rats]: >2.0 g/kg. >>>Diethylene Glycol Dibutyl Ether Inhalation LD50: no data found Skin Absorption LD50 [Rabbit]: 5040 mg/kg Oral Lb5u [Rac]: 3900 mg/kg. CARCINOGENICITY LISTING: (CONTINUED) ( PAGE 4 HEALTH HAZARD INFORMATION continuep) No ingredients of this product are designated by IARC, NTP,