Vitamin B1 Thiamine Mononitrate 98% DCS

SECTION 2: Hazards identification

Regulation (EC) No. 1272/2008 Classification of the substance or mixture Classification according to

Hazard pictograms

Not Applicable

Signal word

NOT APPLICABLE

Hazard statements

Not Applicable

Supplemental label elements

Not Applicable

Prevention

Not Applicable

Response

Not Applicable

Storage

Not Applicable

Disposal

Not Applicable

2.3 Other hazards

Cumulative effects may result following exposure*. REACh - Art.57-59: The mixture does not contain Substances of Very High Concern (SVHC) at the SDS print date.

2.1 Classification of the substance or mixture

Classification according to regulation (EC) No 1272/2008 Not Applicable [CLP] [1] 2.2. Label elements Hazard pictogram(s) Not Applicable SIGNAL WORD NOT APPLICABLE Hazard statement(s) Not Applicable Supplementary statement(s) Not Applicable Precautionary statement(s) Prevention Not Applicable Precautionary statement(s) Response Not Applicable Precautionary statement(s) Storage Not Applicable Precautionary statement(s) Disposal Not Applicable 2.3. Other hazards Cumulative effects may result following exposure*. REACh - Art.57-59: The mixture does not contain Substances of Very High Concern (SVHC) at the SDS print date. SECTION 3 COMPOSITION / INFORMATION ON INGREDIENTS 3.1.Substances See 'Composition on ingredients' in Section 3.2 3.2.Mixtures 1.CAS No 2.EC No %[weight] Name Classification according to regulation (EC) No 1272/2008 [CLP] 3.Index No 4.REACH No 1.532-43-4 2.208-537-4 3.Not Available 98 thiamine mononitrate Not Applicable 4.Not Available 1.9004-65-3 2.Not Available 2 hydroxypropyl methylcellulose Not Applicable 3.Not Available 4.Not Available Legend: 1. Classified by Chemwatch; 2. Classification drawn from EC Directive 67/548/EEC - Annex I ; 3. Classification drawn from EC Directive 1272/2008 - Annex VI 4. Classification drawn from C&L SECTION 4 FIRST AID MEASURES 4.1. Description of first aid measures Eye Contact Generally not applicable. Skin Contact Generally not applicable. If dust is inhaled, remove from contaminated area. Inhalation Encourage patient to blow nose to ensure clear passage of breathing. If irritation or discomfort persists seek medical attention. Generally not applicable. Ingestion Generally not applicable. 4.2 Most important symptoms and effects, both acute and delayed See Section 11 4.3. Indication of any immediate medical attention and special treatment needed Treat symptomatically. SECTION 5 FIREFIGHTING MEASURES 5.1. Extinguishing media Foam. Dry chemical powder. BCF (where regulations permit). Carbon dioxide. Water spray or fog - Large fires only. 5.2. Special hazards arising from the substrate or mixture Fire Incompatibility Avoid contamination with oxidising agents i.e. nitrates, oxidising acids, chlorine bleaches, pool chlorine etc. as ignition may result 5.3. Advice for firefighters Alert Fire Brigade and tell them location and nature of hazard. Fire Fighting Wear breathing apparatus plus protective gloves. Prevent, by any means available, spillage from entering drains or water courses. Use water delivered as a fine spray to control fire and cool adjacent area. DO NOT approach containers suspected to be hot. Cool fire exposed containers with water spray from a protected location. If safe to do so, remove containers from path of fire. Equipment should be thoroughly decontaminated after use. Slight hazard when exposed to heat, flame and oxidisers. Combustible. Will burn if ignited. Combustion products include: carbon monoxide (CO) carbon dioxide (CO2) Fire/Explosion Hazard nitrogen oxides (NOx) sulfur oxides (SOx) other pyrolysis products typical of burning organic material. Articles and manufactured articles may constitute a fire hazard where polymers form their outer layers or where combustible packaging remains in place. Certain substances, found throughout their construction, may degrade or become volatile when heated to high temperatures. This may create a secondary hazard. SECTION 6 ACCIDENTAL RELEASE MEASURES 6.1. Personal precautions, protective equipment and emergency procedures See section 8 6.2. Environmental precautions See section 12 6.3. Methods and material for containment and cleaning up Clean up all spills immediately. Secure load if safe to do so. Minor Spills Bundle/collect recoverable product. Collect remaining material in containers with covers for disposal. Minor hazard. Clear area of personnel. Alert Fire Brigade and tell them location and nature of hazard. Wear physical protective gloves e.g. Leather. Major Spills Contain spill/secure load if safe to do so. Bundle/collect recoverable product and label for recycling. Collect remaining product and place in appropriate containers for disposal. Clean up/sweep up area. Water may be required. 