ALSAN RS 230 FLASH SUMMER / WINTER

Potential health effects

SKIN CONTACT MMA: Effects of Short-Term (Acute) Exposure MMA is probably a mild to moderate skin irritant, based on animal INHALATION information and limited human information. Mild redness was observed MMA: in approximately 16/50 volunteers, after a 48 hour exposure to cotton MMA is extremely volatile and can easily form high vapour saturated with MMA. MMA can be absorbed through the skin but no concentration at room temperatures. Low concentrations are probably harmful effects would be expected by this route of exposure. Repeated irritating to the nose, throat and respiratory tract. Higher concentrations or prolonged skin contact can cause allergic skin sensitization. (1) can probably cause symptoms of central nervous system (CNS) 2-EHA: depression, such as headache, nausea, dizziness, drowsiness, and 2-EHA is a severe irritant based on animal information. (1) confusion. Very high concentrations may cause loss of consciousness and possibly death. Due to its irritating nature, MMA may cause a Polyethylene glycol diacrylate: potentially fatal accumulation of fluid in the lungs. Symptoms may Suspect slight skin irritation hazard. Symptoms may include a slight include shortness of breath, pain in the chest and difficulty breathing. localized redness or rash and swelling. Although no appropriate human Symptoms may not develop for up to 24 hours after exposure. (1) or animal health effects data are known to exist, this material is expected to be a health hazard by skin absorption. (2) 2-EHA: 2-EHA is irritating to respiratory tract. (2) DPPT: Prolonged contact with the product can result in skin irritation. (2) Polyethylene glycol diacrylate: Suspect respiratory tract irritation hazard. Symptoms of irritation may EYE CONTACT include coughing, mucous production and shortness of breath. (2) MMA: MMA is probably a mild to moderate eye irritant, based on animal DPPT: information. (1) Irritating to the respiratory system. (2) 2-EHA: 2-EHA is a very mild irritant based on animal information. (1) Polyethylene glycol diacrylate: Polyethylene glycol diacrylate and DPPT: Suspect severe eye irritation hazard. Symptoms of irritation may No information available. include severe pain, tearing, redness or swelling. The damage to the eyes should be reversible. (2)

Teratogenic Effects

EMBRYOTOXICITY, FETOTOXICITY MMA: DPPT: There is no human information available. MMA has not caused Irritating to eyes and respiratory system. (2) teratogenic or embryotoxic effects in animals at exposures which were not maternally toxic. (1) INGESTION MMA: 2-EHA, Polyethylene glycol diacrylate and DPPT: Based on animal evidence, ingestion of MMA is likely to produce signs No information available. and symptoms of CNS depression. Ingestion is not a typical route of occupational exposure. (1) REPRODUCTIVE TOXICITY MMA: 2-EHA: No human information available. No effects have been observed in May be harmful if swallowed. (2) limited animal studies. (1) Polyethylene glycol diacrylate: 2-EHA, Polyethylene glycol diacrylate and DPPT: Suspect slight ingestion hazard. (2) No information available. DPPT: MUTAGENICITY Harmful if swallowed. (2) MMA: The available information does not indicate that MMA is mutagenic. Effects of Long-Term (Chronic) Exposure (1) SKIN SENSITIZATION 2-EHA: MMA: 2-eha demonstrated evidence of genotoxic activity in some assays (i.e. MMA is a skin sensitizer. There are numerous reports of allergic skin In vitro sister chromatid exchange, mouse lymphoma and in vitro sensitization developing in people occupationally exposed to products UDS), the activity was weak and equivocal. (2) containing MMA or MMA itself. These findings are supported by Polyethylene glycol diacrylate and DPPT: positive patch testing results. Once a person is sensitized to a material, No information available. contact with even a small amount causes outbreaks of dermatitis with symptoms such as skin redness, itching, rash and swelling. This can TOXICOLOGICALLY SYNERGISTIC MATERIALS spread from the hands or arms to other parts of the body. (1) MMA: No information available. (1) 2-EHA: 2-EHA is a skin sensitizer based on animal information. Sensitization 2-EHA, Polyethylene glycol diacrylate and DPPT: in humans has also been reported. Several case studies have reported No information available. dermatitis and hand eczema in workers exposed to 2-EHA in adhesives, POTENTIAL FOR ACCUMULATION glues, inks and other products. Positive patch test reactions were MMA: obtained for 2-EHA in many of these workers. (1) Probably does not accumulate. MMA is rapidly absorbed by the Polyethylene glycol diacrylate: inhalation, oral and dermal routes of exposure and distributed Suspect skin sensitization hazard. (2) throughout the body. It is metabolized to methanol and methacrylic acid, which is further metabolized and taken up in normal biochemical DPPT: pathways in the body. Elimination is mainly by exhalation of carbon Skin sensitizing effects were not observed in animal studies. (2) dioxide. (1) NERVOUS SYSTEM 2-EHA, Polyethylene glycol diacrylate and DPPT: MMA: No information available. Based on human studies and supported by animal evidence, long-term exposure to MMA can probably cause mild central nervous system RESPIRATORY SENSITIZATION effects (e.g. headache, nausea, dizziness). (1) MMA: There is insufficient information available to conclude that MMA is a 2-EHA, Polyethylene glycol diacrylate and DPPT: respiratory sensitizer. There are only three reliable case reports of No information available. respiratory sensitization developing after occupational exposure to CARCINOGENICITY products containing MMA. This is a very small number of cases MMA: compared to the total population exposed to MMA in the workplace. In general, human studies have not shown convincing evidence of an Sensitized people can experience symptoms of bronchial asthma such increased cancer risk from exposure to MMA. One study showed as wheezing, difficult breathing, sneezing and runny or blocked nose at increased colorectal cancer in a three groups exposed to MMA and low airborne concentrations that have no effect on unsensitized people. ethyl acrylate and their volatile by-products. No conclusions can be 2-EHA, Polyethylene glycol diacrylate and DPPT: drawn from this study due limitations such as the concurrent exposures. No information available. Negative results have been obtained in animal studies. The International Agency for Research on Cancer (IARC) has concluded that this chemical is not classifiable as to its carcinogenicity to humans SECTION IV: FIRST AID MEASURES (Group 3). The American Conference of Governmental Industrial SKIN CONTACT Hygienists (ACGIH) has designated this chemical as not classifiable as Avoid exposition to direct sunlight or UV rays while the product is on a human carcinogen (A4). The US National Toxicology Program the skin. Remove contaminated clothing. Wash thoroughly with soap (NTP) has not listed this chemical in its report on carcinogens. (1) and water. Do not use solvents. If irritation persists, get immediate 2-EHA: medical attention. The International Agency for Research on Cancer (IARC) has EYE CONTACT concluded that this chemical is not classifiable as to its carcinogenicity Avoid exposition to direct sunlight or UV rays while the product is on to humans (Group 3). the eyes. Flush thoroughly with water for at least 15 minutes. If irritation persists, get immediate medical attention. INHALATION static accumulation. Tightly reseal all partially used containers. Do not In case of gas or vapour inhalation, move victim to fresh air. If cut, puncture or weld containers. breathing is difficult, give oxygen. If breathing stops, give respiratory assistance. Obtain immediate medical attention.