(R)-Crizotinib

Hazard statements (CLP)

H317, H319, H341, H400

Code

Statements

H317

May cause an allergic skin reaction

SECTION 2: Hazards identification

NFPA Rating Classification of the substance or mixture d ~ GHS08 Health hazard Germ cell mutagenicity 2 H341 Suspected of causing genetic defects d ~ GHS09 Environment Aquatic Acute 1 H400 Very toxic to aquatic life d ~ GHS07 Eye irritation 2A H319 Causes serious eye irritation Sensitization - skin 1 H317 May cause an allergic skin reaction Contd. from page 1)

2.2 Label elements

The substance is classified and labeled according to the Globally Harmonized System (GHS).

Hazard pictograms

d ~ d ~ d ~ GHS07 GHS08 GHS09

Hazard statements

H319 Causes serious eye irritation. H317 May cause an allergic skin reaction. H341 Suspected of causing genetic defects. H400 Very toxic to aquatic life.

Precautionary statements

P201 Obtain special instructions before use. P202 Do not handle until all safety precautions have been read and understood. P261 Avoid breathing dust/fume/gas/mist/vapors/spray P264 Wash thoroughly after handling. P272 Contaminated work clothing must not be allowed out of the workplace. P273 Avoid release to the environment. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection. P302+P352 If on skin: Wash with plenty of water. P305+P351+P338 If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P308+P313 IF exposed or concerned: Get medical advice/attention. P321 Specific treatment (see on this label). P362+P364 Take off contaminated clothing and wash it before reuse. P333+P313 If skin irritation or rash occurs: Get medical advice/attention. P337+P313 If eye irritation persists: Get medical advice/attention. P391 Collect spillage. P405 Store locked up. P501 Dispose of contents/container in accordance with local/regional/national/international regulations. · Information pertaining to particular dangers for man and environment

Classification system

· NFPA ratings (scale 0 - 4) Health = 2 0 Fire = 0 2 0 Reactivity = 0 · HMIS-ratings (scale 0 - 4) HEALTH 2 Health = 2 FIRE 0 Fire = 0 REACTIVITY 0 Reactivity = 0

PBT Substances

Not applicable

vPvB Substances

Not applicable (Contd. from page 2)

2.3 Other hazards

There are no adverse physical or health effects known that are not covered by the hazard classes of the Hazard Communications Standard. *

2.1 Classification of the substance or mixture

d ~ GHS08 Health hazard Germ cell mutagenicity 2 H341 Suspected of causing genetic defects. d ~ GHS09 Environment Aquatic Acute 1 H400 Very toxic to aquatic life. d ~ GHS07 Eye irritation 2A H319 Causes serious eye irritation. Sensitization - skin 1 H317 May cause an allergic skin reaction. (Contd. from page 1)