(±)-Methadone (hydrochloride)

Hazard statements (CLP)

H300, H311, H311+H331, H315, H317, H319, H331, H334, H336, H341, H360, H411

Code

Statements

H300

Fatal if swallowed

SECTION 2: Hazards identification

NFPA Rating Classification of the substance or mixture d ~ GHS06 Skull and crossbones Acute toxicity - oral 1 H300 Fatal if swallowed Acute toxicity - dermal 3 H311 Toxic in contact with skin Acute toxicity - inhalation 3 H331 Toxic if inhaled d ~ GHS08 Health hazard Sensitization - respiratory 1 H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled Contd. from page 1) Germ cell mutagenicity 2 H341 Suspected of causing genetic defects Reproductive toxicity 1B H360 May damage fertility or the unborn child d ~ GHS09 Environment Aquatic Chronic 2 H411 Toxic to aquatic life with long lasting effects d ~ GHS07 Skin irritation 2 H315 Causes skin irritation Eye irritation 2A H319 Causes serious eye irritation Sensitization - skin 1 H317 May cause an allergic skin reaction Specific target organ toxicity (single exposure) 3 H336 May cause drowsiness or dizziness

2.2 Label elements

The substance is classified and labeled according to the Globally Harmonized System (GHS).

Hazard pictograms

d ~ d ~ d ~ d ~ GHS06 GHS07 GHS08 GHS09

Signal word

Danger

Hazard statements

H300 Fatal if swallowed. H311+H331 Toxic in contact with skin or if inhaled. H315 Causes skin irritation. H319 Causes serious eye irritation. H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled. H317 May cause an allergic skin reaction. H341 Suspected of causing genetic defects. H360 May damage fertility or the unborn child. H336 May cause drowsiness or dizziness. H411 Toxic to aquatic life with long lasting effects.

Precautionary statements

P201 Obtain special instructions before use. P202 Do not handle until all safety precautions have been read and understood. P261 Avoid breathing dust/fume/gas/mist/vapors/spray P264 Wash thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area. P272 Contaminated work clothing must not be allowed out of the workplace. P273 Avoid release to the environment. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection. P284 [In case of inadequate ventilation] wear respiratory protection. P301+P310 If swallowed: Immediately call a poison center/doctor. P321 Specific treatment (see on this label). P330 Rinse mouth. P302+P352 If on skin: Wash with plenty of water. (Contd. from page 2) P304+P340 If inhaled: Remove person to fresh air and keep comfortable for breathing. P305+P351+P338 If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P308+P313 IF exposed or concerned: Get medical advice/attention. P312 Call a poison center/doctor if you feel unwell. P361+P364 Take off immediately all contaminated clothing and wash it before reuse. P333+P313 If skin irritation or rash occurs: Get medical advice/attention. P337+P313 If eye irritation persists: Get medical advice/attention. P342+P311 If experiencing respiratory symptoms: Call a poison center/doctor. P391 Collect spillage. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up. P501 Dispose of contents/container in accordance with local/regional/national/international regulations. · Information pertaining to particular dangers for man and environment

Classification system

· NFPA ratings (scale 0 - 4) Health = 4 0 Fire = 0 4 0 Reactivity = 0 · HMIS-ratings (scale 0 - 4) HEALTH *3 Health = *3 FIRE 0 Fire = 0 REACTIVITY 0 Reactivity = 0

PBT Substances

Not applicable

vPvB Substances

Not applicable

2.3 Other hazards

There are no adverse physical or health effects known that are not covered by the hazard classes of the Hazard Communications Standard.

2.1 Classification of the substance or mixture

d ~ GHS06 Skull and crossbones Acute toxicity - oral 1 H300 Fatal if swallowed. Acute toxicity - dermal 3 H311 Toxic in contact with skin. Acute toxicity - inhalation 3 H331 Toxic if inhaled. d ~ GHS08 Health hazard Sensitization - respiratory 1 H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled. (Contd. from page 1) Germ cell mutagenicity 2 H341 Suspected of causing genetic defects. Reproductive toxicity 1B H360 May damage fertility or the unborn child. d ~ GHS09 Environment Aquatic Chronic 2 H411 Toxic to aquatic life with long lasting effects. d ~ GHS07 Skin irritation 2 H315 Causes skin irritation. Eye irritation 2A H319 Causes serious eye irritation. Sensitization - skin 1 H317 May cause an allergic skin reaction. Specific target organ toxicity (single exposure) 3 H336 May cause drowsiness or dizziness.