General Information
Revision date
2018-10-25
Product name
Pralatrexate
Product Synonyms
N-[4-[1-[(2,4-diamino-6-pteridinyl)methyl]-3-butyn-1-yl]benzoyl]-L-glutamic acid; NSC 754230; PDX; 10-Propargyl-10-deazaaminopterin;
1.2.1 Relevant identified uses
For research use only, not for human or veterinary use
Emergency telephone
+1 (800)424-9300, +1 (703)527-3887
Icons in SDS
Company Information
company name
Cayman Chemical Company
GHS Information
Signal word
Danger
Hazard Codes
Hazard statements (CLP)
H301, H311, H315, H319, H331, H335, H340, H351
Hazard statements
Code
Statements
H301
Toxic if swallowed
Section 2
SECTION 2: Hazards identification
Classification of the Substance or Mixture Acute Toxicity: Inhalation, Category 3 Acute Toxicity: Oral, Category 3 Acute Toxicity: Skin, Category 3 Skin Corrosion/Irritation, Category 2 Serious Eye Damage/Eye Irritation, Category 2 Germ Cell Mutagenicity, Category 1B Carcinogenicity, Category 2 Toxic To Reproduction, Category 1B Specific Target Organ Toxicity (single exposure), Category 3 Aquatic Toxicity (Chronic), Category 1
Signal word
Danger
Hazard statements
H301: Toxic if swallowed. H311: Toxic in contact with skin. H315: Causes skin irritation. H319: Causes serious eye irritation. H331: Toxic if inhaled. H335: May cause respiratory irritation. H340: May cause genetic defects {state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard}. H351: Suspected of causing cancer {state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard}. H360: May damage fertility or the unborn child {}. H410: Very toxic to aquatic life with long lasting effects.
Precautionary statements
P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P261: Avoid breathing {dust/fume/gas/mist/vapors/spray}. P264: Wash {hands} thoroughly after handling. P273: Avoid release to the environment. P280: Wear {protective gloves/protective clothing/eye protection/face protection}. P281: Use personal protective equipment as required.
Response
P301+310 IF SWALLOWED Immediately P311 Call a POISON CENTER or doctor/physician P302+352 IF ON SKIN Wash with plenty of soap and water P304+340 IF INHALED Remove victim to fresh air and keep at rest in a position comfortable for breathing P305+351+338 IF IN EYES Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P308+313 IF exposed or concerned Get medical attention/advice P321: Specific treatment {see ... on this label}. P330: Rinse mouth. P332+313: If skin irritation occurs, get medical advice/attention. P337+313: If eye irritation persists, get medical advice/attention. P361: Remove/Take off immediately all contaminated clothing. P363: Wash contaminated clothing before reuse. P391: Collect spillage.
Storage
P501: Dispose of contents/container to {...}.
Potential health effects
Causes serious eye irritation. Causes skin irritation. Material may be irritating to the mucous membranes and upper respiratory tract. May cause genetic defects. May cause respiratory system irritation. May damage fertility or the unborn child. Suspected of causing cancer. Toxic if inhaled, swallowed, or in contact with skin. Very toxic to aquatic life with long lasting effects. To the best of our knowledge, the toxicological properties have not been thoroughly investigated.
2.1 Classification of the substance or mixture
Acute Toxicity: Inhalation, Category 3 Acute Toxicity: Oral, Category 3 Acute Toxicity: Skin, Category 3 Skin Corrosion/Irritation, Category 2 Serious Eye Damage/Eye Irritation, Category 2 Germ Cell Mutagenicity, Category 1B Carcinogenicity, Category 2 Toxic To Reproduction, Category 1B Specific Target Organ Toxicity (single exposure), Category 3 Aquatic Toxicity (Chronic), Category 1
