Naziv Proizvoda

SECTION 2: Hazards identification

1272/2008 Specific M-Factor registration Index No) according to concentration (long-term) number Regulation limit (SCL) (EC) No.

Hazard statements

see section 16 Acute Toxicity Estimate No information available Chemical name Oral LD50 mg/kg Dermal LD50 mg/kg Inhalation LC50 - 4 Inhalation LC50 - 4 Inhalation LC50 - 4 hour - dust/mist - hour - vapor - mg/L hour - gas - ppm mg/L HEPES 2000 No data available 7365-45-9 This product does not contain candidate substances of very high concern at a concentration >=0.1% (Regulation (EC) No.

Storage

Conditions Keep container tightly closed in a dry and well-ventilated place. 7.3. Specific end use(s) Metode upravljanja rizikom (RMM) Zahtevane informacije sadržane su u ovom bezbednosnom listu. SECTION 8: Exposure controls/personal protection 8.1. Control parameters Exposure Limits This product, as supplied, does not contain any hazardous materials with occupational exposure limits established by the region specific regulatory bodies. Biological occupational exposure This product, as supplied, does not contain any hazardous materials with biological limits limits established by the region specific regulatory bodies. Derived No Effect Level (DNEL) - Workers No information available Derived No Effect Level (DNEL) - General Public No information available. Predicted No Effect Concentration (PNEC) No information available. 8.2. Exposure controls Engineering controls No information available. Oprema za ličnu zaštitu Eye/face protection Appropriate eye/face protection should be selected and used according to the chemical nature, hazards and use of this product and safety requirements of the local jurisdiction. Hand protection Appropriate hand protection should be selected and used according to the chemical nature, hazards and use of this product and safety requirements of the local jurisdiction. Skin and body protection Appropriate skin and body protection should be selected and used according to the chemical nature, hazards and use of this product and safety requirements of the local jurisdiction. Respiratory protection Appropriate respiratory protection should be selected and used according to the chemical nature, hazards and use of this product and safety requirements of the local jurisdiction. If exposure limits are exceeded or irritation is experienced, ventilation and evacuation may be required. General hygiene considerations Handle in accordance with good industrial hygiene and safety practice. Environmental exposure controls No information available. POGLAVLJE 9: Fizička i hemijska svojstva 9.1. Information on basic physical and chemical properties Physical state Solid Izgled Lyophilized Boja Off-white to white Miris Nema dostupnih informacija. Prag mirisa Nema dostupnih informacija Property Values

Remarks

Method Melting point / freezing point No data available Nema poznatih Initial boiling point and boiling No data available Nema poznatih range Zapaljivost No data available Nema poznatih Flammability Limit in Air Nema poznatih Upper flammability or explosive No data available limits Lower flammability or explosive No data available limits Tačka paljenja No data available Nema poznatih Temperatura samopaljenja No data available Nema poznatih Temperatura razlaganja Nema poznatih pH No data available Nije primenljivo pH (kao vodeni rastvor) No data available None known Kinematička viskoznost No data available Nema poznatih Dinamički viskozitet No data available Nema poznatih Water solubility No data available Nema poznatih Rastvorljivost(i) No data available Nema poznatih Koeficijent raspodele No data available Nema poznatih Pritisak pare No data available Nema poznatih Relativna gustina No data available Nije primenljivo Gustina na veliko No data available Liquid Density nema dostupnih podataka Relative vapor density No data available Nema poznatih Particle characteristics Particle Size Nema dostupnih informacija Particle Size Distribution Nema dostupnih informacija