6.4. Reference to other sections Personal Protective Equipment advice is contained in Section 8 of the SDS. SECTION 7 HANDLING AND STORAGE 7.1. Precautions for safe handling Limit all unnecessary personal contact. Wear protective clothing when risk of exposure occurs. Use in a well-ventilated area. Avoid contact with incompatible materials. When handling, DO NOT eat, drink or smoke. Safe handling Keep containers securely sealed when not in use. Avoid physical damage to containers. Always wash hands with soap and water after handling. Work clothes should be laundered separately. Use good occupational work practice. Observe manufacturer's storage and handling recommendations contained within this SDS. Atmosphere should be regularly checked against established exposure standards to ensure safe working conditions are maintained. Fire and explosion protection See section 5 Store away from incompatible materials. Other information 7.2. Conditions for safe storage, including any incompatibilities Generally packaging as originally supplied with the article or manufactured item is sufficient to protect against physical hazards. Suitable container If repackaging is required ensure the article is intact and does not show signs of wear. As far as is practicably possible, reuse the original packaging or something providing a similar level of protection to both the article and the handler. Glass container is suitable for laboratory quantities Avoid contamination of water, foodstuffs, feed or seed. Cellulose and its derivatives may react vigorously with calcium oxide, bleaching powder, perchlorates, perchloric acid, sodium chlorate, fluorine, nitric acid, Storage incompatibility sodium nitrate and sodium nitrite. May be incompatible with aminacrine hydrochloride, chlorocresol, mercuric chloride, phenol, resorcinol, tannic acid and silver nitrate. Protect from light. Avoid reaction with oxidising agents 7.3. Specific end use(s) See section 1.2 SECTION 8 EXPOSURE CONTROLS / PERSONAL PROTECTION 8.1. Control parameters DERIVED NO EFFECT LEVEL (DNEL) Not Available PREDICTED NO EFFECT LEVEL (PNEC) Not Available OCCUPATIONAL EXPOSURE LIMITS (OEL) INGREDIENT DATA Source Ingredient Material name TWA STEL Peak Notes Not Available EMERGENCY LIMITS Ingredient Material name TEEL-1 TEEL-2 TEEL-3 Not Available 98% DCS Ingredient Original IDLH Revised IDLH thiamine mononitrate Not Available hydroxypropyl methylcellulose Not Available Not Available 8.2. Exposure controls Articles or manufactured items, in their original condition, generally don't require engineering controls during handling or in normal use. Exceptions may arise following extensive use and subsequent wear, during recycling or disposal operations where substances, found in the article, may be released to the environment. Enclosed local exhaust ventilation is required at points of dust, fume or vapour generation. HEPA terminated local exhaust ventilation should be considered at point of generation of dust, fumes or vapours. Barrier protection or laminar flow cabinets should be considered for laboratory scale handling. A fume hood or vented balance enclosure is recommended for weighing/ transferring quantities exceeding 500 mg. When handling quantities up to 500 gram in either a standard laboratory with general dilution ventilation (e.g. 6-12 air changes per hour) is preferred. Quantities up to 1 kilogram may require a designated laboratory using fume hood, biological safety cabinet, or approved vented enclosures. Quantities exceeding 1 kilogram should be handled in a designated laboratory or containment laboratory using appropriate barrier/ containment technology. Manufacturing and pilot plant operations require barrier/ containment and direct coupling technologies. Barrier/ containment technology and direct coupling (totally enclosed processes that create a barrier between the equipment and the room) typically use double or split butterfly valves and hybrid unidirectional airflow/ local exhaust ventilation solutions (e.g. powder containment booths). Glove bags, isolator glove box systems are optional. HEPA filtration of exhaust from dry product handling areas is required. Fume-hoods and other open-face containment devices are acceptable when face velocities of at least 1 m/s (200 feet/minute) are achieved. Partitions, barriers, and other partial containment technologies are required to prevent migration of the material to uncontrolled areas. For non-routine emergencies maximum local and general exhaust are necessary. Air contaminants generated in the workplace possess varying 'escape' velocities which, in turn, determine the 'capture velocities' of fresh circulating air required to effectively remove the contaminant. Type of Contaminant: Air Speed: 8.2.1. Appropriate engineering controls 0.25-0.5 m/s (50-100 solvent, vapours, etc. evaporating from tank (in still air) f/min.) aerosols, fumes from pouring operations, intermittent container filling, low speed conveyer transfers (released at low velocity 0.5-1 m/s (100-200 into zone of active generation) f/min.) 1-2.5 m/s (200-500 direct spray, drum filling, conveyer loading, crusher dusts, gas discharge (active generation into zone of rapid air motion) f/min.) Within each range the appropriate value depends on: Lower end of the range Upper end of the range 1: Room air currents minimal or favourable to capture 1: Disturbing room air currents 2: Contaminants of low toxicity or of nuisance value only. 2: Contaminants of high toxicity 3: Intermittent, low production. 