090048

Aspiration hazard

Negative This technical / safety data sheet replaces the previous ones. 17-36 Specific target Target organ(s): organ toxicity- respiratory system, May single exposure cause respiratory irritation (STOT-SE). inhalative Specific target Target organ(s): organ toxicity- respiratory system, repeated Positive exposure (STOT- RE), INHALAT Methylenediphenyl diisocyanate, modified Toxicity/effect Endpo Value Unit Organism Test method Notes int Acute toxicity, by LD50 >500 Mg/kg Rat oral route 0 Acute toxicity, by LD50 >940 Mg/kg Rabbit dermal route 0 Acute toxicity, by LC50 0,49 Mg/l/4h Rat Aerosol, Does not conform inhalation with EU classification Skin Rabbit OECD 404 Irritant corrosion/irritatio (Acute n dermal irritation/cor rosion) Serious eye Rabbit OECD 405 Irritant damage/irritation (Acute Eye Irritation/Cor rosion) Respiratory or Guinea pig OECD 406 Sentisitising (inhalation skin sensitization (Skin and skin contact) sensitization) Gem cell OECD 471 Negative mutagenicity (Bacterial Reverse Mutation Test) Aspiration No Symptoms Dibutylbis(dodecylthio)stannane Acute toxicity, by dermal LD50 >1000 route N,N-bis(3- aminopropyl)methylamin e Acute toxicity, by oral route LD50 691 Acute toxicity, by dermal LD50 200 route Acute toxicity, by inhalation LC50 0,07 Talc Skin corrosion/irritation Serious eye damage/irritation Respiratory or skin sensitization Germ cell mutagenicity Carcinogenicity Reproductive toxicity Symptoms This technical / safety data sheet replaces the previous ones. Last review: 04/01/2019 www.bossauto.com Mg/l/4 Calculat h ed value, vapours Mg/l/4 Calculat h ed value, aerosol n.d.a Mg/kg Rabbit Analogo us conclusi on Mg/kg Rat Mg/kg Rabbit Mg/l/4 Rat h Not irritant Not irritant Not sensitizis ing Negative Mucous membra ne irritation 22-36 Silica, amorphous Acute toxicity, by oral route LD50 >5000 Mg/kg Rat Acute toxicity, by dermal LD50 >2000 Mg/kg Rat OECD 403 (Acute route Dermal Toxicity) Acute toxicity, by inhalation LC50 >0,691 Mg/l/4 Rat h Skin corrosion/irritation OECD 404 (Acute Not dermal irritant Irritation/Corrosion Serious eye Not damage/irritation irritant Germ cell mutagenicity OECD 471 Negative (Bacterial Reverse Mutation Test)

