Cediranib

Hazard statements (CLP)

H301, H312, H315, H361, H372, H410

Code

Statements

H301

Toxic if swallowed

SECTION 2: Hazards identification

NFPA Rating Classification of the substance or mixture d ~ GHS06 Skull and crossbones Acute toxicity - oral 3 H301 Toxic if swallowed d ~ GHS08 Health hazard Reproductive toxicity 2 H361 Suspected of damaging fertility or the unborn child Specific target organ toxicity (repeated exposure) 1 H372 Causes damage to organs through prolonged or repeated exposure Contd. on page 2) US Contd. from page 1) d ~ GHS09 Environment Aquatic Chronic 1 H410 Very toxic to aquatic life with long lasting effects d ~ GHS07 Acute toxicity - dermal 4 H312 Harmful in contact with skin Skin irritation 2 H315 Causes skin irritation

2.2 Label elements

The substance is classified and labeled according to the Globally Harmonized System (GHS).

Hazard pictograms

d ~ d ~ d ~ d ~ GHS06 GHS07 GHS08 GHS09

Signal word

Danger

Hazard statements

H301 Toxic if swallowed. H312 Harmful in contact with skin. H315 Causes skin irritation. H361 Suspected of damaging fertility or the unborn child. H372 Causes damage to organs through prolonged or repeated exposure. H410 Very toxic to aquatic life with long lasting effects.

Precautionary statements

P201 Obtain special instructions before use. P202 Do not handle until all safety precautions have been read and understood. P260 Do not breathe dust/fume/gas/mist/vapors/spray. P264 Wash thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P273 Avoid release to the environment. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection. P301+P310 If swallowed: Immediately call a poison center/doctor. P321 Specific treatment (see on this label). P330 Rinse mouth. P302+P352 If on skin: Wash with plenty of water. P308+P313 IF exposed or concerned: Get medical advice/attention. P312 Call a poison center/doctor if you feel unwell. P314 Get medical advice/attention if you feel unwell. P362+P364 Take off contaminated clothing and wash it before reuse. P332+P313 If skin irritation occurs: Get medical advice/attention. P391 Collect spillage. P405 Store locked up. P501 Dispose of contents/container in accordance with local/regional/national/international regulations. (Contd. on page 3) US (Contd. from page 2) · Information pertaining to particular dangers for man and environment

Classification system

· NFPA ratings (scale 0 - 4) Health = 4 0 Fire = 0 4 0 Reactivity = 0 · HMIS-ratings (scale 0 - 4) HEALTH 3 Health = 3 FIRE 0 Fire = 0 REACTIVITY 0 Reactivity = 0

PBT Substances

Not applicable

vPvB Substances

Not applicable

2.3 Other hazards

There are no adverse physical or health effects known that are not covered by the hazard classes of the Hazard Communications Standard. *

2.1 Classification of the substance or mixture

d ~ GHS06 Skull and crossbones Acute toxicity - oral 3 H301 Toxic if swallowed. d ~ GHS08 Health hazard Reproductive toxicity 2 H361 Suspected of damaging fertility or the unborn child. Specific target organ toxicity (repeated exposure) 1 H372 Causes damage to organs through prolonged or repeated exposure. (Contd. on page 2) US (Contd. from page 1) d ~ GHS09 Environment Aquatic Chronic 1 H410 Very toxic to aquatic life with long lasting effects. d ~ GHS07 Acute toxicity - dermal 4 H312 Harmful in contact with skin. Skin irritation 2 H315 Causes skin irritation.