General Information
Version
2.1.0
Revision date
2018-06-15
Product name
Vasostrict
Product Synonyms
For vasopressin: 8-Arginine vasopressin; argipressin
Chemical name
Mixture - contains a synthetic peptide
CAS No.
113-79-1
1.2.1 Relevant identified uses
Bulk formulated pharmaceutical mixture/Formulated pharmaceutical product of the substance or packaged in final form for patient use; indicated to treat residual hypotension in mixture and uses adults with vasodilatory shock
Emergency telephone
+1 (800) 424-9300, +1 (703) 527-3887
Icons in SDS
Company Information
company name
drugsafety@parpharm.com
e-mail address of the competent person responsible for the Safety Data Sheet
drugsafety@parpharm.com
GHS Information
Signal word
None required
Section 2
SECTION 2: Hazards identification
WHMIS 2015 Classification of the substance or mixture Drugs in the finished state and intended for the final user are not subject to labeling in the US, EU or Canada. Please consult the prescribing/packaging information. The classification and labeling listed below is for bulk Vasopressin Injection Globally Harmonized System [GHS] Not classified HAZARDS IDENTIFICATION …continued
Hazard statements
None required None required
Signal word
None required
Precautionary statements
None required
2.3 Other hazards
Vasopressin is a potent antidiuretic and vasoconstricting agent. The most common adverse effects reported with use (up to ~100 µg/day) include marked pallor, pounding headache, vertigo, sweating, tremor, and gastrointestinal disturbances (nausea, vomiting, diarrhea, burping, cramps, and a desire to defecate). Women reported uterine cramps/contractions. A syndrome similar to water intoxication (characterized by listlessness, drowsiness, headache, and confusion, with subsequent seizures, coma, and death) has also been reported. Consistent with its activity, the drug may increase blood pressure, slow heart rate, and instigate other cardiovascular effects (e.g., heart block, minor arrhythmias, coronary insufficiency, and heart attack). Hypersensitivity reactions have also occurred. Based on its ability to cause uterine contractions and non-clinical study results described below, vasopressin may adversely affect pregnancy and/or a developing fetus. Note This substance does not meet criteria for classification under GHS as implemented
2.1 Classification of the substance or mixture
Drugs in the finished state and intended for the final user are not subject to substance or mixture