SECTION 2: Hazards identification

Symptoms: Weatering eyes, breathing difficulties, asthmatic, symptoms, coughing Specific target Irritation of the respiratory organ toxicity- tract single exposure (STOT-SE), inhalative 4,4’-methylenediphenyl diisocyanate This technical / safety data sheet replaces the previous ones. 18-36 Acute toxicity, by LD50 >200 Mg/kg Rat Analogous conclusion oral route 0 Richlinie 84/449/EWG,B1 Acute toxicity, by LD50 >940 Mg/kg Rabbit OECD 402 Analogous conclusion dermal route 0 (Acute dermal toxicity) Acute toxicity, by LC50 0,368 Mg/l/4h Rat OECD 403 Analogous conclusion. inhalation (Acute Prüfatmosphäre: Inhalation Staub/Nebel toxicity) Skin Rabbit OECD 404 Irritant, analogous corrosion/irritatio (Acute conclusion n dermal irritation/cor rosion) Serious eye Rabbit OECD 405 Not irritant, analogous damage/irritation (Acute eye conclusion irritation/cor rosion) Respiratory or Mouse OECD 429 Positive Sensibilisierung skin sensitization (Skin durch Hautkontakt möglich Sensitisation – Local Lymph Node Assay) Respiratory or Guinea pig OECD 406 Negative Verursacht keine skin sensitisation (Skin Hautsensibilisierung sensitisation) Germ cell Rat In vivo Negative mutagenicity Germ cell Salmonella In vitro Negative, analogous mutagenicity typhimurium conclusion Carcinogenicity Rat OECD 453 Aerosol, Studies on (Combined carcinogeneric effects in Chronic animal experiments. Toxicity/Carc Analogous conclusion” inogenicity Studies) Reproductive NOAE 4 Mg/m3 Rat OECD 414 Analogous conclusion, toxicity L (Prenatal Aerosol Development al Toxicity Study) Reproductive NOAE 0,004 Mg/l Rat OECD 414 Analogous conclusion, toxicity L (Prenatal Aerosol (Developmental Development toxicity) al Toxicity Study) Reproductive NOAE 12 Rat OECD 414 Analogous conclusion, toxicity (Effects L (Prenatal Aerosol on fertility) Development al Toxicity This technical / safety data sheet replaces the previous ones. 19-36 Study) Specific target May cause respiratory organ toxicity- irritation single exposure (STOT-SE) INHALATIVE Specific target Target organ(s): organ toxicity- respiratory system, Acute repeated Tox.4 exposure (STOT- RE), inhalat Specific target LOAE 1 Mg/m3 Rat OECD 453 Target organ(s): organ toxicity- L (Combined respiratory system, repeated Chronic irritation of the respiratory exposure (STOT- Toxicity/Carc tract, Aerosol, Analogous RE), inhalat inogenicity conclusion Studies) Expositionsdauer:2a Specific target NOAE 0,2 Mg/m3 Rat OECD 453 Target organ(s): organ toxicity- L (Combined respiratory system, repeated Chronic irritation of the respiratory exposure (STOT- Toxicity/Carc tract. Aerosol, Analogous RE), inhalat: inogenicity conclusion Studies) Expositionsdauer:2a Talc Skin Not irritant corrosion/irritatio n Serious eye Not irritant damage/irritation Respiratory or Not sensitizising skin sensitization Germ cell Negative mutagenicity Carcinogenicity Negative Reproductive Rat Negative toxicity Symptoms Mucous membrane irritation Silica, amorphous Acute toxicity, by LD50 >500 Mg/kg Rat oral route 0 Acute toxicity, by LD50 >500 Mg/kg Rabbit dermal route 0 Acute toxicity, by LD50 >200 Mg/kg Rat References dermal route 0 Acute toxicity, by LD50 >200 Mg/kg Rat OECD 402 dermal route 0 (Acute Dermal Toxicity) This technical / safety data sheet replaces the previous ones. 20-36 Acute toxicity, by LC50 >0,69 Mg/l/4h Rat inhalation 1 Skin Rabbit Not irritant, references corrosion/irritatio n Skin Rabbit OECD 404 Not irritant corrosion/irritatio (Acute n dermal irritation/cor rosion) Serious eye Rabbit Not irritant. References damage/irritation Serious eye Rabbit OECD 405 Nor irritant damage / (Acute Eye irritation Irritation/Cor rosion( Germ cell OECD 471 Negative mutagenicity (Bacterial Reverse Mutation Test) Germ cell OECD 471 Negative, References mutagenicity (Bacterial Reverse Mutation Test) B. Relevant hazards for the mixture C. Symptoms/routes of exposure • Skin contact There may be mild irritation at the site of contact. • Eye contact There may be irritation and redness. • Ingestion There may be soreness and redness of the mouth and throat. Inhalation of fumes from the stomach may cause symptoms similar to direct inhalation. • Inhalation There may be irritation of the throat with a feeling of tightness in the chest. Drowsiness or mental confusion may occur. B COMPONENT 11.1 Information on toxicological effects B component Toxicity/effect Endpoint Value Unit Organis Test method Notes m Acute toxicity, by oral route ATE >2000 Mg/kg Calculat ed value Acute toxicity, by dermal ATE >2000 Mg/kg Calculat route: ed value This technical / safety data sheet replaces the previous ones. 21-36 Acute toxicity, by ATE >20 inhalation: Acute toxicity, by ATE >5 inhalation: Skin corrosion/irritation: Serious eye damage/irritation: Respiratory or skin sensitisation: Germ cell mutagenicity: Carcinogenicity: Reproductive toxicity: Specific target organ toxicity - single exposure (STOT-SE): Specific target organ toxicity - repeated exposure (STOTRE):