Bortezomib

Hazard statements (CLP)

H300, H300+H310+H330, H310, H315, H318, H330, H360, H372, H400, H410

Code

Statements

H300

Fatal if swallowed

SECTION 2: Hazards identification

NFPA Rating Classification of the substance or mixture d ~ GHS06 Skull and crossbones Acute toxicity - oral 1 H300 Fatal if swallowed Acute toxicity - dermal 1 H310 Fatal in contact with skin Acute toxicity - inhalation 2 H330 Fatal if inhaled d ~ GHS08 Health hazard Contd. from page 1) Reproductive toxicity 1A H360 May damage fertility or the unborn child Specific target organ toxicity (repeated exposure) 1 H372 Causes damage to organs through prolonged or repeated exposure d ~ GHS05 Corrosion Eye damage 1 H318 Causes serious eye damage d ~ GHS09 Environment Aquatic Acute 1 H400 Very toxic to aquatic life Aquatic Chronic 1 H410 Very toxic to aquatic life with long lasting effects d ~ GHS07 Skin irritation 2 H315 Causes skin irritation

2.2 Label elements

The substance is classified and labeled according to the Globally Harmonized System (GHS).

Hazard pictograms

d ~ d ~ d ~ d ~ GHS05 GHS06 GHS08 GHS09

Signal word

Danger

Hazard statements

H300+H310+H330 Fatal if swallowed, in contact with skin or if inhaled. H315 Causes skin irritation. H318 Causes serious eye damage. H360 May damage fertility or the unborn child. H372 Causes damage to organs through prolonged or repeated exposure. H410 Very toxic to aquatic life with long lasting effects.

Precautionary statements

P201 Obtain special instructions before use. P202 Do not handle until all safety precautions have been read and understood. P260 Do not breathe dust/fume/gas/mist/vapors/spray. P262 Do not get in eyes, on skin, or on clothing. P264 Wash thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area. P273 Avoid release to the environment. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection. P284 [In case of inadequate ventilation] wear respiratory protection. P301+P310 If swallowed: Immediately call a poison center/doctor. P330 Rinse mouth. P302+P352 If on skin: Wash with plenty of water. (Contd. from page 2) P304+P340 If inhaled: Remove person to fresh air and keep comfortable for breathing. P305+P351+P338 If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P308+P313 IF exposed or concerned: Get medical advice/attention. P314 Get medical advice/attention if you feel unwell. P320 Specific treatment is urgent (see on this label). P361+P364 Take off immediately all contaminated clothing and wash it before reuse. P332+P313 If skin irritation occurs: Get medical advice/attention. P391 Collect spillage. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up. P501 Dispose of contents/container in accordance with local/regional/national/international regulations. · Information pertaining to particular dangers for man and environment

Classification system

· NFPA ratings (scale 0 - 4) Health = 4 0 Fire = 0 4 0 Reactivity = 0 · HMIS-ratings (scale 0 - 4) HEALTH *4 Health = *4 FIRE 0 Fire = 0 REACTIVITY 0 Reactivity = 0

PBT Substances

Not applicable

vPvB Substances

Not applicable

2.3 Other hazards

There are no adverse physical or health effects known that are not covered by the hazard classes of the Hazard Communications Standard. *

2.1 Classification of the substance or mixture

d ~ GHS06 Skull and crossbones Acute toxicity - oral 1 H300 Fatal if swallowed. Acute toxicity - dermal 1 H310 Fatal in contact with skin. Acute toxicity - inhalation 2 H330 Fatal if inhaled. d ~ GHS08 Health hazard (Contd. from page 1) Reproductive toxicity 1A H360 May damage fertility or the unborn child. Specific target organ toxicity (repeated exposure) 1 H372 Causes damage to organs through prolonged or repeated exposure. d ~ GHS05 Corrosion Eye damage 1 H318 Causes serious eye damage. d ~ GHS09 Environment Aquatic Acute 1 H400 Very toxic to aquatic life. Aquatic Chronic 1 H410 Very toxic to aquatic life with long lasting effects. d ~ GHS07 Skin irritation 2 H315 Causes skin irritation.