SimpleChIP Plus Sonication Chromatin IP Kit

2.1 Classification of the substance or mixture

This substance/mixture is considered hazardous by the 2012 OSHA Hazard Communication Standard (29 CFR 1910.1200) _____________________________________________________________________________________________ _____________________________________________________________________________________________ glycine 56-40-6 5-10 Yes Kit Component Name ChIP Sonication Nuclear Lysis Buffer Chemical Name CAS No Weight % Hazardous polyethylene glycol 9002-93-1 1-<3 Yes p-(1,1,3,3-tetramethylbutyl)phen ylether Kit Component Name ChIP Sonication Cell Lysis Buffer (2X) Chemical Name CAS No Weight % Hazardous polyethylene glycol 9002-93-1 1-<3 Yes p-(1,1,3,3-tetramethylbutyl)phen ylether Kit Component Name ChIP Buffer (10X) Chemical Name CAS No Weight % Hazardous polyethylene glycol 9002-93-1 5-10 Yes p-(1,1,3,3-tetramethylbutyl)phen ylether trometamol 77-86-1 3-7 Yes glycine, 6381-92-6 1-5 Yes N,N'-1,2-ethanediylbis[N-(carbo xymethyl)-, sodium salt, hydrate 1 2 2) sodium 302-95-4 0.1-1 Yes 3-alpha,12-alphadihydroxy-5bet a-cholan-24-oate sodium dodecyl sulphate 151-21-3 0.1-1 Yes hydrochloric acid 7647-01-0 0.1-1 Yes Kit Component Name ChIP Elution Buffer (2X) Chemical Name CAS No Weight % Hazardous sodium dodecyl sulphate 151-21-3 1-5 Yes trometamol 77-86-1 1-5 Yes hydrochloric acid 7647-01-0 0.1-1 Yes Kit Component Name ChIP - Grade Protein G Magnetic Beads Chemical Name CAS No Weight % Hazardous sodium azide 26628-22-8 <=0.1 Yes Kit Component Name DNA Binding Buffer Chemical Name CAS No Weight % Hazardous propan-2-ol 67-63-0 30-60 Yes guanidinium chloride 50-01-1 30-60 Yes Kit Component Name Protease Inhibitor Cocktail (200X) Chemical Name CAS No Weight % Hazardous dimethyl sulfoxide 67-68-5 60-100 Yes benzenesulfonyl fluoride, 30827-99-7 1-5 Yes 4-(2-aminoethyl)-, hydrochloride (1:1) RNAse A (10 mg/ml) Kit Component Name Chemical Name CAS No Weight % Hazardous glycerol 56-81-5 30-60 Yes trometamol 77-86-1 10-15 Yes Kit Component Name Proteinase K (20 mg/ml) Chemical Name CAS No Weight % Hazardous glycerol 56-81-5 30-60 Yes _____________________________________________________________________________________________ _____________________________________________________________________________________________ Classification and label elements described below are inclusive of all hazards of the combined kit. The most severe classifications are listed for each endpoint. Refer to individual kit component SDS for classification and label elements for each component present in the kit. Acute oral toxicity Category 4 Skin corrosion/irritation Category 2 Serious eye damage/eye irritation Category 1 Respiratory sensitization Category 1 Specific target organ toxicity - single exposure (STOT SE) Category 3 Flammable liquids Category 2

Signal word

Danger

Hazard statements

Highly flammable liquid and vapor. Harmful if swallowed. Causes skin irritation. Causes serious eye damage. May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause drowsiness or dizziness. May cause respiratory irritation.

Precautionary statements

Wash face, hands and any exposed skin thoroughly after handling. Wear protective gloves/protective clothing/eye protection/face protection. Avoid breathing dust/fume/gas/mist/vapors/spray. In case of inadequate ventilation wear respiratory protection. Use only outdoors or in a well-ventilated area. Do not eat, drink or smoke when using this product. Keep away from heat/sparks/open �������������������������������������������������������������������������������������������������������������������� explosion-proof electrical/ventilating/lighting/ .? /equipment. Use only non-sparking tools. Take precautionary measures against static discharge. Keep cool. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Rinse mouth. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. Wash contaminated clothing before reuse. If skin irritation occurs: Get medical advice/attention. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician. In case of fire: Use CO2, dry chemical, or foam for extinction. Store in a well-ventilated place. Keep container tightly closed. Store locked up. Dispose of contents/container to an approved waste disposal plant. Supplementary Hazard Information No information available.

2.3 Other hazards

Not applicable. Unknown Acute Toxicity 15.269% of the mixture consists of ingredient(s) of unknown acute toxicity