Crizotinib

Hazard statements (CLP)

H317, H318, H341, H400

Code

Statements

H317

May cause an allergic skin reaction

2.1 Classification of the substance or mixture

Serious Eye Damage/Eye Irritation, Category 1 Skin Sensitization, Category 1 Germ Cell Mutagenicity, Category 2 Aquatic Toxicity (Acute), Category 1

Signal word

Danger

Hazard statements

H317: May cause an allergic skin reaction. H318: Causes serious eye damage. H341: Suspected of causing genetic defects. H400: Very toxic to aquatic life.

Precautionary statements

P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P261: Avoid breathing {dust/fume/gas/mist/vapors/spray}. P272: Contaminated work clothing should not be allowed out of the workplace. P273: Avoid release to the environment. P280: Wear {protective gloves/protective clothing/eye protection/face protection}.

Response

P302+352 IF ON SKIN Wash with plenty of soap and water P305+351+338 IF IN EYES Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P308+313 IF exposed or concerned Get medical attention/advice P310: Immediately call a POISON CENTER or doctor/physician. P333+313: If skin irritation or rash occurs, seek medical advice/attention. P362+364: Take off contaminated clothing and wash it before reuse. P391: Collect spillage.

Storage

Please refer to Section 7 for Storage and Section 13 for Disposal information.

Potential health effects

Causes serious eye damage. Material may be irritating to the mucous membranes and upper respiratory tract. May be harmful by inhalation, ingestion, or skin absorption. May cause an allergic skin reaction. May cause eye, skin, or respiratory system irritation. Suspected of causing genetic defects. Very toxic to aquatic life. To the best of our knowledge, the toxicological properties have not been thoroughly investigated.