3: High production, heavy use 4: Large hood or large air mass in motion 4: Small hood-local control only Simple theory shows that air velocity falls rapidly with distance away from the opening of a simple extraction pipe. Velocity generally decreases with the square of distance from the extraction point (in simple cases). Therefore the air speed at the extraction point should be adjusted, accordingly, after reference to distance from the contaminating source. The air velocity at the extraction fan, for example, should be a minimum of 1-2.5 m/s (200-500 f/min.) for extraction of gases discharged 2 meters distant from the extraction point. Other mechanical considerations, producing performance deficits within the extraction apparatus, make it essential that theoretical air velocities are multiplied by factors of 10 or more when extraction systems are installed or used. The need for respiratory protection should also be assessed where incidental or accidental exposure is anticipated: Dependent on levels of contamination, PAPR, full face air purifying devices with P2 or P3 filters or air supplied respirators should be evaluated. The following protective devices are recommended where exposures exceed the recommended exposure control guidelines by factors of: 10; high efficiency particulate (HEPA) filters or cartridges 10-25; loose-fitting (Tyvek or helmet type) HEPA powered-air purifying respirator. 25-50; a full face-piece negative pressure respirator with HEPA filters 50-100; tight-fitting, full face-piece HEPA PAPR 100-1000; a hood-shroud HEPA PAPR or full face-piece supplied air respirator operated in pressure demand or other positive pressure mode. 8.2.2. Personal protection Safety glasses. Safety glasses with side shields. Chemical goggles. Contact lenses may pose a special hazard; soft contact lenses may absorb and concentrate irritants. A written policy document, describing the wearing of lenses or restrictions on use, should be created for each workplace or task. This should include a review of lens absorption and adsorption for the class of chemicals in use and an account of injury experience. Medical and first-aid personnel should be trained in their removal and suitable equipment should be readily available. In the event of chemical exposure, begin eye irrigation immediately and remove contact lens as soon as practicable. Lens should be removed at the first signs of eye redness or irritation - lens should be removed in a clean environment only after workers have washed hands thoroughly. [CDC NIOSH Current Intelligence Bulletin 59], [AS/NZS 1336 or national equivalent] No special equipment for minor exposure i.e. when handling small quantities. OTHERWISE: Safety glasses with side shields. Contact lenses may pose a special hazard; soft contact lenses may absorb and concentrate irritants. A written policy document, describing the wearing of lenses or restrictions on use, should be created for each workplace or task. This should include a review of lens absorption and adsorption for the class of chemicals in use and an account of injury experience. Medical and first-aid personnel should be trained in their removal and suitable equipment should be readily available. In the event of chemical exposure, begin eye irrigation immediately and remove contact lens as soon as practicable. Lens should be removed at the first signs of eye redness or irritation - lens should be removed in a clean environment only after workers have washed hands thoroughly. [CDC NIOSH Current Intelligence Bulletin 59], [AS/NZS 1336 or national equivalent] Eye and face protection Safety glasses with side shields Chemical goggles. Contact lenses may pose a special hazard; soft contact lenses may absorb and concentrate irritants. A written policy document, describing the wearing of lenses or restrictions on use, should be created for each workplace or task. This should include a review of lens absorption and adsorption for the class of chemicals in use and an account of injury experience. Medical and first-aid personnel should be trained in their removal and suitable equipment should be readily available. In the event of chemical exposure, begin eye irrigation immediately and remove contact lens as soon as practicable. Lens should be removed at the first signs of eye redness or irritation - lens should be removed in a clean environment only after workers have washed hands thoroughly. [CDC NIOSH Current Intelligence Bulletin 59], [AS/NZS 1336 or national equivalent] When handling very small quantities of the material eye protection may not be required.