Further information

9.2.1. Information with regard to physical hazard classes Nije primenljivo 9.2.2. Other safety characteristics Nema dostupnih informacija POGLAVLJE 10: Stabilnost i reaktivnost 10.1. Reactivity Reactivity No information available. 10.2. Chemical stability Stability Stable under normal conditions. Podaci o eksploziji Sensitivity to mechanical impact None. Sensitivity to static discharge None. 10.3. Possibility of hazardous reactions Possibility of hazardous reactions None under normal processing. 10.4. Conditions to avoid Conditions to avoid None known based on information supplied. 10.5. Incompatible materials Incompatible materials None known based on information supplied. 10.6. Hazardous decomposition products Hazardous decomposition products Nema poznatih osnova za date informacije. POGLAVLJE 11: Toksikološki podaci 11.1. Information on hazard classes as defined in Regulation (EC) No 1272/2008 Information on likely routes of exposure Product Information Inhalation Specific test data for the substance or mixture is not available. Eye contact Specific test data for the substance or mixture is not available. Skin contact Specific test data for the substance or mixture is not available. Ingestion Specific test data for the substance or mixture is not available. Symptoms related to the physical, chemical and toxicological characteristics Symptoms No information available. Acute toxicity Numerical measures of toxicity No information available The following values are calculated based on chapter 3.1 of the GHS document ATEmix (oral) 7,369.00 mg/kg ATEmix (dermal) 7,369.00 mg/kg 0 % of the mixture consists of ingredient(s) of unknown acute oral toxicity. 0 % of the mixture consists of ingredient(s) of unknown acute dermal toxicity. 0 % of the mixture consists of ingredient(s) of unknown acute inhalation toxicity (gas). 0 % of the mixture consists of ingredient(s) of unknown acute inhalation toxicity (vapor). 0 % of the mixture consists of ingredient(s) of unknown acute inhalation toxicity (dust/mist). Chemical name Oral LD50 Dermal LD50 Inhalation LC50 HEPES > 2000 mg/kg ( Rat ) - Odloženi i neposredni efekti,kao i hronični efekti od kratkotrajnog i dugotrajnog izlaganja Skin corrosion/irritation No information available. Serious eye damage/eye irritation No information available. Respiratory or skin sensitization No information available. Germ cell mutagenicity No information available. Carcinogenicity No information available. Reproductive toxicity No information available. STOT - single exposure No information available. STOT - repeated exposure No information available. Aspiration hazard No information available. 11.2. Information on other hazards 11.2.1. Endocrine disrupting properties Endocrine disrupting properties No information available. 11.2.2. Other information Ostali štetni efekti Nema dostupnih informacija. POGLAVLJE 12: Ekotoksikološki podaci 12.1. Toxicity Ecotoxicity The environmental impact of this product has not been fully investigated. Unknown aquatic toxicity Contains 72.86 % of components with unknown hazards to the aquatic environment. Chemical name Algae/aquatic plants Fish Toxicity to Crustacea microorganisms HEPES - LC50: >100mg/L (96h, - Danio rerio) 12.2. Persistence and degradability Perzistentnost i razgradljivost Nema dostupnih informacija. 12.3. Bioaccumulative potential Bioaccumulation There is no data for this product. Chemical name Partition coefficient HEPES <-3.85 12.4. Mobility in soil Mobilnost u zemljištu Nema dostupnih informacija. 12.5. Results of PBT and vPvB assessment PBT and vPvB assessment The product does not contain any substance(s) classified as PBT or vPvB above the threshold of declaration. Chemical name PBT and vPvB assessment HEPES The substance is not PBT / vPvB 12.6. Endocrine disrupting properties Endocrine disrupting properties No information available. 