PPS 82

SECTION 2: Hazards identification

Emergency Overview Appearance: liquid WARNING! FLAMMABLE LIQUID AND VAPOR. MAY AFFECT THE CENTRAL NERVOUS SYSTEM CAUSING DIZZINESS, HEADACHE OR NAUSEA. MAY BE HARMFUL IF INHALED. MAY CAUSE EYE, SKIN AND RESPIRATORY TRACT IRRITATION. PROLONGED OR REPEATED CONTACT MAY DRY SKIN, CAUSE IRRITATION AND BURNS.

Principle Routes of Exposure

Inhalation, Skin absorption, Skin contact, Eye Contact, Ingestion Eye contact Can cause eye irritation. Symptoms include stinging, tearing, redness, and swelling of eyes. Additional symptoms of eye exposure may include: blurred vision Skin contact Can cause skin irritation. Prolonged or repeated contact may dry the skin. Symptoms may include redness, burning, and drying and cracking of skin, burns and other skin damage. Additional symptoms of skin contact may include: skin blistering Passage of this material into the body through the skin is possible, but it is unlikely that this would result in harmful effects during safe handling and use. Ingestion Swallowing small amounts of this material during normal handling is not likely to cause harmfuleffects. Swallowing large amounts may be harmful. This material can get into the lungs duringswallowing or vomiting. This results in lung inflammation and other lung injury. Inhalation Breathing of vapor or mist is possible. Breathing this material may be harmful. Symptoms are not expected at air concentrations below the recommended exposure limits, if applicable (see Section 8.). Breathing air containing n-butyl acetate, which results from its use in aerosol applications, may cause delayed lung injury.

Medical Conditions Generally Aggravated by Exposure

Preexisting disorders of the following organs (or organ systems) may be aggravated by exposure to this material:, respiratory tract, skin, lung (for example, asthma-like conditions), liver, kidney, central nervous system, male reproductive system, auditory system, Individuals with preexisting heart disorders maybe more susceptible to arrhythmias (irregular heartbeats) if exposed to high concentrations of this material. Symptoms Signs and symptoms of exposure to this material through breathing, swallowing, and/or passage of the material through the skin may include:, metallic taste, redness of the face and neck, mouth andthroat irritation (soreness, dry or scratchy feeling, cough), stomach or intestinal upset (nausea, vomiting, diarrhea), irritation (nose, throat, airways), Lung irritation, tight feeling in the chest, central nervous system excitation (giddiness, liveliness, light-headed feeling) followed by central nervous systemdepression (dizziness, drowsiness, weakness, fatigue, nausea, headache, unconsciousness) and other central nervous system effects, temporary changes in mood and behavior, Weakness, respiratorydepression (slowing of the breathing rate), shortness of breath, loss of coordination, confusion, irregularheartbeat, narcosis (dazed or sluggish feeling), coma, and death. Target Organs Based on animal studies, exposure to methyl ethyl ketone (MEK) increases the onset of peripheral neuropathy caused by exposure to methyl butyl ketone (MBK), and/or n-hexane, and/or ethyl butylketone. MEK alone has not been shown to cause peripheral neuropathy., Prolonged intentional toluene abuse may lead to damage to many organ systems having effects on: central and peripheralnervous systems, vision, hearing, liver, kidneys, heart and blood. Such abuse has been associated with brain damage characterized by disturbances in gait, personality changes and loss of memory. Comparable central nervous system effects have not been shown to result from occupational exposure to toluene., Prolonged intentional toluene abuse may lead to hearing loss progressing to deafness. In addition, while noise is known to cause hearing loss in humans, it has been suggested that workersexposed to organic solvents, including toluene, along with noisemay suffer greater hearing loss than would be expected from exposure to noise alone., Overexposure to this material (or its components) has been suggested as a cause of the following effects in laboratory animals:, nasal damage, respiratory tract damage (nose, throat, and airways), testis damage, kidney damage, liver damage, effects on hearing,central nervous system damage, Overexposure to this material (or its components) has been suggested as a cause of the following effects in humans:, central nervous system effects, cardiac sensitization, kidney damage Carcinogenicity Ethylbenzene has been shown to cause cancer in laboratory animals. The relevance of thisfinding to humans is uncertain. The International Agency for Research on Cancer (IARC) has classifiedethylbenzene as a possible human carcinogen. Reproductive hazard This material (or a component) has been shown to cause birth defects in laboratory animalstudies. The relevance of these findings to humans is uncertain. Toluene may be harmful to the human fetus based on positive test results with laboratory animals. Case studies show that prolongedintentional abuse of toluene during pregnancy can cause birth defects inhumans.Ethyl 3-ethoxy propionate has been shown to cause harm to the fetus in laboratory animal studies. Harm to the fetus occurs only at exposure levels that harm the pregnant animal. The relevance of these findings to humans isuncertain.When tested separately, a minor component of propylene glycol monomethyl etheracetate (2-methoxy- 1 -propyl acetate) caused birth defects in experimental animals in one study but not in another. However, the commercial grade acetate containing the minor component did not cause birthdefects.