"Vertrel" KCD-9561

Potential health effects

Gross overexposure by inhalation to HFC-43-10mee may cause suffocation if air is displaced by vapors and central nervous system stimulation with increased activity or sleeplessness, tremors or convulsions. These effects may be followed by central nervous system depression with dizziness, confusion, incoordination, drowsiness or unconsciousness. Based on data from other fluorocarbons, gross overexposure may be associated with irregular heartbeat or heart rhythm, which may produce heart palpitation, dizziness, weakness, unconsciousness and death. It is unlikely that concentrations sufficient to produce irregular heartbeat or heart rhythm would be achieved from HFC-43-10MEE without first producing other signs of toxicity. Immediate effects of overexposure to HFC-43-10mee by skin contact may include slight irritation with itching, redness or swelling. Repeated and/or prolonged exposure may cause defatting of the skin with itching, redness or rash. Based on animal data, significant skin permeation, and systemic toxicity after skin contact, appears unlikely. Immediate effects of overexposure to HFC-43-10mee by eye contact may include eye irritation with tearing, pain or blurred vision. The major ingestion hazard of HFC-43-10mee is aspiration (liquid entering the lungs during ingestion or vomiting) which may result in "chemical pneumonia." Symptoms include coughing, gasping, choking, shortness of breath, bluish discoloration of the skin, rapid breathing and heart rate, and fever. Pulmonary edema or bleeding, drowsiness, confusion, coma and seizures may occur in more serious cases. Symptoms may develop immediately or as late as 24 hours after exposure, depending on how much chemical entered the lungs. Increased susceptibility to the effects of HFC-43-10mee may be observed in persons with pre-existing disease of the central nervous system or the cardiovascular system. Short-term overexposure by inhalation to Nitromethane may cause irritation of the nose and throat with sneezing, sore throat or runny nose. Based on animal data repeated and/or prolonged exposure may cause irritation of nose, throat, and lungs with cough, difficulty breathing or shortness of breath, pathological changes in the liver, central nervous system depression with dizziness, confusion, incoordination, drowsiness or unconsciousness, peripheral nervous system effects with tingling, pain, or loss of sensation in extremities which may be accompanied by weakness or loss of muscle control, altered blood cell counts, impaired functioning of the blood-forming system with alterations in blood cell counts and/or anemia, effects on the nervous tissue, and clinical pathological changes of the thyroid. Skin contact with Nitromethane may cause skin irritation with itching, burning, redness, swelling or rash. Eye Continued) contact with Nitromethane may cause eye irritation with tearing, pain or blurred vision. Based on animal data, ingestion of Nitromethane may cause abnormal liver function with altered enzyme levels in blood, or abnormal kidney function with altered results on blood tests. # Carcinogenicity Information The following components are listed by IARC NTP