12.7. Other adverse effects Nema dostupnih informacija. SECTION 13: Disposal considerations 13.1. Waste treatment methods Waste from residues/unused Dispose of in accordance with local regulations. Dispose of waste in accordance with products environmental legislation. Contaminated packaging Do not reuse empty containers. POGLAVLJE 14: Podaci o transportu IATA (Međunarodna asocijacija za vazdušni transport) 14.1 UN number or ID number Not regulated 14.2 14.3 Transport hazard class(es) Not regulated 14.4 Grupa pakovanja Nije regulisano 14.5 Opasnosti po životnu sredinu Nije primenljivo 14.6 Special precautions for user Specijalne Odredbe Nijedno IMDG (Pomorski prevoz opasne robe) 14.1 UN number or ID number Not regulated 14.2 14.3 Transport hazard class(es) Nije regulisano 14.4 Grupa pakovanja Nije regulisano 14.5 Opasnosti po životnu sredinu Nije primenljivo 14.6 Special precautions for user Specijalne Odredbe Nijedno 14.7 Maritime transport in bulk Nema dostupnih informacija according to IMO instruments RID 14.1 UN number or ID number Nije regulisano 14.2 14.3 Transport hazard class(es) Nije regulisano 14.4 Grupa pakovanja Nije regulisano 14.5 Opasnosti po životnu sredinu Nije primenljivo 14.6 Special precautions for user Specijalne Odredbe Nijedno ADR 14.1 UN number or ID number Nije regulisano 14.2 14.3 Transport hazard class(es) Nije regulisano 14.4 Grupa pakovanja Nije regulisano 14.5 Opasnosti po životnu sredinu Nije primenljivo 14.6 Special precautions for user Specijalne Odredbe Nijedno POGLAVLJE 15: Regulatorni podaci 15.1. Safety, health and environmental regulations/legislation specific for the substance or mixture Evropska unija Take note of Directive 98/24/EC on the protection of the health and safety of workers from the risks related to chemical agents at work. Authorizations and/or restrictions on use: This product does not contain substances subject to authorization (Regulation (EC) No. 1907/2006 (REACH), Annex XIV) This product does not contain substances subject to restriction (Regulation (EC) No. 1907/2006 (REACH), Annex XVII) Persistent Organic Pollutants Not applicable Ozone-depleting substances (ODS) regulation (EC) 1005/2009 Not applicable Međunarodni inventari TSCA (Zakon o kontroli toksičnih Contact supplier for inventory compliance status supstanci) DSL/NDSL Contact supplier for inventory compliance status EINECS/ELINCS Contact supplier for inventory compliance status ENCS Contact supplier for inventory compliance status IECSC Regulisano KECL Contact supplier for inventory compliance status PICCS Contact supplier for inventory compliance status AIIC Contact supplier for inventory compliance status NZIoC Contact supplier for inventory compliance status Legenda: TSCA - Poglavlje 8(b) Inventar Akta o Kontroli Toksičnih Supstanci Sjedinjenih Država DSL/NDSL - Kanadska Lista Kućnih Supstanci/Supstanci Koje Nisu Kućne EINECS/ELINCS - Evropski inventar postojećih hemijskih supstanci/ Evropska lista notifikovanih hemijskih supstanci ENCS - Japanske Postojeće i Nove Hemijske Supstance IECSC - Kineski Inventar Postojećih Hemijskih Supstanci KECL - Korejske Postojeće i Procenjene Hemijske Supstance PICCS - Filipinski Inventar Hemikalija i Hemijskih Supstanci AICS - Australijski Inventar Hemijskih Supstanci (Australian Inventory of Chemical Substances) NZIoC - Novozelandski Inventar Hemikalija 15.2. Chemical safety assessment Izveštaj o Hemijskoj Bezbednosti Nema dostupnih informacija POGLAVLJE 16: Ostali podaci Ključ ili legenda skraćenica i akronima korišćenih u listu sa bezbednosnim podacima Legenda SVHC: Substances of Very High Concern for Authorization: PBT: Persistent, Bioaccumulative, and Toxic (PBT) Substances vPvB: Very Persistent and very Bioaccumulative (vPvB) Substances STOT: Specific Target Organ Toxicity ATE: Acute Toxicity Estimate LC50: 50% Lethal Concentration LD50: 50% Lethal Dose Legenda Section 8: EXPOSURE CONTROLS/PERSONAL PROTECTION TWA (prosečna TWA (prosečna koncentracija uzoraka u STEL (granica STEL (granica kratkotrajne izloženosti) koncentracija jedinici vremena) kratkotrajne uzoraka u jedinici izloženosti) vremena) Gornji limit Maksimalna granična vrednost Sk* Oznaka kože + Senzibilizirajuća sredstva Procedura klasifikacije Klasifikacija na osnovu propisa (EC) br. 1272/2008 [CLP] Korišćen Metod Acute oral toxicity Metoda izračunavanja