Aprepitant

Hazard statements (CLP)

H302, H302+H312+H332, H312, H315, H318, H332, H335, H350, H373, H410

Code

Statements

H302

Harmful if swallowed

SECTION 2: Hazards identification

NFPA Rating Classification of the substance or mixture d ~ GHS08 Health hazard Carcinogenicity 1B H350 May cause cancer Specific target organ toxicity (repeated exposure) 2 H373 May cause damage to organs through prolonged or repeated exposure d ~ GHS05 Corrosion Eye damage 1 H318 Causes serious eye damage Contd. from page 1) d ~ GHS09 Environment Aquatic Chronic 1 H410 Very toxic to aquatic life with long lasting effects d ~ GHS07 Acute toxicity - oral 4 H302 Harmful if swallowed Acute toxicity - dermal 4 H312 Harmful in contact with skin Acute toxicity - inhalation 4 H332 Harmful if inhaled Skin irritation 2 H315 Causes skin irritation Specific target organ toxicity (single exposure) 3 H335 May cause respiratory irritation

2.2 Label elements

The substance is classified and labeled according to the Globally Harmonized System (GHS).

Hazard pictograms

d ~ d ~ d ~ d ~ GHS05 GHS07 GHS08 GHS09

Signal word

Danger

Hazard statements

H302+H312+H332 Harmful if swallowed, in contact with skin or if inhaled. H315 Causes skin irritation. H318 Causes serious eye damage. H350 May cause cancer. H335 May cause respiratory irritation. H373 May cause damage to organs through prolonged or repeated exposure. H410 Very toxic to aquatic life with long lasting effects.

Precautionary statements

P201 Obtain special instructions before use. P202 Do not handle until all safety precautions have been read and understood. P260 Do not breathe dust/fume/gas/mist/vapors/spray. P264 Wash thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area. P273 Avoid release to the environment. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection. P301+P312 If swallowed: Call a poison center/doctor if you feel unwell. P302+P352 If on skin: Wash with plenty of water. P304+P340 If inhaled: Remove person to fresh air and keep comfortable for breathing. P305+P351+P338 If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P310 Immediately call a poison center/doctor. P308+P313 IF exposed or concerned: Get medical advice/attention. P321 Specific treatment (see on this label). P314 Get medical advice/attention if you feel unwell. (Contd. from page 2) P330 Rinse mouth. P362+P364 Take off contaminated clothing and wash it before reuse. P332+P313 If skin irritation occurs: Get medical advice/attention. P391 Collect spillage. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up. P501 Dispose of contents/container in accordance with local/regional/national/international regulations. · Information pertaining to particular dangers for man and environment

Classification system

· NFPA ratings (scale 0 - 4) Health = 3 0 Fire = 0 3 0 Reactivity = 0 · HMIS-ratings (scale 0 - 4) HEALTH *3 Health = *3 FIRE 0 Fire = 0 REACTIVITY 0 Reactivity = 0

PBT Substances

Not applicable

vPvB Substances

Not applicable

2.3 Other hazards

There are no adverse physical or health effects known that are not covered by the hazard classes of the Hazard Communications Standard. *

2.1 Classification of the substance or mixture

d ~ GHS08 Health hazard Carcinogenicity 1B H350 May cause cancer. Specific target organ toxicity (repeated exposure) 2 H373 May cause damage to organs through prolonged or repeated exposure. d ~ GHS05 Corrosion Eye damage 1 H318 Causes serious eye damage. (Contd. from page 1) d ~ GHS09 Environment Aquatic Chronic 1 H410 Very toxic to aquatic life with long lasting effects. d ~ GHS07 Acute toxicity - oral 4 H302 Harmful if swallowed. Acute toxicity - dermal 4 H312 Harmful in contact with skin. Acute toxicity - inhalation 4 H332 Harmful if inhaled. Skin irritation 2 H315 Causes skin irritation. Specific target organ toxicity (single exposure) 3 H335 May cause respiratory irritation.