Vincristine (sulfate)

Hazard statements (CLP)

H300, H315, H318, H331, H335, H336, H341, H350, H360, H373

Code

Statements

H300

Fatal if swallowed

SECTION 2: Hazards identification

NFPA Rating Classification of the substance or mixture d ~ GHS06 Skull and crossbones Acute toxicity - oral 2 H300 Fatal if swallowed Acute toxicity - inhalation 3 H331 Toxic if inhaled Contd. on page 2) US Contd. from page 1) d ~ GHS08 Health hazard Germ cell mutagenicity 2 H341 Suspected of causing genetic defects Carcinogenicity 1A H350 May cause cancer Reproductive toxicity 1B H360 May damage fertility or the unborn child Specific target organ toxicity (repeated exposure) 2 H373 May cause damage to organs through prolonged or repeated exposure d ~ GHS05 Corrosion Eye damage 1 H318 Causes serious eye damage d ~ GHS07 Skin irritation 2 H315 Causes skin irritation Specific target organ toxicity (single exposure) 3 H335-H336 May cause respiratory irritation. May cause drowsiness or dizziness

2.2 Label elements

The substance is classified and labeled according to the Globally Harmonized System (GHS).

Hazard pictograms

d ~ d ~ d ~ d ~ GHS05 GHS06 GHS07 GHS08

Signal word

Danger

Hazard statements

H300 Fatal if swallowed. H331 Toxic if inhaled. H315 Causes skin irritation. H318 Causes serious eye damage. H341 Suspected of causing genetic defects. H350 May cause cancer. H360 May damage fertility or the unborn child. H335-H336 May cause respiratory irritation. May cause drowsiness or dizziness. H373 May cause damage to organs through prolonged or repeated exposure.

Precautionary statements

P201 Obtain special instructions before use. P202 Do not handle until all safety precautions have been read and understood. P260 Do not breathe dust/fume/gas/mist/vapors/spray. P264 Wash thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection. P301+P310 If swallowed: Immediately call a poison center/doctor. (Contd. on page 3) US (Contd. from page 2) P321 Specific treatment (see on this label). P330 Rinse mouth. P302+P352 If on skin: Wash with plenty of water. P304+P340 If inhaled: Remove person to fresh air and keep comfortable for breathing. P305+P351+P338 If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P308+P313 IF exposed or concerned: Get medical advice/attention. P312 Call a poison center/doctor if you feel unwell. P314 Get medical advice/attention if you feel unwell. P362+P364 Take off contaminated clothing and wash it before reuse. P332+P313 If skin irritation occurs: Get medical advice/attention. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up. P501 Dispose of contents/container in accordance with local/regional/national/international regulations. · Information pertaining to particular dangers for man and environment

Classification system

· NFPA ratings (scale 0 - 4) Health = 4 0 Fire = 0 4 0 Reactivity = 0 · HMIS-ratings (scale 0 - 4) HEALTH *3 Health = *3 FIRE 0 Fire = 0 REACTIVITY 0 Reactivity = 0

PBT Substances

Not applicable

vPvB Substances

Not applicable

2.3 Other hazards

There are no adverse physical or health effects known that are not covered by the hazard classes of the Hazard Communications Standard.

2.1 Classification of the substance or mixture

d ~ GHS06 Skull and crossbones Acute toxicity - oral 2 H300 Fatal if swallowed. Acute toxicity - inhalation 3 H331 Toxic if inhaled. (Contd. on page 2) US (Contd. from page 1) d ~ GHS08 Health hazard Germ cell mutagenicity 2 H341 Suspected of causing genetic defects. Carcinogenicity 1A H350 May cause cancer. Reproductive toxicity 1B H360 May damage fertility or the unborn child. Specific target organ toxicity (repeated exposure) 2 H373 May cause damage to organs through prolonged or repeated exposure. d ~ GHS05 Corrosion Eye damage 1 H318 Causes serious eye damage. d ~ GHS07 Skin irritation 2 H315 Causes skin irritation. Specific target organ toxicity (single exposure) 3 H335-H336 May cause respiratory irritation. May cause drowsiness or dizziness.