(+) 1,2,3,9-tetrahydro-9-methyl-3- [(2-methyl-1H-imidazol- 1- yl) methyl]-4H-carbazol-4-one, monohydrochloride, dihydrate

SECTION 2: Hazards identification

Emergency Overview ONDANSETRON - ondansetron hydrochloride injection, is a solution containing ondansetron hydrochloride, a serotonin-blocking drug used intravenously or orally to prevent nausea and vomiting associated with the use of emetogenic cancer chemotherapy drugs, radiation induced nausea and vomiting, and to prevent post-operative nausea and vomiting. In the workplace, ondansetron hydrochloride should be considered a potent drug, possibly irritating to skin, and possibly severely irritating to the eyes and respiratory tract. Possible target organs include the central nervous system and liver. Occupational Exposure Potential Information on the absorption of this compound via ingestion, inhalation or skin contact is not available. Avoid liquid aerosol generation and skin contact with solution. Signs and Symptoms In the workplace, this material should be considered potentially irritating to the skin, and possibly severely irritating to the eyes and respiratory tract. Respiratory sensitization and allergy-like effects have also been reported following occupational exposures. In clinical use, adverse effects may include headache, restlessness, dizziness, hypotension, fever, malaise, fatigue, and diarrhea or constipation. Infrequently, elevations in liver function parameters and extrapyramidal symptoms have been reported. Also, rash, hypersensitivity, fever, bronchospasm and wheezing have been reported.

Medical Conditions Generally Aggravated by Exposure

Pre-existing hypersensitivity to ondansetron hydrochloride or other components in this product. Pre-existing central nervous system or liver ailments.