Panoptical fast staining - Fixative

Hazard statements (CLP)

H225, H301, H301+H311+H331, H311, H331, H370

Code

Statements

H225

Highly Flammable liquid and vapour

SECTION 2: Hazards identification

According to Regulation (EC) No 1272/2008 [CLP Classification of the substance or mixture

Hazard categories

Cat- Hazard class and Hazard egory category statement 2.6 Flammable liquid Flam. Liq. 2 H225 3.1O Acute toxicity (oral) Acute Tox. 3 H301 3.1D Acute toxicity (dermal) Acute Tox. 3 H311 3.1I Acute toxicity (inhal.) Acute Tox. 3 H331 Section Cat- Hazard class and Hazard egory category statement 3.8 Specific target organ toxicity - single exposure STOT SE 1 H370 For full text of abbreviations: see SECTION 16

Most important adverse effects

Immediate effects can be expected after short-term exposure. The product is combustible and can be ignited by potential ignition sources

Signal word

Danger Danger Not required

Hazard pictograms

GHS02, GHS06, GHS08 H301+H311+H331 Toxic if swallowed, in contact with skin or if inhaled. H370 Causes damage to organs (eye). P280 Wear protective clothing/eye protection. P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor. P308+P311 IF exposed or concerned: Call a POISON CENTER/doctor.

Hazard statements

H225 Highly flammable liquid and vapour H301+H311+H331 Toxic if swallowed, in contact with skin or if inhaled H370 Causes damage to organs (eye) Not required

Prevention

P210 Keep away from heat, sparks, open flames, hot surfaces. No smoking P280 Wear protective clothing/eye protection

Response

P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water [or shower] P308+P311 IF exposed or concerned: Call a POISON CENTER/doctor

Hazardous Ingredients

Methanol Labelling of packages where the contents do not exceed 125 ml

Contains

Methanol Labelling of packages where the contents do not exceed 10 ml

Precautionary statements

Not required

Results of PBT and vPvB assessment

Does not contain a PBT-/vPvB-substance at a concentration of ≥ 0,1%. Endocrine disrupting properties Does not contain an endocrine disruptor (ED) at a concentration of ≥ 0,1%.

