Aflatoxin B1 ELISA TEST KIT

SECTION 2: Hazards identification

Warnings Toxic if swallowed. Irritates eyes, respiratory tract and skin. In case of breathing in or skin contact, a sensitisation may be possible. Because of a possible mutagenic effect, an irreversible defect is possible (affected organs are kidneys and CNS). In case of contact with acids, the development of toxic gases is possible. 3.3 First Aid Measures Eye Contact Promptly wash eyes with water for at least 15 minutes. Seek medical advice. Skin Contact Flush skin with copious amounts of water and soap. Ingestion Wash out mouth with water provided person is conscious. Seek medical advice Inhalation Remove to fresh air. If breathing becomes difficult, seek medical advice. Changing Clothes In case of sever contamination. 3.4 Fire-Fighting Measures Extinguishing Media Water spray. Use carbon dioxide, dry chemical powder or appropriate foam. Special Fire Fighting Procedure Wear self-containing breathing apparatus and special protective clothes. Unusual Fire Fighting Procedure N/A Thermal Decomposition Emits toxic fumes under fire conditions. 3.5 Accidental Release Measures Personal Protection Protective glasses, rubber gloves and protective clothing. Steps after Spillage Remove spilled fluid onto an inert material. Ventilate area. Wash area with soap solution. Collect contaminated fluid and material in a special closable container. Absorbent materials No restriction. Waste Disposal Method Consult a specialist for disposal or the spilled substance. 3.6 Handling and Storage DAI Code # 8 2 Handling Wear protective clothing. Avoid contact with eyes, skin and clothes. Open and handle container carefully. Thoroughly washing after use is recommended.

Storage

Store between +2°C and +8°C. 3.7 Exposure Controls / Personal Protection TLV No. Personal Protection Protective glasses, rubber gloves and clothing. Thoroughly washing after use is recommended 3.8 Physical and Chemical Properties Physical State Liquid Flash Point N/A Color Red Ignition Temperature N/A Odor N/A Explosion Limits N/A pH-Value 6.2-6.7 Vapor Pressure N/A Boiling Point 100 °C Solubility in Water Complete Melting Point N/A Viscosity N/A 3.9 Stability and Reactivity Hazardous Decomposition Products Mercury Hazardous Polymerization Will not occur 3.10 Toxicological Information LD50 Oral (rat) 18 mg/kg LD50 Skin (rat) 75 mg/kg LD50 Oral (man) 357 mg/mg LD50 Inhalation Not Known 3.11 Ecological Information Water Hazard Class 1 (own specification) 4. Standards 4.1 Chemical Characterization / Information on Ingredients Character Methanol CAS-No. 67-56-1 EINECS-No. 200-659-6 Keep container closed. Keep away from heat, sparks and open flame 4.7 Exposure Controls / Personal Protection Engineering Controls Safety shower and eye bath. Use non-sparking tools. Use only in a chemical fume hood. Personal Protection Protective glasses, rubber gloves and clothing. Thoroughly washing after use is recommended 4.8 Physical and Chemical Properties Physical State Liquid Autoignition Temperature 385°C Color Colorless Explosion Limits Lower: 6% Vapor Pressure 97.68 mmHg Upper: 36% pH-Value N/A Solubility in Water Miscible Boiling Point 64-65 °C Solubility in……. N/A DAI Code # 8 4 Melting Point -98°C Viscosity N/A Flash Point 11°C 4.9 Stability and Reactivity Hazardous Reactions Stable. Avoid acids, acid chlorides, acid anhydrides, oxidizing agents, alkali metals, reducing agents. Hazardous Decomposition Products Carbon monoxide, carbon dioxide. Hazardous Polymerization Will not occur 4.10 Toxicological Information LD50 Oral (rat) 5628 mg/kg LD50 Skin (rabbit) 15800 mg/kg LD50 Oral (man) 6422 mg/kg LD50 Inhalation (rat) 640000 ppm Signs and Symptoms of exposure Methyl alcohol may be fatal or cause blindness if swallowed. Cannot be made non-poisonsous. Ingestion can cause: nausea, headache and vomiting. Gastrointestinal disturbances. Dizziness. Weakness. Confusion. Drowsiness. Unconsciousness. May cause convulsions. Store between +2°C and +8°C. 5.7 Exposure Controls / Personal Protection Personal Protection Protective glasses, rubber gloves and clothing. Thoroughly washing after use is recommended. 5.8 Physical and Chemical Properties Physical State Liquid Flash Point N/A Color Colorless Explosion Limits N/A Odor N/A Vapor Pressure N/A pH-Value 7.0-7.5 Solubility in Water complete Boiling Point 100°C Ignition Temperature N/A Melting Point -N/A Viscosity N/A 5.9 Stability and Reactivity Stability Stable at normal temperatures and pressures Incompatibility May react with strong oxidizing agents (e.g. peroxides, permanganates, nitric acid etc.) Hazardous Decomposition Products May emit toxic mercury fumes when heated to decomposition. Hazardous Polymerization Will not occur 5.10 Toxicological Information Acute exposure Oral Rat, median lethal dose 73 mg/kg, reduced activity, drooping eyelids, weakness. Skin No applicable information found. Inhalation No applicable information found. Intravenous Rat, median lethal dose estimated greater than 45 mg/kg, mortality. Skin Contact Rabbit, nonirratant. Eye Contact Rabbit irritant. Chronic exposure Target organ effects Kidney effects (tubule necrosis), lung effects (tissue changes). Other effects Decreased weight gain. Reproduction Decreased offspring survival. Sensitization No applicable information found. Mutagenicity Mutagenic in mammalian cells. Not mutagenic in bacterial cells. DAI Code # 8 7 5.11 Ecological Information Water Hazard Class 1 (own specification) 6. Conjugate

