Camptothecin

Hazard statements (CLP)

H300, H335, H340, H350, H361, H372, H413

Code

Statements

H300

Fatal if swallowed

SECTION 2: Hazards identification

NFPA Rating Classification of the substance or mixture d ~ GHS06 Skull and crossbones Acute toxicity - oral 2 H300 Fatal if swallowed d ~ GHS08 Health hazard Germ cell mutagenicity 1B H340 May cause genetic defects Carcinogenicity 1B H350 May cause cancer Contd. on page 2) US Contd. from page 1) Reproductive toxicity 2 H361 Suspected of damaging fertility or the unborn child Specific target organ toxicity (repeated exposure) 1 H372 Causes damage to organs through prolonged or repeated exposure d ~ GHS07 Specific target organ toxicity (single exposure) 3 H335 May cause respiratory irritation Aquatic Chronic 4 H413 May cause long lasting harmful effects to aquatic life Label elements

2.2 Label elements

The substance is classified and labeled according to the Globally Harmonized System (GHS).

Hazard pictograms

d ~ d ~ d ~ GHS06 GHS07 GHS08

Signal word

Danger

Hazard statements

H300 Fatal if swallowed. H340 May cause genetic defects. H350 May cause cancer. H361 Suspected of damaging fertility or the unborn child. H335 May cause respiratory irritation. H372 Causes damage to organs through prolonged or repeated exposure. H413 May cause long lasting harmful effects to aquatic life.

Precautionary statements

P201 Obtain special instructions before use. P202 Do not handle until all safety precautions have been read and understood. P260 Do not breathe dust/fume/gas/mist/vapors/spray. P264 Wash thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area. P273 Avoid release to the environment. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection. P301+P310 If swallowed: Immediately call a poison center/doctor. P321 Specific treatment (see on this label). P330 Rinse mouth. P304+P340 If inhaled: Remove person to fresh air and keep comfortable for breathing. P308+P313 IF exposed or concerned: Get medical advice/attention. P312 Call a poison center/doctor if you feel unwell. P314 Get medical advice/attention if you feel unwell. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up. P501 Dispose of contents/container in accordance with local/regional/national/international regulations. (Contd. on page 3) US (Contd. from page 2) · Information pertaining to particular dangers for man and environment

Classification system

· NFPA ratings (scale 0 - 4) Health = 2 0 Fire = 0 2 0 Reactivity = 0 · HMIS-ratings (scale 0 - 4) HEALTH *2 Health = *2 FIRE 0 Fire = 0 REACTIVITY 0 Reactivity = 0

PBT Substances

Not applicable

vPvB Substances

Not applicable

2.3 Other hazards

There are no adverse physical or health effects known that are not covered by the hazard classes of the Hazard Communications Standard. *

2.1 Classification of the substance or mixture

d ~ GHS06 Skull and crossbones Acute toxicity - oral 2 H300 Fatal if swallowed. d ~ GHS08 Health hazard Germ cell mutagenicity 1B H340 May cause genetic defects. Carcinogenicity 1B H350 May cause cancer. (Contd. on page 2) US (Contd. from page 1) Reproductive toxicity 2 H361 Suspected of damaging fertility or the unborn child. Specific target organ toxicity (repeated exposure) 1 H372 Causes damage to organs through prolonged or repeated exposure. d ~ GHS07 Specific target organ toxicity (single exposure) 3 H335 May cause respiratory irritation. Aquatic Chronic 4 H413 May cause long lasting harmful effects to