Merestinib

Hazard statements (CLP)

H315, H317, H318, H334, H335, H341, H361, H370, H413

Code

Statements

H315

Causes skin irritation

SECTION 2: Hazards identification

Product Name/Chemical Name CAS Number MW Chemical Formula Concentration Merestinib 1206799-15-6 498.6 C30H22F2N6O3 100% Merestinib: Emergency Overview

2.3 Other hazards

Target organ effect, Harmful by ingestion, Irritant, Carcinogen Target Organs: Heart, bone marrow, blood, liver

2.1 Classification of the substance or mixture

Skin irritation (Category 2), H315 Serious eye damage (Category 1), H318 Respiratory sensitisation (Category 1), H334 Skin sensitisation (Category 1), H317 Germ cell mutagenicity (Category 2), H341 Reproductive toxicity (Category 2), H361 Specific target organ toxicity - single exposure (Category 1), H370 Specific target organ toxicity - single exposure (Category 3), Respiratory system, H335 Chronic aquatic toxicity (Category 4), H413

Signal word

Danger

Hazard statements

H315: Causes skin irritation. H317: May cause an allergic skin reaction. H318: Causes serious eye damage. H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled. H335: May cause respiratory irritation. H341: Suspected of causing genetic defects. H361: Suspected of damaging fertility or the unborn child. H370: Causes damage to organs. H413: May cause long lasting harmful effects to aquatic life.

Precautionary statements

P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P260: Do not breathe {dust/fume/gas/mist/vapors/spray}. P264: Wash {hands} thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P271: Use only outdoors or in a well-ventilated area. P272: Contaminated work clothing should not be allowed out of the workplace. P273: Avoid release to the environment. P280: Wear {protective gloves/protective clothing/eye protection/face protection}. P302 + P352 IF ON SKIN Wash with plenty of soap and water P304 + P340 IF INHALED Remove victim to fresh air and keep at rest in a position comfortable for breathing P305 + P351 + P338 IF IN EYES Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do Continue rinsing. P310: Immediately call a POISON CENTER/doctor. P321: Specific treatment (see supplemental first aid instructions on this label). P333 + P313 If skin irritation or rash occurs Get medical advice/ attention P362: Take off contaminated clothing and wash before reuse. P403 + P233: Store in a well-ventilated place. Keep container tightly closed. P405: Store locked up. P501: Dispose of contents/ container to an approved waste disposal plant.

Health hazards

2 Flammability: 0 2 Fire: 0 Reactivity Hazard: 0

Physical hazards

0

Potential health effects

Inhalation: May be harmful if inhaled. May cause respiratory tract irritation. Skin: Harmful if absorbed through skin. Causes skin irritation. Eyes: Causes eye irritation. Ingestion: Harmful if swallowed.