TECTYL 2473 D&B GRAY

SECTION 2: Hazards identification

Eye: Can cause eye irritation. Symptoms include stinging, tearing, redness, and swelling of eyes. Skin: Can cause skin irritation. Prolonged or repeated contact may dry the skin. Symptoms may include redness, burning, and drying and cracking of skin, burns and other skin damage. Passage of this material into the body through the skin is possible, and may add to toxic effects from breathing or swallowing. Swallowing: Swallowing small amounts of this material during normal handling is not likely to cause harmful effects; Swallowing large amounts may be harmful. Inhalation: Breathing of vapor or mist is possible. Symptoms of Exposure: stomach or intestinal upset (nausea, vomiting, diarrhea) irritation (nose, throat, airways). Target Organ Effects: Reduced body weights as well as spleen and sex organ changes were observed following repeated inhalation (4 weeks) of butyl benzyl phthalate by rats. Lower concentrations for a longer period (3 months) produced increased liver and kidney weights. Following repeated exposures (up to 26 weeks) to this material in their feed, reduced body weights and food consumption, weakness, hind limb stiffness, some organ weight changes and effects on liver, testes and pancreas were observed in rats. There was no evidence of changes in nervous system tissues including delayed effects in chickens (repeat oral doses) or rats (single and repeat oral doses) . Overexposure to this material (or its components) has been suggested as a cause of the following effects in laboratory animals, and may aggravate preexisting disorders of these organs in humans: blood abnormalities, liver abnormalities, anemia, spleen damage, testis damage, eye damage, kidney damage, lung damage. Developmental Information: This material (or a component) has been shown to cause harm to the fetus in laboratory animal studies. Harm to the fetus occurs only at exposure levels that harm the pregnant animal. The relevance of these findings to humans is uncertain. Butyl benzyl phthalate did not produce birth defects in rabbits given this material orally during pregnancy at doses that did not produce maternal toxicity. However, another study reports birth defects in mice and rats given butyl benzyl phthalate orally during pregnancy but only at doses which produced significant toxic effects in the mothers and the offspring. Testicular changes and reduced fertility were reported in male rats fed high doses of butyl benzyl phthalate for 3 weeks or longer.

Cancer information

Carbon Black has been classified by IARC as a Category 2B (known animal carcinogen, possible human carcinogen) material. This was based on the results of rat inhalation studies of carbon black, despite the lack of parallel evidence on humans or other animal species. Female rats fed butyl benzyl phthalate in long-term (2 year) studies conducted by the National Toxicology Program (NTP) were reported to show an increased frequency of mononuclear cell leukemia, a common spontaneous disease in the test strain of rat. For this reason, NTP concluded that butyl benzyl phthalate was “probably carcinogenic” for these rats. Male rats in these studies were terminated after 6 months due to excessive treatment related deaths. Mice fed butyl benzyl phthalate (2 years) had no increase in tumors. Butyl benzyl phthalate has produced no genetic changes in standard tests using animal, bacterial and yeast cells.

Other Health Effects

No data

Principle Routes of Exposure

Inhalation, Skin absorption, Skin contact, Eye contact