General Information
Revision date
2018-10-25
Product name
Trametinib
Product Synonyms
N-[3-[3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]-acetamide; GSK1120212; JTP-74057; pyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]-acetamide; GSK1120212; JTP-74057;
1.2.1 Relevant identified uses
For research use only, not for human or veterinary use
Emergency telephone
+1 (800)424-9300, +1 (703)527-3887
Icons in SDS
Company Information
company name
Cayman Chemical Company
GHS Information
Signal word
Danger
Hazard Codes
Hazard statements (CLP)
H317, H361, H372
Hazard statements
Code
Statements
H317
May cause an allergic skin reaction
Section 2
SECTION 2: Hazards identification
Classification of the Substance or Mixture Skin Sensitization, Category 1 Toxic To Reproduction, Category 2 Specific Target Organ Toxicity (repeated exposure), Category 1
Signal word
Danger
Hazard statements
H317: May cause an allergic skin reaction. H361: Suspected of damaging fertility or the unborn child. H372: Causes damage to {heart, liver, kidney, oral} through prolonged or repeated exposure.
Precautionary statements
P261: Avoid breathing {dust/fume/gas/mist/vapours/spray}. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear {protective gloves/protective clothing/eye protection/face protection}. P362+364: Take off contaminated clothing and wash it before reuse. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P260: Do not breathe {dust/fume/gas/mist/vapours/spray}. P264: Wash {hands} thoroughly after handling.
Response
P302+352 IF ON SKIN Wash with plenty of soap and water P333+313: If skin irritation or rash occurs, seek medical advice/attention. P308+313 IF exposed or concerned Get medical attention/advice P314: Get medical attention/advice if you feel unwell.
Storage
Please refer to Section 7 for Storage and Section 13 for Disposal information.
Potential health effects
Causes damage to {heart, liver, kidney, oral} through prolonged or repeated exposure. Material may be irritating to the mucous membranes and upper respiratory tract. May be harmful by inhalation, ingestion, or skin absorption. May cause an allergic skin reaction. May cause eye, skin, or respiratory system irritation. Suspected of damaging fertility or the unborn child. To the best of our knowledge, the toxicological properties have not been thoroughly investigated.
2.1 Classification of the substance or mixture
Skin Sensitization, Category 1 Toxic To Reproduction, Category 2 Specific Target Organ Toxicity (repeated exposure), Category 1
