AZD 9291

Hazard statements (CLP)

H302, H317, H360, H372, H400, H410

Code

Statements

H302

Harmful if swallowed

SECTION 2: Hazards identification

NFPA Rating Classification of the substance or mixture d ~ GHS08 Health hazard Reproductive toxicity 1A H360 May damage fertility or the unborn child Specific target organ toxicity (repeated exposure) 1 H372 Causes damage to organs through prolonged or repeated exposure d ~ GHS09 Environment Aquatic Acute 1 H400 Very toxic to aquatic life Aquatic Chronic 1 H410 Very toxic to aquatic life with long lasting effects Contd. on page 2) US Contd. from page 1) d ~ GHS07 Acute toxicity - oral 4 H302 Harmful if swallowed Sensitization - skin 1 H317 May cause an allergic skin reaction

2.2 Label elements

The substance is classified and labeled according to the Globally Harmonized System (GHS).

Hazard pictograms

d ~ d ~ d ~ GHS07 GHS08 GHS09

Signal word

Danger

Hazard statements

H302 Harmful if swallowed. H317 May cause an allergic skin reaction. H360 May damage fertility or the unborn child. H372 Causes damage to organs through prolonged or repeated exposure. H410 Very toxic to aquatic life with long lasting effects.

Precautionary statements

P201 Obtain special instructions before use. P202 Do not handle until all safety precautions have been read and understood. P260 Do not breathe dust/fume/gas/mist/vapors/spray. P264 Wash thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P272 Contaminated work clothing must not be allowed out of the workplace. P273 Avoid release to the environment. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection. P301+P312 If swallowed: Call a poison center/doctor if you feel unwell. P330 Rinse mouth. P302+P352 If on skin: Wash with plenty of water. P308+P313 IF exposed or concerned: Get medical advice/attention. P321 Specific treatment (see on this label). P314 Get medical advice/attention if you feel unwell. P362+P364 Take off contaminated clothing and wash it before reuse. P333+P313 If skin irritation or rash occurs: Get medical advice/attention. P391 Collect spillage. P405 Store locked up. P501 Dispose of contents/container in accordance with local/regional/national/international regulations. · Information pertaining to particular dangers for man and environment

Classification system

· NFPA ratings (scale 0 - 4) Health = 2 0 Fire = 0 2 0 Reactivity = 0 (Contd. on page 3) US (Contd. from page 2) · HMIS-ratings (scale 0 - 4) HEALTH *2 Health = *2 FIRE 0 Fire = 0 REACTIVITY 0 Reactivity = 0

PBT Substances

Not applicable

vPvB Substances

Not applicable

2.3 Other hazards

There are no adverse physical or health effects known that are not covered by the hazard classes of the Hazard Communications Standard.

2.1 Classification of the substance or mixture

d ~ GHS08 Health hazard Reproductive toxicity 1A H360 May damage fertility or the unborn child. Specific target organ toxicity (repeated exposure) 1 H372 Causes damage to organs through prolonged or repeated exposure. d ~ GHS09 Environment Aquatic Acute 1 H400 Very toxic to aquatic life. Aquatic Chronic 1 H410 Very toxic to aquatic life with long lasting effects. (Contd. on page 2) US (Contd. from page 1) d ~ GHS07 Acute toxicity - oral 4 H302 Harmful if swallowed. Sensitization - skin 1 H317 May cause an allergic skin reaction.