2.1 Classification of the substance or mixture

Classification according to Regulation (EC) No 1272/2008 (CLP) Section Hazard class Cat- Hazard class and Hazard egory category statement 2.6 Flammable liquid 2 Flam. Liq. 2 H225 3.1O Acute toxicity (oral) 3 Acute Tox. 3 H301 3.1D Acute toxicity (dermal) 3 Acute Tox. 3 H311 3.1I Acute toxicity (inhal.) 3 Acute Tox. 3 H331 Section Hazard class Cat- Hazard class and Hazard egory category statement 3.8 Specific target organ toxicity - single exposure 1 STOT SE 1 H370 For full text of abbreviations: see SECTION 16 The most important adverse physicochemical, human health and environmental effects Immediate effects can be expected after short-term exposure. The product is combustible and can be ignited by potential ignition sources. 2.2 Label elements Labelling according to Regulation (EC) No 1272/2008 (CLP) Signal word Danger Pictograms GHS02, GHS06, GHS08 Hazard statements H225 Highly flammable liquid and vapour H301+H311+H331 Toxic if swallowed, in contact with skin or if inhaled H370 Causes damage to organs (eye) Precautionary statements Precautionary statements - prevention P210 Keep away from heat, sparks, open flames, hot surfaces. No smoking P280 Wear protective clothing/eye protection Precautionary statements - response P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water [or shower] P308+P311 IF exposed or concerned: Call a POISON CENTER/doctor Hazardous ingredients for labelling: Methanol Labelling of packages where the contents do not exceed 125 ml Signal word: Danger Hazard pictogram(s): H301+H311+H331 Toxic if swallowed, in contact with skin or if inhaled. H370 Causes damage to organs (eye). P280 Wear protective clothing/eye protection. P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor. P308+P311 IF exposed or concerned: Call a POISON CENTER/doctor. contains: Methanol Labelling of packages where the contents do not exceed 10 ml Signal word: Not required Hazard pictogram(s): Hazard statements: Not required Precautionary statements: Not required 2.3 Other hazards Results of PBT and vPvB assessment Does not contain a PBT-/vPvB-substance at a concentration of ≥ 0,1%. Endocrine disrupting properties Does not contain an endocrine disruptor (ED) at a concentration of ≥ 0,1%. SECTION 3: Composition/information on ingredients 3.1 Substances not relevant (mixture) 3.2 Mixtures Description of the mixture Name of sub- Identifier Wt% Classification acc. to Pictograms Notes stance GHS Methanol CAS No 95 – < 100 Flam. Liq. 2 / H225 GHS-HC 67-56-1 Acute Tox. 3 / H301 IOELV Acute Tox. 3 / H311 EC No Acute Tox. 3 / H331 200-659-6 STOT SE 1 / H370 Index No 603-001-00-X REACH Reg. No 01-2119433307- 44-xxxx Notes GHS-HC: Harmonised classification (the classification of the substance corresponds to the entry in the list according to 1272/2008/EC, Annex VI) IOELV: Substance with a community indicative occupational exposure limit value Name of sub- Identifier Specific Conc. Limits M-Factors ATE Exposure stance route Methanol CAS No STOT SE 1; H370: C ≥ 10 % - 100 mg/kg oral 67-56-1 STOT SE 2; H371: 3 % ≤ C < 10 % 300 mg/kg dermal 3 mg/l/4h inhalation: va- EC No pour 200-659-6 Index No 603-001-00-X Remarks For full text of abbreviations: see SECTION 16 SECTION 4: First aid measures 4.1 Description of first aid measures General notes Take off immediately all contaminated clothing. Self-protection of the first aider. Following inhalation Call a physician immediately. If breathing is irregular or stopped, administer artificial respiration. Following skin contact After contact with skin, wash immediately with plenty of water. Following eye contact Rinse cautiously with water for several minutes. In all cases of doubt, or when symptoms persist, seek medical advice. Following ingestion Rinse mouth immediately and drink plenty of water. Call a physician immediately. 4.2 Most important symptoms and effects, both acute and delayed Following inhalation: Cough, Vertigo, Headache, Following skin contact: Has degreasing effect on the skin, After eye contact: Conjunctival redness of the eyes, Conjunctivitis (pink eye), Following ingestion: Abdominal pain, Malaise, Vomiting, Poisoning effect on central nervous system can cause convulsions, laboured breathing and loss of consciousness, Loss of righting reflex, and ataxia, Serious physical decay of vision, Risk of blindness, Large doses may result in coma and death 4.3 Indication of any immediate medical attention and special treatment needed none SECTION 5: Firefighting measures 5.1 Extinguishing media Suitable extinguishing media co-ordinate firefighting measures to the fire surroundings! water spray, alcohol resistant foam, dry extinguishing powder, BC-powder, carbon dioxide (CO₂) Unsuitable extinguishing media water jet 5.2 Special hazards arising from the substance or mixture Combustible. In case of insufficient ventilation and/or in use, may form flammable/explosive vapour- air mixture. Solvent vapours are heavier than air and may spread along floors. Places which are not ventilated, e.g. unventilated below ground level areas such as trenches, conduits and shafts, are par- ticularly prone to the presence of flammable substances or mixtures. Vapours may form explosive mixtures with air. Hazardous combustion products Carbon monoxide (CO), Carbon dioxide (CO₂), May produce toxic fumes of carbon monoxide if burn- ing. 5.3 Advice for firefighters In case of fire and/or explosion do not breathe fumes. Fight fire with normal precautions from a reas- onable distance. Wear self-contained breathing apparatus. Wear full chemical protective clothing. SECTION 6: Accidental release measures 6.1 Personal precautions, protective equipment and emergency procedures For non-emergency personnel Use personal protective equipment as required. Avoid contact with skin, eyes and clothes. Do not breathe vapour/spray. Avoidance of ignition sources. 6.2 Environmental precautions Keep away from drains, surface and ground water. Retain contaminated washing water and dispose of it. 6.3 Methods and material for containment and cleaning up Advice on how to contain a spill Covering of drains. Advice on how to clean up a spill Absorb with liquid-binding material (sand, diatomaceous earth, acid- or universal binding agents). Other information relating to spills and releases Place in appropriate containers for disposal. Ventilate affected area. 6.4 Reference to other sections Hazardous combustion products: see section 5. Personal protective equipment: see section 8. Incom- patible materials: see section 10. Disposal considerations: see section 13. SECTION 7: Handling and storage 7.1 Precautions for safe handling Provision of sufficient ventilation. Use extractor hood (laboratory). Handle and open container with care. Clear contaminated areas thoroughly. Measures to prevent fire as well as aerosol and dust generation Keep away from sources of ignition - No smoking.