HigherPurity Blood Genomic DNA Extraction Kit

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture

Classification (67/548/CEE) or

Hazardous Ingredients

No hazardous ingredients S3 Buffer Substance / Mixture: Proprietary compound mixture No hazardous ingredients Proteinase K (lyophilized) Chemical name: Proteinase K CAS No: 39450-01-6 EB Buffer Contains no hazardous substances in concentrations to be declared

2.2 Label elements

S1 Buffer

Hazard statements

XN Harmful R 36/37/38 Irritating to eyes, respiratory system and skin. R 42 Irritant - may cause sensitization by inhalation and skin contact. EB Buffer

2.3 Other hazards

NA. 3. FIRST AID MEASURES 3.1. DESCRIPTION OF DIRTS AID MEASURES Inhalation: Move to fresh air in case of accidental inhalation of vapours or decomposition products. If symptoms persist, call a physician. Ingestion: Clean mouth with water and afterwards drinks plenty of water. Do not induce vomiting. Consult a physician for severe cases. Skin contact: Wash off immediately with plenty of water. In the case of skin irritation or allergic reactions see a physician. Eye contact: Rinse immediately with plenty of water, also under the eyelids. Consult a physician. 3.2. MOST IMPORTANT SYMPTOMS AND EFFECTS, BOTH ACUTE AND DELAYED NA. 3.3. INDICATION OF ANY IMMEDIATE MEDICAL ATTENTION AND SPECIAL TREATMENT NEEDED NA. 4. FIRE FIGHTING MEASURES 4.1. EXTINGUISHING MEDIA No restriction.. 4.2. SPECIAL HAZARDS ARISING FROM THE SUBSTANCE OR MIXTURE None. 4.3. ADVICE FOR FIRE FIGHTERS These products do not burn themselves. Use extinguishing measures that are appropriate to local circumstances and the surrounding environment. 5. ACCIDENTAL RELEASE MEASURES 5.1. PERSONAL PRECAUTIONS, PROTECTIVE EQUIPMENT AND EMERGENCY PROCEDURES Advice for non-emergency personnel: Avoid inhalation of dusts. Avoid substance contact. Ensure adequate ventilation. Keep away from heat and sources of ignition. Evacuate the danger area, observe emergency procedures, consult an expert. For personal protection see section 8. 5.2. ENVIRONMENTAL PRECAUTIONS No restriction. 5.3. METHODS AND MATERIAL FOR CONTAINMENT AND CLEANING UP Sweep up spilled solids carefully. Dilute spilled liquids with plenty of water and adsorb. 5.4. REFERENCE TO OTHER SECTIONS For disposal see section 13. 6. HANDLING AND STORAGE 6.1. PRECAUTIONS FOR SAFE HANDLING When using, do not eat, drink or smoke. Avoid contact with skin and eyes. Wash hands before breaks and at the end of workday. Take off all contaminated clothing immediately. 6.2. CONDITIONS FOR SAFE STORAGE INCLUDING ANY INCOMPATIBILITIES Normal measures for preventive fire protection. 6.3. SPECIFIC END USE(S) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated. 7. EXPOSURE CONTROLS / PERSONAL PROTECTION 7.1. CONTROL PARAMETERS No data available. 7.2. EXPOSURE CONTROLS Special protective equipment Eye/face protection The following protection should be worn Safety glasses Hand protection It is recommended that gloves be made of the following materials Nitrile rubber Other skin and body protection: Wear rubber apron. Wear rubber footwear. Respiratory protection: In case of insufficient ventilation wear suitable respiratory equipment. 8. PHYSICAL AND CHEMICAL PROPERTIES 8.1. BASIC INFORMATION ON PHYSICAL AND CHEMICAL PROPERTIES S1 Buffer Appearance: Colourless, Liquid. Odor: Odorless. Solubility(ies): No data available S2 Buffer Appearance: Colourless, Liquid. Odor: Odorless. Solubility(ies): No data available S3 Buffer Appearance: Colourless, Liquid. Odor: Odorless. Solubility(ies): No data available pH: No data available ProteinaseK Appearance: Solid. Odor: Characteristic. Solubility(ies): No data available pH: no data available

