dsDNA Test Kit

Most important adverse effects

The human serum components used in the preparation of the Controls and Calibrator in this kit have been tested by an FDA approved method for the presence of antibodies to human immunodeficiency virus 1 & 2 (HIV 1&2), hepatitis C (HCV) as well as hepatitis B surface antigen and found negative. Because no test method can offer complete assurance that HIV, HCV, hepatitis B virus, or other infectious agents are absent, specimens and human-based reagents should be handled as if capable of transmitting infectious agents. LABEL PRECAUTIONARY STATEMENTS Stop Solution Product Code Xi Irritant FOR SULFURIC ACID IN STOP SOLUTION PREPARATION: DANGER! CORROSIVE LIQUID AND MIST CAUSE SEVERE BURN TO ALL BODY TISSUE. MAY BE FATAL IF SWALLOWED OR CONTACTED WITH SKIN. HARMFUL IF INHALED. AFFECTS TEETH. CANCER HAZARD. STRONG INORGANIC ACID MISTS CONTAINING SULPHURIC ACID CAN CAUSE CANCER. RISK OF CANCER DEPENDS ON DURATION AND LEVEL OF EXPOSURE. WEAR SUITABLE CLOTHING. IN CASE OF ACCIDENT OR IF YOU FEEL UNWELL, SEEK MEDICAL ADVICE IMMEDIATELY (SHOW THE LABEL WHERE POSSIBLE).

Potential health effects

The following general hazard warnings apply to all the kit components Potential Routes of Exposure: Target organs: Skin Contact, eye contact, accidental ingestion, inhalation Eye: Excessive contact may cause eye irritation, redness, pain, burns Sulfuric Acid: Corrosive. Effects should be less severe than from exposure to higher concentrations of sulphuric acid. Symptoms may include blurred vision, redness, pain, and burns to eye tissue. Skin: Direct or repeated contact may cause skin irritation. May be absorbed through the skin causing systemic effects (see effects for inhalation and ingestion). Dermatitis Sulfuric Acid: Corrosive. Effects should be less severe than from exposure to higher concentrations of sulphuric acid. Symptoms may include redness, pain, and burns to the skin. Circulatory collapse with clammy skin, weak and rapid pulse, shallow respirations, and scanty urine may follow ingestion or skin contact. Inhalation: Do not breathe vapor. Sulfuric Acid: Corrosive. Effects should be less severe than from exposure to higher concentrations of sulphuric acid. Symptoms may include irritation of the nose and throat, labored breathing, as well as lung edema, damage to the mucous membranes and upper respiratory tract. Accidental ingestion: General –Abdominal pain. Shortness of breath. Unconsciousness. Vomiting. Sweating. Drowsiness. Sulfuric Acid: Corrosive. Effects should be less severe than from exposure to higher concentrations of sulphuric acid. Symptoms may include severe burns of the mouth, throat, and stomach. Circulatory collapse with clammy skin, weak and rapid pulse, shallow respirations, and scanty urine may follow ingestion or skin contact. Circulatory shock is often the immediate cause of death. May cause sore throat, vomiting, diarrhea. Chronic Toxicity Prolonged or repeated contact may cause allergic dermatitis (redness, irritation, rash), may cause sensitization. Sulfuric Acid: Long term exposure to mist or vapors may cause damage to teeth. Chronic exposure to mists containing sulphuric acid is a cancer hazard. Reproductive and Developmental Toxicity: None identified. Carcinogenicity: None identified for DMSO. Carcinogenicity applies to “strong inorganic acid mists containing sulfuric acid” but not to sulfuric acid or sulfuric acid solutions.

Medical Conditions Generally Aggravated by Exposure

DMSO: Eye Disorders, Skin disorders, Liver or Kidney disorders. Topical application enhances dermal absorption of many other chemicals, including drugs/allergens of moderate molecular weight. Sulfuric Acid: Pre-existing skin disorders, eye problems, respiratory function may be more Susceptible to the effects of the substance.

Environmental effects

See section 12 – Ecological Information EC classification of the preparation: TMB Substrate solution containing DMSO and Sulfuric acid are classified as irritants. As only a minimal amount of the preparation is provided with the TMB substrate and Stop Solution, container and packaging are not marked with the irritant symbol. Warnings are provided in the package insert with regards to the use of this product and it is recommended that protective clothing be worn.