Lysis Buffer LSR

Hazard statements (CLP)

H302, H302+H312+H332, H312, H314, H318, H332, H412

Code

Statements

H302

Harmful if swallowed

SECTION 2: Hazards identification

According to Regulation (EC) No 1272/2008 [CLP Classification of the substance or mixture

Hazard categories

Cat- Hazard class and Hazard egory category statement 3.1O Acute toxicity (oral) Acute Tox. 4 H302 3.1D Acute toxicity (dermal) Acute Tox. 4 H312 3.1I Acute toxicity (inhal.) Acute Tox. 4 H332 3.2 Skin corrosion/irritation 1B Skin Corr. 1B H314 Section Cat- Hazard class and Hazard egory category statement 3.3 Serious eye damage/eye irritation Eye Dam. 1 H318 4.1C Hazardous to the aquatic environment - chronic hazard Aquatic Chronic 3 H412 Supplemental hazard information Code Supplemental hazard information EUH032 contact with acids liberates very toxic gas For full text of abbreviations: see SECTION 16

Most important adverse effects

Skin corrosion produces an irreversible damage to the skin; namely, visible necrosis through the epi- dermis and into the dermis. Spillage and fire water can cause pollution of watercourses

Signal word

Danger Danger Not required

Hazard pictograms

GHS05, GHS07 H314 Causes severe skin burns and eye damage. H412 Harmful to aquatic life with long lasting effects. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. EUH032 Contact with acids liberates very toxic gas.

Hazard statements

H302+H312+H332 Harmful if swallowed, in contact with skin or if inhaled H314 Causes severe skin burns and eye damage H412 Harmful to aquatic life with long lasting effects Not required

Prevention

P261 Avoid breathing mist/vapours P273 Avoid release to the environment

Response

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing P312 Call a POISON CENTRE/doctor if you feel unwell

Supplemental label elements

EUH032 Contact with acids liberates very toxic gas.

Hazardous Ingredients

Guanidine thiocyanate Labelling of packages where the contents do not exceed 125 ml

Contains

Guanidine thiocyanate Labelling of packages where the contents do not exceed 10 ml

Precautionary statements

Not required

Results of PBT and vPvB assessment

Does not contain a PBT-/vPvB-substance at a concentration of ≥ 0,1%. Endocrine disrupting properties Does not contain an endocrine disruptor (ED) at a concentration of ≥ 0,1%.

2.1 Classification of the substance or mixture

Classification according to Regulation (EC) No 1272/2008 (CLP) Section Hazard class Cat- Hazard class and Hazard egory category statement 3.1O Acute toxicity (oral) 4 Acute Tox. 4 H302 3.1D Acute toxicity (dermal) 4 Acute Tox. 4 H312 3.1I Acute toxicity (inhal.) 4 Acute Tox. 4 H332 3.2 Skin corrosion/irritation 1B Skin Corr. 1B H314 Section Hazard class Cat- Hazard class and Hazard egory category statement 3.3 Serious eye damage/eye irritation 1 Eye Dam. 1 H318 4.1C Hazardous to the aquatic environment - chronic hazard 3 Aquatic Chronic 3 H412 Supplemental hazard information Code Supplemental hazard information EUH032 contact with acids liberates very toxic gas For full text of abbreviations: see SECTION 16 The most important adverse physicochemical, human health and environmental effects Skin corrosion produces an irreversible damage to the skin; namely, visible necrosis through the epi- dermis and into the dermis. Spillage and fire water can cause pollution of watercourses. 2.2 Label elements Labelling according to Regulation (EC) No 1272/2008 (CLP) Signal word Danger Pictograms GHS05, GHS07 Hazard statements H302+H312+H332 Harmful if swallowed, in contact with skin or if inhaled H314 Causes severe skin burns and eye damage H412 Harmful to aquatic life with long lasting effects Precautionary statements Precautionary statements - prevention P261 Avoid breathing mist/vapours P273 Avoid release to the environment Precautionary statements - response P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing P312 Call a POISON CENTRE/doctor if you feel unwell Supplemental hazard information EUH032 Contact with acids liberates very toxic gas. Hazardous ingredients for labelling: Guanidine thiocyanate Labelling of packages where the contents do not exceed 125 ml Signal word: Danger Hazard pictogram(s): H314 Causes severe skin burns and eye damage. H412 Harmful to aquatic life with long lasting effects. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. EUH032 Contact with acids liberates very toxic gas. contains: Guanidine thiocyanate Labelling of packages where the contents do not exceed 10 ml Signal word: Not required Hazard pictogram(s): Hazard statements: Not required Precautionary statements: Not required 2.3 Other hazards Results of PBT and vPvB assessment Does not contain a PBT-/vPvB-substance at a concentration of ≥ 0,1%. Endocrine disrupting properties Does not contain an endocrine disruptor (ED) at a concentration of ≥ 0,1%. SECTION 3: Composition/information on ingredients 3.1 Substances not relevant (mixture) 3.2 Mixtures Description of the mixture Name of sub- Identifier Wt% Classification acc. to Pictograms Notes stance GHS Guanidine thiocyanate CAS No 25 – 50 Acute Tox. 4 / H302 A 593-84-0 Acute Tox. 4 / H312 GHS-HC Acute Tox. 4 / H332 EC No Skin Corr. 1B / H314 209-812-1 Eye Dam. 1 / H318 Aquatic Chronic 3 / H412 Index No 615-004-00-3 Notes A: Without prejudice to Article 17(2), the name of the substance must appear on the label in the form of one of the desig- nations given in Part 3. In Part 3, use is sometimes made of a general description such as ‘... compounds’ or ‘... salts’. In this case, the supplier is required to state on the label the correct name, due account being taken of section 1.1.1.4. GHS-HC: Harmonised classification (the classification of the substance corresponds to the entry in the list according to 1272/2008/EC, Annex VI) Name of sub- Identifier Specific Conc. Limits M-Factors ATE Exposure stance