Further information

Not determinated. 9. STABILITY AND REACTIVITY 9.1. REACTIVITY No decomposition if stored and applied as directed. 9.2. CHEMICAL STABILITY No decomposition if stored and applied as directed. 9.3. POSSIBILITY OF HAZARDOUS REACTIONS Stable under recommended storage conditions. 9.4. CONDITIONS TO AVOID No data available. 9.5. INCOMPATIBLE MATERIALS No data available. 9.6. HAZARDOUS DECOMPOSITION PRODUCTS No decomposition if stored and applied as directed. 10. TOXICOLOGICAL INFORMATION 10.1. INFORMATION ON TOXICOLOGICAL EFFECTS Inhalation: May cause respiratory irritation by inhalation. -S1 Buffer; S2 Buffer; S3 Buffer; and EB Buffer. Acute toxicity: No data available. Potential health effects: Eyes – may be irritating to eyes with susceptible persons. Non-corrosive for the eyes. Skin – may be slightly irritating to skin. Non-corrosive for the skin. Inhalation –may be irritating to respiratory system. Non-corrosive for lungs. -Proteinase K (lyophilized); Acute toxicity: No data available. Irritant effect: Irritating to eyes, skin, mucous membranes and respiratory tract. Sensitization: May cause sensitization through inhalation or skin contact. 11. ECOLOGICAL INFORMATION Ecotoxicity: The components of the product are not classified as hazardous to the environment. Large or frequent spills may have harmful effects on the environment. 11.1. TOXICITY No data available. 11.2. PERSISTENCE AND DEGRADABILITY No data available 11.3. BIOACCUMULATION POTENTIAL MOBILITY IN THE SOIL No data available. 11.4. PBT AND vPvBm ASSESSMENT RESULTS This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher. 11.5. OTHER ADVERSE EFFECTS Not determined. 12. DISPOSAL CONSIDERATIONS 12.1. WASTE TREATMENT METHODS No information required. General information: Used reagent can be disposed of in the waste water in accordance with local regulations. Disposal methods: Dispose of empty packs by local recycling or waste disposal routes if necessary, clean them beforehand.. 13. TRANSPORT INFORMATION 13.1. UN-NUMBER None. 13.2. UN PROPER SHIPPING NAME ADR/RID FLAMMABLE SOLID None IMDG: FLAMMABLE SOLID, None IATA: Flammable solid, None 13.3. TRANSPORT HAZARD CLASS(ES) ADR/RID - IMDG - IATA - 13.4. PACKAGING GROUP ADR/RID - IMDG - IATA - 13.5. ENVIRONMENTAL HAZARDS Hazardous pollutant substance/marine pollutant: No. 13.6. SPECIAL PRECAUTIONS FOR USER No information required. 13.7. TRANSPORT IN BULK ACCORDING TO ANNEX II MARPOL73/78 AND THE IBC CODE No information required. 14. REGULATORY INFORMATION 14.1. SAFETY, HEALTH AND ENVIRONMENTAL REGULATIONS/LEGISLATION SPECIFIC FOR THE SUBSTANCE OR MIXTURE National Provisions: The Chemicals (Hazard Information and Packaging for Supply) Regulations 2009 (SI 2009 No. 716). EU Legislation: Regulation (EC) No 1907/2006 of the European Parliament and of the Council of 18 December 2006 concerning the Registration, Evaluation, Authorization and Restriction of Chemicals (REACH) (as amended). Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008 on classification, labeling and packaging of substances and mixtures (as amended). Guidance: CHIP for everyone HSG228. Safety Data Sheets for Substances and Preparations. Approved Classification and Labelling Guide (Sixth edition) L131. Hazard Classification for water: WGK 2 14.2. CHEMICAL SAFETY ASSESSMENT Any chemical safety assessment has been carried out.