Temozolomide

Hazard statements (CLP)

H302, H315, H319, H335, H340, H360

Code

Statements

H302

Harmful if swallowed

CLP CLASSIFICATION

2.1.1 Classification according to Regulation (EC) No 1272/2008 [CLP]:]] Acute Toxicity: Oral, Category 4 Skin Corrosion/Irritation, Category 2 Serious Eye Damage/Eye Irritation, Category 2 Germ Cell Mutagenicity, Category 1B Toxic To Reproduction, Category 1B Target Organ Systemic Toxicity (single exposure), Category 3

EU Classification

Directive 1999/45/EC T: Toxic Carcinogenic Hazard: 2 Reproductive Hazard: 2 Mutagenic Hazard: 2

Hazard statements

R22, R36/37/38, R45, R46, R60, R61 For full text of R- phrases: see SECTION 15. H302: Harmful if swallowed. H315: Causes skin irritation. H319: Causes serious eye irritation. H340: May cause genetic defects. H360: May damage fertility or the unborn child. H335: May cause respiratory irritation.

2.2 Label elements

2.2.1 Labeling according to Regulation (EC) No 1272/2008 [CLP]:

Signal word

Danger

Precautionary statements

P264: Wash {hands} thoroughly after handling. P280: Wear {protective gloves/protective clothing/eye protection/face protection}. P362+364: Take off contaminated clothing and wash it before reuse. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P261: Avoid breathing {dust/fume/gas/mist/vapours/spray}.

Response

P301+312 IF SWALLOWED Call a POISON CENTER or doctor/physician if you feel unwell P330: Rinse mouth. P302+352 IF ON SKIN Wash with plenty of soap and water P332+313: If skin irritation occurs, get medical advice/attention. P305+351+338 IF IN EYES Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+313: If eye irritation persists, get medical advice/attention. P308+313 IF exposed or concerned Get medical attention/advice P309+311: Call a POISON CENTER or doctor/physician if exposed or you feel unwell. P304+340 IF INHALED Remove victim to fresh air and keep at rest in a position comfortable for breathing

Storage

Please refer to Section 7 for Storage and Section 13 for Disposal information. 2.2.2 Labeling according to Directive 1999/45/EC: T Carcinogenic Hazard 2; Reproductive Hazard 2; Mutagenic Hazard 2

Potential health effects

Causes skin irritation. Causes serious eye irritation. Harmful if swallowed. Material may be irritating to the mucous membranes and upper respiratory tract. May be harmful by inhalation, ingestion, or skin absorption. May cause eye, skin, or respiratory system irritation. May cause genetic defects. May cause respiratory irritation. May damage fertility or the unborn child. To the best of our knowledge, the toxicological properties have not been thoroughly investigated.