General Information
Revision date
2025-10-08
Product name
Tucatinib
Product Synonyms
N6-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)-N4-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]-4,6-quinazolinediamine ARRY-380 ONT-380
CAS No.
937263-43-9
1.2.1 Relevant identified uses
This product is for research use - Not for human or veterinary diagnostic or therapeutic use
Emergency telephone
+1 (734) 971-3335, 800-424-9300
Icons in SDS
Company Information
company name
Cayman Chemical Co
GHS Information
Signal word
Warning
Hazard Codes
Hazard statements (CLP)
H302, H319, H361, H371, H373
Hazard statements
Code
Statements
H302
Harmful if swallowed
Section 2
SECTION 2: Hazards identification
NFPA Rating Classification of the substance or mixture d ~ GHS08 Health hazard Reproductive toxicity 2 H361 Suspected of damaging fertility or the unborn child Specific target organ toxicity (single exposure) 2 H371 May cause damage to organs Specific target organ toxicity (repeated exposure) 2 H373 May cause damage to organs through prolonged or repeated exposure d ~ GHS07 Acute toxicity - oral 4 H302 Harmful if swallowed Contd. from page 1) Eye irritation 2A H319 Causes serious eye irritation
2.2 Label elements
The substance is classified and labeled according to the Globally Harmonized System (GHS).
Hazard pictograms
d ~ d ~ GHS07 GHS08
Hazard statements
H302 Harmful if swallowed. H319 Causes serious eye irritation. H361 Suspected of damaging fertility or the unborn child. H371 May cause damage to organs. H373 May cause damage to organs through prolonged or repeated exposure.
Precautionary statements
P201 Obtain special instructions before use. P202 Do not handle until all safety precautions have been read and understood. P260 Do not breathe dust/fume/gas/mist/vapors/spray. P264 Wash thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection. P301+P312 If swallowed: Call a poison center/doctor if you feel unwell. P330 Rinse mouth. P305+P351+P338 If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P308+P313 IF exposed or concerned: Get medical advice/attention. P314 Get medical advice/attention if you feel unwell. P337+P313 If eye irritation persists: Get medical advice/attention. P405 Store locked up. P501 Dispose of contents/container in accordance with local/regional/national/international regulations. · Information pertaining to particular dangers for man and environment
Classification system
· NFPA ratings (scale 0 - 4) Health = 2 0 Fire = 0 2 0 Reactivity = 0 · HMIS-ratings (scale 0 - 4) HEALTH 2 Health = 2 FIRE 0 Fire = 0 REACTIVITY 0 Reactivity = 0
PBT Substances
Not applicable
vPvB Substances
Not applicable (Contd. from page 2)
2.3 Other hazards
There are no adverse physical or health effects known that are not covered by the hazard classes of the Hazard Communications Standard. *
2.1 Classification of the substance or mixture
d ~ GHS08 Health hazard Reproductive toxicity 2 H361 Suspected of damaging fertility or the unborn child. Specific target organ toxicity (single exposure) 2 H371 May cause damage to organs. Specific target organ toxicity (repeated exposure) 2 H373 May cause damage to organs through prolonged or repeated exposure. d ~ GHS07 Acute toxicity - oral 4 H302 Harmful if swallowed. (Contd. from page 1) Eye irritation 2A H319 Causes serious eye irritation.
