Cisplatin

Hazard statements (CLP)

H290, H300, H300+H310, H310, H315, H317, H318, H331, H334, H335, H340, H350, H360, H362, H372

Code

Statements

H290

May be corrosive to metals

SECTION 2: Hazards identification

NFPA Rating Classification of the substance or mixture d ~ GHS06 Skull and crossbones Acute toxicity - oral 2 H300 Fatal if swallowed Acute toxicity - dermal 1 H310 Fatal in contact with skin Acute toxicity - inhalation 3 H331 Toxic if inhaled Contd. from page 1) d ~ GHS08 Health hazard Sensitization - respiratory 1 H334 May cause allergy or asthm a symptoms or breathing difficulties if inhaled Germ cell mutagenicity 1A H340 May cause genetic defects Carcinogenicity 1A H350 May cause cancer Reproductive toxicity 1A H360-H362 May damage fertility or the unborn child. May cause harm to breast-fed children Specific target organ toxicity (repeated exposure) 1 H372 Causes damage to organs through prolonged or repeated exposure d ~ GHS05 Corrosion Corrosive to metals 1 H290 May be corrosive to metals Eye damage 1 H318 Causes serious eye damage d ~ GHS07 Skin irritation 2 H315 Causes skin irritation Sensitization - skin 1 H317 May cause an allergic skin reaction Specific target organ toxicity (single exposure) 3 H335 May cause respiratory irritation

2.2 Label elements

The substance is classified and labeled according to the Globally Harmonized System (GHS).

Hazard pictograms

d ~ d ~ d ~ d ~ GHS05 GHS06 GHS07 GHS08

Signal word

Danger

Hazard statements

H290 May be corrosive to metals. H300+H310 Fatal if swallowed or in contact with skin. H331 Toxic if inhaled. H315 Causes skin irritation. H318 Causes serious eye damage. H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled. H317 May cause an allergic skin reaction. H340 May cause genetic defects. H350 May cause cancer. H360-H362 May damage fertility or the unborn child. May cause harm to breast-fed children. H335 May cause respiratory irritation. H372 Causes damage to organs through prolonged or repeated exposure. (Contd. from page 2)

Precautionary statements

P201 Obtain special instructions before use. P202 Do not handle until all safety precautions have been read and understood. P234 Keep only in original packaging. P260 Do not breathe dusts or mists. P262 Do not get in eyes, on skin, or on clothing. P263 Avoid contact during pregnancy and /while nursing. P264 Wash thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area. P272 Contaminated work clothing must not be allowed out of the workplace. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection. P284 [In case of inadequate ventilation] wear respiratory protection. P301+P310 If swallowed: Immediately call a poison center/doctor. P321 Specific treatment (see on this label). P330 Rinse mouth. P302+P352 If on skin: Wash with plenty of water. P304+P340 If inhaled: Remove person to fresh air and keep comfortable for breathing. P305+P351+P338 If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P308+P313 IF exposed or concerned: Get medical advice/attention. P312 Call a poison center/doctor if you feel unwell. P314 Get medical advice/attention if you feel unwell. P361+P364 Take off immediately all contaminated clothing and wash it before reuse. P333+P313 If skin irritation or rash occurs: Get medical advice/attention. P342+P311 If experiencing respiratory symptoms: Call a poison center/doctor. P390 Absorb spillage to prevent material damage. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up. P406 Store in a corrosion resistant container / container with a resistant inner liner. P501 Dispose of contents/container in accordance with local/regional/national/international regulations. · Information pertaining to particular dangers for man and environment

Classification system

· NFPA ratings (scale 0 - 4) Health = 4 0 Fire = 0 4 0 Reactivity = 0 · HMIS-ratings (scale 0 - 4) HEALTH *4 Health = *4 FIRE 0 Fire = 0 REACTIVITY 0 Reactivity = 0

PBT Substances

Not applicable

vPvB Substances

Not applicable

2.3 Other hazards

There are no adverse physical or health effects known that are not covered by the hazard classes of the Hazard Communications Standard.

2.1 Classification of the substance or mixture

d ~ GHS06 Skull and crossbones Acute toxicity - oral 2 H300 Fatal if swallowed. Acute toxicity - dermal 1 H310 Fatal in contact with skin. Acute toxicity - inhalation 3 H331 Toxic if inhaled. (Contd. from page 1) d ~ GHS08 Health hazard Sensitization - respiratory 1 H334 May cause allergy or asthm a symptoms or breathing difficulties if inhaled. Germ cell mutagenicity 1A H340 May cause genetic defects. Carcinogenicity 1A H350 May cause cancer. Reproductive toxicity 1A H360-H362 May damage fertility or the unborn child. May cause harm to breast-fed children. Specific target organ toxicity (repeated exposure) 1 H372 Causes damage to organs through prolonged or repeated exposure. d ~ GHS05 Corrosion Corrosive to metals 1 H290 May be corrosive to metals. Eye damage 1 H318 Causes serious eye damage. d ~ GHS07 Skin irritation 2 H315 Causes skin irritation. Sensitization - skin 1 H317 May cause an allergic skin reaction. Specific target organ toxicity (single exposure) 3 H335 May cause respiratory irritation.