Pyridine

SECTION 2: Hazards identification

MAY CAUSE SEVERE EYE AND SKIN IRRITATION WITH POSSIBLE BURNS. FLAMMABLE LIQUID AND VAPOR. MAY CAUSE CENTRAL NERVOUS SYSTEM DEPRESSION. DANGER! STENCH. MAY BE HARMFUL IF SWALLOWED, INHALED, OR ABSORBED THROUGH THE SKIN. MAY CAUSE RESPIRATORY TRACT IRRITATION. TARGET ORGANS: BLOOD, KIDNEYS, CENTRAL NERVOUS SYSTEM, LIVER, EYES, SKIN, MUCOUS MEMBRANES.

Potential health effects

EYE: CONTACT WITH EYES MAY CAUSE SEVERE IRRITATION, AND POSSIBLE EYE BURNS. SKIN: MAY CAUSE SKIN IRRITATION. MAY BE HARMFUL IF ABSORBED THROUGH THE SKIN. EFFECTS MAY BE DELAYED. MAY CAUSE SMARTING OF THE SKIN AND FIRST-DEGREE BURNS ON SHORT EXPOSURE. SUBSTANCE IS READILY ABSORBED THROUGH THE SKIN. PYRIDINE WAS DETERMINED NOT TO BE A SKIN SENSITIZER IN GUINEA PIGS. INGESTION: MAY CAUSE GASTROINTESTINAL IRRITATION WITH NAUSEA, VOMITING AND DIARRHEA. MAY CAUSE LIVER AND KIDNEY DAMAGE. MAY CAUSE CENTRAL NERVOUS SYSTEM DEPRESSION, CHARACTERIZED BY EXCITEMENT, FOLLOWED BY HEADACHE, DIZZINESS, DROWSINESS, AND NAUSEA. ADVANCED STAGES MAY CAUSE COLLAPSE, UNCONSCIOUSNESS, COMA AND POSSIBLE DEATH DUE TO RESPIRATORY FAILURE. MAY CAUSE EFFECTS SIMILAR TO THOSE FOR INHALATION EXPOSURE. EFFECTS MAY BE DELAYED. INHALATION: INHALATION OF HIGH CONCENTRATIONS MAY CAUSE CENTRAL NERVOUS SYSTEM EFFECTS CHARACTERIZED BY NAUSEA, HEADACHE, DIZZINESS, UNCONSCIOUSNESS AND COMA. MAY CAUSE RESPIRATORY TRACT IRRITATION. PROLONGED EXPOSURE MAY RESULT IN DIZZINESS AND GENERAL WEAKNESS. OTHER SYMPTOMS REPORTED WITH ACUTE EXPOSURE TO PYRIDINE INCLUDE NERVOUSNESS, INSOMNIA, AND LOSS OF APPETITE. CHRONIC: PROLONGED OR REPEATED SKIN CONTACT MAY CAUSE DERMATITIS. CHRONIC INHALATION AND INGESTION MAY CAUSE EFFECTS SIMILAR TO THOSE OF ACUTE INHALATION AND INGESTION. MAY CAUSE LIVER AND KIDNEY DAMAGE. EXPOSURES TO DOSES OF PYRIDINE THAT ARE TOO LOW TO PRODUCE OVERT CLINICAL SYMPTOMS CAN CAUSE LIVER DAMAGE AND REPEATED LOW-LEVEL EXPOSURES CAN CAUSE CIRRHOSIS. FEEDING STUDIES IN RATS PRODUCED BLOOD EFFECTS LIKE CHANGES IN CLOTTING FACTORS.