2.1 Classification of the substance or mixture

Highly flammable, Toxic Warnings Highly flammable. Toxic by inhalation, in contact with skin, and if swallowed. 4.3 First Aid Measures DAI Code # 8 3 Eye Contact In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician. Skin Contact In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician. Ingestion If swallowed, wash mouth with water provides person is conscious. Call a physician immediately. Inhalation If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen. 4.4 Fire-Fighting Measures Extinguishing Media Water spray. Use carbon dioxide, dry chemical powder or appropriate foam. Special Fire Fighting Procedure Wear self-contained breathing apparatus and special protective clothes to prevent contact with skin and eyes. Special risks Specific hazards: Flammable liquid. Emits toxic fumes under fire conditions. Explosion hazards: Vapor may travel considerable distance to source of ignition and flash back. Container explosion may occur under fire conditions 4.5 Accidental Release Measures Personal Protection Wear self-contained breathing apparatus, rubber boots and heavy rubber gloves. Steps after Spillage Evacuate area. Shut off all sources of ignition. Environmental Precaution Do not allow material to enter drains or water courses Methods for cleaning up Cover with dry-lime, sand or soda ash. Place in covered containers using non-sparking tools and transport outdoors. Ventilate area and wash spill site after material pickup is complete. 4.6 Handling and Storage Handling Do not breathe vapour. Avoid contact with eyes, skin and clothing. Avoid prolonged or repeated exposure.

Principle Routes of Exposure

Causes skin irritation. Toxic if adsorbed through skin. Causes eye irritation. Toxic if inhaled. Material may be irritating to mucous membranes and upper respiratory tract. Toxic if swallowed. Target Organ Information Eyes. Kidneys. Liver. Heart. Central Nervous System. 4.11 Ecological Information Test Type LC50 Fish Species Onchorhynchus mykiss (Rainbow trout) Time 96 h value 19000 mg/L Test Type LC50 Fish Species Cyprinus carpio Time 48h value 36000mg/L Test Type EC50 Daphnia Species Daphnia magna Time 48h value 24500 mg/L Test Type EC50 Daphnia Species Daphnia magna Time 24h value 10000 mg/L 5. Standard / Sample Diluent 5.1 Chemical Characterization / Information on Ingredients Character Product contains 0.02 % Thimerosal (Merthiolate, C9H9HgNaO2S) DAI Code # 8 5 CAS-No. 54-64-8 EINECS-No. 200-210-4 EC Index No. 080-004-00-7

Classifications

Toxic, irritant, possibly mutagenic. Warnings Thimerosal may enter the body through the skin, is toxic, alters genetic material, may be irritating to the eyes and causes allergic reactions. Effects of exposure may include numbness of extremities, fetal changes, decreased offspring survival and lung tissue changes Routes if entry: Inhalation and skin absorption Effects of overexposure: Topical allergic dermatitis has been reported. Thimerosal contains mercury. Mercury poisoning may occur and topical hypersensitivity reactions may be seen. Early signs of mercury poisoning in adults are nervous system effects, including narrowing of the visual field and numbness in the extremities. Exposure of mercury in utero and in children may cause mild to severe mental retardation and mild to severe motor coordination impairment. Based on animal data, may be irritating to the eyes 5.3 First Aid Measures Eye Contact Hold eyelids open and flush with a steady, gentle stream of water for 15 minutes. Seek medical advice. Skin Contact Thimerosal is intended for topical application to the skin. However in case of unintentional exposure, especially of large areas of skin, wash with soap and water. If symptoms develop seek medical advice. Ingestion Call a physician or poison control centre. Drink one or two glasses of water and give 1-2 tablespoons syrup of ipecac to induce vomiting. Do not induce vomiting or give anything by mouth to an unconscious person. Use of chelating agents such as BAL may be needed to treat ingestion of mercury. Immediately transport to a medical care facility and see a physician. Inhalation Remove to fresh air. If breathing becomes difficult, seek medical advice. If not breathing, provide artificial respiration assistance (mouth-to- mouth) and call a physician immediately. Changing Clothes In case of sever contamination 5.4 Fire-Fighting Measures Extinguishing Media Water spray. Use carbon dioxide, dry chemical powder or appropriate foam. Special Fire Fighting Procedure Wear self-containing breathing apparatus and special protective clothes. Unusual Fire Procedure Thimerosal as pure substance may form dust mixtures in air which could explode in subjected to an ignition source. Thermal decomposition Emits toxic mercury fumes when heated to decomposition. 5.5 Accidental Release Measures DAI Code # 8 6 Spills Wear protective equipment, including eye protection, to avoid exposure. Vacuum material with appropriate dust collection filter in place. Be aware or potential of dust explosion when using electrical equipment. If vacuum is not available, lightly mist material and remove by sweeping or wet wiping. 5.6 Handling and Storage Handling Wear protective clothing. Avoid contact with eyes, skin and clothes. Open and handle container carefully. Thoroughly washing after use is recommended.