PB Bond, One Part Bonding Adhesive

SECTION 2: Hazards identification

Emergency Overview Contains dispenylmethane disocyanate (CAS No. 101-68-8) Inhalation MDI mists or vapors may cause respiratory irritation, breathlessness, chest discomfort, and reduced pulmonary function. Overexposure well above the PEL may result in bronchitis, bronchial spasms, and pulmonary edema. Long-term exposure to isocyanates has been reported to cause lung damage, including reduced lung function, which may be permanent. Acute or chronic overexposure to isocyanates may cause sensitization in some individuals resulting in allergic respiratory reactions including wheezing, shortness of breath and difficulty breathing.

Principle Routes of Exposure

Routes of entry for solids and liquids include eye and skin contact, ingestion, and inhalation. Routes of entry for gases include inhalation and eye contact. Skin contact may be a route of entry for liquified gases. Acute Toxicity: Information on MDI Of moderate toxicity after short-term inhalation. Virtually non-toxic after a single ingestion. Virtually non-toxic after a single skin contact. Inhalation of vapors may cause irritation of mucous membranes of the nose, throat, trachea, chest discomfort, difficult breathing, and reduced pulmonary function. Inhalation exposure well above the PEL may result additionally to eye irritation, headache, chemical bronchitis, asthma-like findings, or pulmonary edema. Isocyanates have also been report to cause hypersensitivity pneumonitis, which is characterized by flu-like symptoms, the onset of which may delayed. Gastrointestinal symptoms include nausea, vomiting, and abdominal pain. Irritation: Irritating to eyes, respiratory system and skin. Assessment Other Acute Effects: Causes temporary irritation of the respiratory tract. Sensitization: The substance may cause sensitization of the respiratory tract. Sensitization after skin contact possible. Studies in animals suggest that dermal exposure may lead to pulmonary sensitization. As a result of repeated overexposure of a single dose, certain individuals will develop isocyanate sensitization (chemical asthma), which will cause them to react to a later exposure at levels below PEL/TLV. Symptoms which include chest tightness , wheezing, cough, shortness of breath, or asthmatic attack, could be immediate or delayed up to several hours after exposure. Similar to many non-specific asthmatic responses, there are reports that once sensitized an individual can experience these symptoms upon exposure to dust, cold air, and other irritants. This increase lung sensitivity can persist for weeks and in severe cases for several years. Chronic overexposure of isocyanates has also been reported to cause lung damage, including a decrease in lung function, which may be permanent. Prolonged contact can cause reddening, swelling, rash, scaling, or blistering. In those who have developed a skin sensitization, these symptoms can develop as a result of contact with very small amounts of liquid material. or even as a result of vapor only exposure. Chronic Toxicity: Carcinogenicity: A carcinogenic potential cannot be excluded after long exposure to severely irritating concentrations. The effects are not relevant to humans at occupational levels of exposure. Repeated Dose Toxicity: The substance may cause damage to the olfactory epithelium after repeated inhalation. These effects are not relevant to humans at occupational levels of exposure. Reproductive Toxicity: Repeated inhalation does not cause damage to reproductive organs.

Teratogenic Effects

No malformations in animal studies found, however high doses was toxic in the development of parental animals. Genotoxicity: The substance was mutagenic in various bacterial test systems, however, these results could not be confirmed in tests with mammals. Aquatic Toxicity: The product may hydrolyse. The test result maybe partially due degradation products. The product has not been tested. The statement has been derived from products of a similar structure or composition. Information of Isocyanates As a result of previous repeated overexposures or a single large dose, certain individuals will develop isocyanate sensitization. (chemical asthma) which will cause them to react to a later exposure of isocyanate at levels well below the PEL/TLV. These symptoms, which include chest tightness, wheezing, coughing, shortness of breath, or asthmatic attack could be immediate or delayed up to several hours after exposure. Similar to many non-specific asthmatic responses, there are reports that once sensitized, an individual can experience these symptoms upon exposure to dust, cold air, or other irritants. The increased lung sensitivity can persist for weeks and in severe cases for several years. Chronic overexposure to isocyanates has been reported to cause lung damage, including a decrease in lung function, which may be permanent. Sensitization may be either temporary or permanent. Prolonged contact can cause reddening, swelling, rash, scaling, or blistering. In those who have developed a skin sensitization, these symptoms can develop as a result of contact with very small amounts of liquid material, or even as a result of vapor-only exposure.

Medical Conditions Generally Aggravated by Exposure

Overexposure The isocyanate component is a respiratory sensitizer. It may cause an allergic reaction leading to asthma like spasms of the bronchial tubes and difficulty in breathing. Person with history with respiratory disease or hypersensitivity should not be expose to the product. An animal study indicated that MDI may induce respiratory hypersensitivity following dermal exposure. Medical supervision of all employees who handle or come into contact with isocyanates is recommended. Pre-employment and periodic medical examinations with respiratory function tests (FEV,FVC as a minimum) are suggested. Persons with asthmatic conditions, chronic bronchitis, other chronic respiratory diseases, recurrent eczema or pulmonary sensitization should be excluded from working with isocyanates, further exposure is not recommended. Contact may aggravate pulmonary disorders.