REVERTOR 5MG/ML 10ML VFR

SECTION 2: Hazards identification

Most important adverse effects

Only hazardous if applied / ingested to humans in error, may cause severe blood pressure decrease. Specific hazards Due to the potent pharmacological activity of atipamezole, skin—, eye- and mucous membrane- contact with this product should be avoided. In case of accidental spillage wash the affected area immediately with clean running water. Seek medical attention if irritation persists. Remove contaminated clothes that are in direct contact with the skin. Care should be taken to avoid accidental ingestion or self-injection. If accidental ingestion or self-injection occurs, seek medical attention immediately, showing a copy of the package leaflet. Atipamezole is a potent and selective a2-receptor blocking agent (a@2-antagonist), which promotes the release of the neurotransmitter noradrenaline in the central as well as in the peripheral nervous systems. This leads to activation of the central nervous system due to sympathetic activation. Other pharmacodynamic effects as for example influence of the cardiovascular system are only mild — but a transient decrease of blood pressure may be seen within the first 10 minutes after injection of atipamezole hydrochloride. As a a2-antagonist, atipamezole is capable of eliminating (or inhibiting) the effects of the a2-receptor agonist, medetomidine or dexmedetomidine. Thus atipamezole reverses the sedative effects of medetomidine hydrochloride in dogs to normal and may lead to a transient increase in heart rate..