Lorsban* 4E-SG Insecticide (NAF-163)

SECTION 2: Hazards identification

SYSTEMIC (OTHER TARGET ORGAN EFFECTS): EMERGENCY OVERVIEW Excessive exposure may produce organophosphate-type Hazardous chemical. Red liquid with solvent-type odor. cholinesterase inhibition. Signs and symptoms of excessive May cause eye irritation or corneal injury. Prolonged exposure to chlorpyrifos may be headache, dizziness, exposure may cause skin irritation. LD50 for skin incoordination, muscle twitching, tremors, nausea, absorption in rabbits is >5000 mg/kg. Oral LD50 for rats is abdominal cramps, diarrhea, sweating, pinpoint pupils, 776 mg/kg (males) and 300 mg/kg (females). LC50 for rats blurred vision, salivation, tearing, tightness in chest, is 2.7 mg/L for 4 hours. Cholinesterase inhibitor. Toxic to excessive urination, convulsions. Chlorpyrifos produced aquatic organisms, birds, and fish. mild adrenal effects when fed to rats, but only at doses that EMERGENCY PHONE NUMBER: 800-992-5994 greatly exceeded any exposures that would be received during normal use of this product. Solvent has been

Potential health effects

This section includes reported to cause liver, kidney, and blood effects at high possible adverse effects which could occur if this material exposure levels. Xylene is reported to have caused hearing is not handled in the recommended manner. loss in laboratory animals upon exposure to high concentrations; such effects have not been reported in EYE: May cause moderate eye irritation and/or corneal humans. For cumene, in animals, effects have been injury. Vapors may irritate the eyes. reported on the following organ: eye (cataract). *Trademark of Dow AgroSciences 1

Cancer information

Chlorpyrifos did not cause NOTE TO PHYSICIAN: Because rapid absorption may cancer in laboratory animals. Xylene was not found to be occur through the lungs if aspirated and cause systemic carcinogenic in a National Toxicology Program bioassay in effects, the decision of whether to induce vomiting or not rats and mice. should be made by a physician. If lavage is performed, suggest endotracheal and/or esophageal control. Danger TERATOLOGY (BIRTH DEFECTS): Chlorpyrifos did not from lung aspiration must be weighed against toxicity when cause birth defects in laboratory animals. Solvent was toxic considering emptying the stomach. If exposed, plasma and to the fetus in laboratory animal tests, but only at doses that red blood cell cholinesterase tests may indicate significance were toxic to the mothers. Very high concentrations of of exposure (baseline data are useful). Atropine, only by solvent (producing severe toxicity to adult animals) induced injection, is the preferable antidote. Oximes, such as 2- an increase in cleft palate in mice, which is a common PAM/protopam, may be therapeutic if used early; however, developmental abnormality in mice and is associated with use only in conjunction with atropine. In case of severe stress to the maternal animals. No malformations were acute poisoning, use antidote immediately after induced at exposures less than those causing severe establishing an open airway and respiration. Exposure may toxicity to the adult animals. This product contains low increase "myocardial irritability". Do not administer levels of xylene. Exaggerated doses of xylene given orally sympathomimetic drugs unless absolutely necessary. to pregnant mice resulted in an increase in cleft palate, a Supportive care. Treatment based on judgment of the common developmental abnormality in mice. Inhalation physician in response to reactions of the patient. exposure of pregnant animals to xylene resulted in toxicity to the fetus but did not cause any birth defects.