Nalmefene (hydrochloride)

Hazard statements (CLP)

H302, H302+H312+H332, H312, H315, H317, H319, H332, H334, H336

Code

Statements

H302

Harmful if swallowed

SECTION 2: Hazards identification

NFPA Rating Classification of the substance or mixture d ~ GHS08 Health hazard Sensitization - respiratory 1 H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled d ~ GHS07 Acute toxicity - oral 4 H302 Harmful if swallowed Acute toxicity - dermal 4 H312 Harmful in contact with skin Acute toxicity - inhalation 4 H332 Harmful if inhaled Skin irritation 2 H315 Causes skin irritation Eye irritation 2A H319 Causes serious eye irritation Sensitization - skin 1 H317 May cause an allergic skin reaction Contd. from page 1) Specific target organ toxicity (single exposure) 3 H336 May cause drowsiness or dizziness

2.2 Label elements

The substance is classified and labeled according to the Globally Harmonized System (GHS).

Hazard pictograms

d ~ d ~ GHS07 GHS08

Signal word

Danger

Hazard statements

H302+H312+H332 Harmful if swallowed, in contact with skin or if inhaled. H315 Causes skin irritation. H319 Causes serious eye irritation. H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled. H317 May cause an allergic skin reaction. H336 May cause drowsiness or dizziness.

Precautionary statements

P261 Avoid breathing dust/fume/gas/mist/vapors/spray P264 Wash thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area. P272 Contaminated work clothing must not be allowed out of the workplace. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection. P284 [In case of inadequate ventilation] wear respiratory protection. P301+P312 If swallowed: Call a poison center/doctor if you feel unwell. P330 Rinse mouth. P302+P352 If on skin: Wash with plenty of water. P304+P340 If inhaled: Remove person to fresh air and keep comfortable for breathing. P305+P351+P338 If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362+P364 Take off contaminated clothing and wash it before reuse. P333+P313 If skin irritation or rash occurs: Get medical advice/attention. P321 Specific treatment (see on this label). P337+P313 If eye irritation persists: Get medical advice/attention. P342+P311 If experiencing respiratory symptoms: Call a poison center/doctor. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up. P501 Dispose of contents/container in accordance with local/regional/national/international regulations. · Information pertaining to particular dangers for man and environment

Classification system

· NFPA ratings (scale 0 - 4) Health = 3 0 Fire = 0 3 0 Reactivity = 0 (Contd. from page 2) · HMIS-ratings (scale 0 - 4) HEALTH *2 Health = *2 FIRE 0 Fire = 0 REACTIVITY 0 Reactivity = 0

PBT Substances

Not applicable

vPvB Substances

Not applicable

EU Classification

(d)(1)(ii) of § 1910.12000 The SDS issuer does not object to the classifications provided by importers or manufacturers of precursor products.

2.3 Other hazards

There are no adverse physical or health effects known that are not covered by the hazard classes of the Hazard Communications Standard. *

2.1 Classification of the substance or mixture

d ~ GHS08 Health hazard Sensitization - respiratory 1 H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled. d ~ GHS07 Acute toxicity - oral 4 H302 Harmful if swallowed. Acute toxicity - dermal 4 H312 Harmful in contact with skin. Acute toxicity - inhalation 4 H332 Harmful if inhaled. Skin irritation 2 H315 Causes skin irritation. Eye irritation 2A H319 Causes serious eye irritation. Sensitization - skin 1 H317 May cause an allergic skin reaction. (Contd. from page 1) Specific target organ toxicity (single exposure) 3 H336 May cause drowsiness or dizziness.