pyrimethamine

British Pharmacopoeia Commission

Revision date : 2025-11-17

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GHS07 GHS08 GHS09
Health risk rating 5
Safety risk rating 1
Environmental risk rating 4

General Information

Version

1.01

Revision date

2025-11-17

Product name

pyrimethamine

Substance name

Pyrimethamine

CAS No.

58-14-0

1.2.1 Relevant identified uses

Laboratory use

supplier name

British Pharmacopoeia Commission

Emergency telephone

+44 (0)20 3080 6561

Icons in SDS

GHS07 GHS08 GHS09 M004 M009 M010 M011 M017

Company Information

company name

British Pharmacopoeia Commission

e-mail address of the competent person responsible for the Safety Data Sheet

bpcrs@mhra.gov.uk

GHS Information

Signal word

Danger

Hazard Codes

Hazard statements (CLP)

H302, H319, H341, H360D, H362, H373, H411

Hazard statements

Code

Statements

H302

Harmful if swallowed

Section 2

SECTION 2: Hazards identification

Regulation (EC) No. 1272/2008 [CLP]] Classification of the substance or mixture Classification according to

Contains

Pyrimethamine

Signal word

Danger

Hazard statements

H302 - Harmful if swallowed. H319 - Causes serious eye irritation. H341 - Suspected of causing genetic defects. H360D - May damage the unborn child. H362 - May cause harm to breast-fed children. H373 - May cause damage to organs through prolonged or repeated exposure. H411 - Toxic to aquatic life with long lasting effects.

Precautionary statements

P201 - Obtain special instructions before use P260 - Do not breathe dust, fume, gas, mist, vapors and spray P263 - Avoid contact during pregnancy and while nursing P273 - Avoid release to the environment P280 - Wear protective gloves, protective clothing, eye protection and face protection P308 + P313 - IF exposed or concerned: Get medical advice/attention P391 - Collect spillage P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing P337 + P313 - If eye irritation persists: Get medical advice/attention

2.3 Other hazards

Toxic to aquatic life.

PBT Substances

& vPvB This substance does not meet the PBT/vPvB criteria of REACH, annex XIII. Endocrine Disruptor Information This product does not contain any known or suspected endocrine disruptors. Chemical name

2.1 Classification of the substance or mixture

Classification according to Regulation (EC) No. 1272/2008 [CLP] Acute toxicity - Oral Category 4 - (H302) Eye irritation Category 2 - (H319) Germ cell mutagenicity Category 2 - (H341) Reproductive toxicity Category 1B - (H360D) Effects on or via lactation Yes - (H362) Specific target organ toxicity (repeated exposure) Category 2 - (H373) Hazardous to the aquatic environment - chronic Category 2 - (H411)

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