Dinaciclib

Hazard statements (CLP)

H315, H319, H340, H372

Code

Statements

H315

Causes skin irritation

SECTION 2: Hazards identification

NFPA Rating Classification of the substance or mixture d ~ GHS08 Health hazard Germ cell mutagenicity 1B H340 May cause genetic defects Specific target organ toxicity (repeated exposure) 1 H372 Causes damage to organs through prolonged or repeated exposure d ~ GHS07 Skin irritation 2 H315 Causes skin irritation Eye irritation 2A H319 Causes serious eye irritation

2.2 Label elements

The substance is classified and labeled according to the Globally Harmonized System (GHS). (Contd. from page 1)

Hazard pictograms

d ~ d ~ GHS07 GHS08

Signal word

Danger

Hazard statements

H315 Causes skin irritation. H319 Causes serious eye irritation. H340 May cause genetic defects. H372 Causes damage to organs through prolonged or repeated exposure.

Precautionary statements

P201 Obtain special instructions before use. P202 Do not handle until all safety precautions have been read and understood. P260 Do not breathe dust/fume/gas/mist/vapors/spray. P264 Wash thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection. P302+P352 If on skin: Wash with plenty of water. P305+P351+P338 If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P308+P313 IF exposed or concerned: Get medical advice/attention. P321 Specific treatment (see on this label). P314 Get medical advice/attention if you feel unwell. P362+P364 Take off contaminated clothing and wash it before reuse. P332+P313 If skin irritation occurs: Get medical advice/attention. P337+P313 If eye irritation persists: Get medical advice/attention. P405 Store locked up. P501 Dispose of contents/container in accordance with local/regional/national/international regulations. · Information pertaining to particular dangers for man and environment

Classification system

· NFPA ratings (scale 0 - 4) Health = 2 0 Fire = 0 2 0 Reactivity = 0 · HMIS-ratings (scale 0 - 4) HEALTH *2 Health = *2 FIRE 0 Fire = 0 REACTIVITY 0 Reactivity = 0

PBT Substances

Not applicable

vPvB Substances

Not applicable

2.3 Other hazards

There are no adverse physical or health effects known that are not covered by the hazard classes of the Hazard Communications Standard. *

2.1 Classification of the substance or mixture

d ~ GHS08 Health hazard Germ cell mutagenicity 1B H340 May cause genetic defects. Specific target organ toxicity (repeated exposure) 1 H372 Causes damage to organs through prolonged or repeated exposure. d ~ GHS07 Skin irritation 2 H315 Causes skin irritation. Eye irritation 2A H319 Causes serious eye irritation.